Results 51 to 60 of about 560,842 (308)

Changes in Imja Tsho in the Mount Everest Region of Nepal [PDF]

, 2014
Imja Tsho, located in the Sagarmatha ( Everest) National Park of Nepal, is one of the most studied and rapidly growing lakes in the Himalayan range. Compared with previous studies, the results of our sonar bathymetric survey conducted in September of ...
Byers, A. C., McKinney, D. C., Rounce, D. R., Somos-Valenzuela, M. A.   +3 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Glaciological results of the 2005 expedition to Inylchek Glacier, Central Tian Shan [PDF]

, 2008
Like many other glaciers in Central Asia, Southern Inylchek glacier in the Kyrgyz Tian Shan is covered by supraglacial moraine, which drastically influences melt rates and complicates the estimation of ablation. The quantification of sub-debris melt from
Hagg, Wilfried, Helm, Achim, Lambrecht, Astrid, Mayer, Christoph, Michailjlow, W.   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Ice Thickness Assessment of Non-Freshwater Lakes in the Qinghai–Tibetan Plateau Based on Unmanned Aerial Vehicle-Borne Ice-Penetrating Radar: A Case Study of Qinghai Lake and Gahai Lake

Remote Sensing
Ice thickness has a significant effect on the physical and biogeochemical processes of a lake, and it is an integral focus of research in the field of ice engineering.
Huian Jin, Xiaojun Yao, Qixin Wei, Sugang Zhou, Yuan Zhang, Jie Chen, Zhipeng Yu   +6 more
doaj   +1 more source

Analysis of the Variability and Influencing Factors of Ice Thickness during the Ablation Period in Qinghai Lake Using the GPR Ice Monitoring System

Remote Sensing, 2022
As a reliable indicator of regional climate change, the growth and decline of lake ice thickness affect the regional intra–annual heat and energy balance. In this study, a ground-penetrating radar (GPR) ice monitoring system, located approximately 1.7 km
Qixin Wei, Xiaojun Yao, Hongfang Zhang, Hongyu Duan, Huian Jin, Jie Chen, Juan Cao   +6 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Subglacial lake drainage detected beneath the Greenland ice sheet [PDF]

, 2015
The contribution of the Greenland ice sheet to sea-level rise has accelerated in recent decades. Subglacial lake drainage events can induce an ice sheet dynamic response—a process that has been observed in Antarctica, but not yet in Greenland, where the ...
A Shepherd, A Shepherd, A Sole, AJ Tedstone, AV Sundal, BE Smith, BR Parizek, C Schoof, DJ Wingham, E Hanna, E Rignot, F Walter, HJ Zwally, I Joughin, I Sasgen, ID Bartholomew, IM Howat, IM Howat, JF Nye, K Steffen, LA Stearns, LC Smith, M McMillan, M Morlighem, M Siegfried, M Tedesco, MJ Hoffman, MR van den Broeke, OV Sergienko, RL Shreve, RM Goldstein, RSW van de Wal, S Palmer, SB Das, SH Mernild, SJ Palmer, T Flament, TL Mote, V Chu, W Abdalati   +39 more
core   +1 more source