Results 31 to 40 of about 931,999 (314)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A stable liquid crystal for electro-optical displays [PDF]

, 1972
Method is reported for substitution of hydroxy (OH) group ortho to anil linkage to stabilize anil-type liquid crystal for use in electro-optical ...
Lakes, M. M.
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Anti-fungal bioactive terpenoids in the bioenergy crop switchgrass (Panicum virgatum) may contribute to ecotype-specific microbiome composition

Communications Biology, 2023
Plant derived bioactive small molecules have attracted attention of scientists across fundamental and applied scientific disciplines. We seek to understand the influence of these phytochemicals on rhizosphere and root-associated fungi.
Xingxing Li, Ming-Yi Chou, Gregory M. Bonito, Robert L. Last   +3 more
doaj   +1 more source

The influence of void size on the micropolar constitutive properties of model heterogeneous materials [PDF]

, 2013
In this paper the mechanical behaviour of model heterogeneous materials consisting of regular periodic arrays of circular voids within a polymeric matrix is investigated.
A. Waseem, A.J. Beveridge, Anderson, Beveridge, Bigoni, Bui, D.H. Nash, Dos Reis, Eringen, Eringen, Gauthier, Gauthier, Gibson, Huang, Husain, Lakes, Lakes, Lakes, M.A. Wheel, Nakamura, Nowacki, Ostoja-Starzewski, Partheepan, Sadd, Sturmath, Wheel, Yang   +26 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Thornthwaite moisture index and depth of suction change under current and future climate ‒ An Australian study

Journal of Rock Mechanics and Geotechnical Engineering
Climate change is one of the major global challenges and it can have a significant influence on the behaviour and resilience of geotechnical structures.
Md Rajibul Karim, Bikash Devkota, Md Mizanur Rahman, Hoang Bao Khoi Nguyen   +3 more
doaj   +1 more source

Integrated experimental and technoeconomic evaluation of two-stage Cu-catalyzed alkaline–oxidative pretreatment of hybrid poplar

Biotechnology for Biofuels, 2018
Background When applied to recalcitrant lignocellulosic feedstocks, multi-stage pretreatments can provide more processing flexibility to optimize or balance process outcomes such as increasing delignification, preserving hemicellulose, and maximizing ...
Aditya Bhalla, Peyman Fasahati, Chrislyn A. Particka, Aline E. Assad, Ryan J. Stoklosa, Namita Bansal, Rachel Semaan, Christopher M. Saffron, David B. Hodge, Eric L. Hegg   +9 more
doaj   +1 more source

Potential Economic, Social and Environmental Contribution Study of Urban Agriculture Based on Five Key Features Identified through Past Studies

Land, 2023
Urban agriculture (UA), for recreational (gardening) and or commercial (farming) purposes, is commonly practised around the world, and uptake is increasing globally.
Arun Kafle, James Hopeward, Baden Myers
doaj   +1 more source

Chiral effect in plane isotropic micropolar elasticity and its application to chiral lattices

, 2012
In continuum mechanics, the non-centrosymmetric micropolar theory is usually used to capture the chirality inherent in materials. However when reduced to a two dimensional (2D) isotropic problem, the resulting model becomes non-chiral.
Alderson, Auffray, Bazant, Borisenko, Brillouin, Chandraseker, Chandraseker, Chen, Cosserat, Cowin, Dirrenberger, Eringen, Eringen, G.K. Hu, G.L. Huang, Ieşan, Joumaa, Kelvin, Khurana, Kumar, Lakes, Lakes, Lakes, Lakes, Lakhtakia, Liu, Liu, Liu, Natroshvili, Natroshvili, Nowacki, Prall, Ro, Spadoni, Spadoni, Wang, X.N. Liu, Yang   +37 more
core   +1 more source