Results 41 to 50 of about 1,436,998 (354)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Recent occurrence of Cylindrospermopsis raciborskii, in Waikato lakes of New Zealand. [PDF]

, 2003
Cylindrospermopsis raciborskii is a toxin-producing species of cyanobacteria that in autumn 2003 was recorded for the first time in three shallow (max. depth ≤5 m) Waikato lakes and a hydro-electric dam on the Waikato River, New Zealand.
Antenucci J. P., Baker P. D., Barnes G. E., Cromarty P., Irwin J., Oliver R. L., Padisák J., Reynolds C. S., Utermöhl H.   +8 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Greenhouse gas emissions from lakes and impoundments: Upscaling in the face of global change

Limnology and Oceanography Letters, 2018
Lakes and impoundments are important sources of greenhouse gases (GHG: i.e., CO2, CH4, N2O), yet global emission estimates are based on regionally biased averages and elementary upscaling. We assembled the largest global dataset to date on emission rates
Tonya DelSontro, J. Beaulieu, J. Downing
semanticscholar   +1 more source

Ecosystem services of Earth’s largest freshwater lakes

, 2020
Fresh water is distributed unevenly across the globe. Earth’s 21 largest lakes hold ~2/3 of all global, liquid, surface, fresh water and occupy diverse ecological and social settings.
R. Sterner, B. Keeler, S. Polasky, R. Poudel, Kirsten S. Rhude, Maggie Rogers   +5 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Thornthwaite moisture index and depth of suction change under current and future climate ‒ An Australian study

Journal of Rock Mechanics and Geotechnical Engineering
Climate change is one of the major global challenges and it can have a significant influence on the behaviour and resilience of geotechnical structures.
Md Rajibul Karim, Bikash Devkota, Md Mizanur Rahman, Hoang Bao Khoi Nguyen   +3 more
doaj   +1 more source

Integrated experimental and technoeconomic evaluation of two-stage Cu-catalyzed alkaline–oxidative pretreatment of hybrid poplar

Biotechnology for Biofuels, 2018
Background When applied to recalcitrant lignocellulosic feedstocks, multi-stage pretreatments can provide more processing flexibility to optimize or balance process outcomes such as increasing delignification, preserving hemicellulose, and maximizing ...
Aditya Bhalla, Peyman Fasahati, Chrislyn A. Particka, Aline E. Assad, Ryan J. Stoklosa, Namita Bansal, Rachel Semaan, Christopher M. Saffron, David B. Hodge, Eric L. Hegg   +9 more
doaj   +1 more source

Potential Economic, Social and Environmental Contribution Study of Urban Agriculture Based on Five Key Features Identified through Past Studies

Land, 2023
Urban agriculture (UA), for recreational (gardening) and or commercial (farming) purposes, is commonly practised around the world, and uptake is increasing globally.
Arun Kafle, James Hopeward, Baden Myers
doaj   +1 more source

New Records for \u3ci\u3eEuhrychiopsis Lecontei\u3c/i\u3e (Coleoptera: Curculionidae) and Their Densities in Wisconsin Lakes [PDF]

, 2018
The native aquatic weevil, Euhrychiopsis lecontei is currently being researched as a potential biological control for the exotic aquatic macrophyte Eurasian watermilfoil (Myriophyllum spicatum), yet little is known about its specific distribution in ...
Bozek, Michael A, Helsel, Daniel R, Jester, Laura L, Sheldon, Sallie P   +3 more
core   +2 more sources