Results 51 to 60 of about 1,436,998 (354)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Developmental constraint of insect audition
Frontiers in Zoology, 2006 Background Insect ears contain very different numbers of sensory cells, from only one sensory cell in some moths to thousands of sensory cells, e.g. in cicadas.
Strauß Johannes, Lakes-Harlan Reinhard
doaj +1 more source
Communications Biology, 2023 Plant derived bioactive small molecules have attracted attention of scientists across fundamental and applied scientific disciplines. We seek to understand the influence of these phytochemicals on rhizosphere and root-associated fungi.
Xingxing Li +3 more
doaj +1 more source
, 1992 Lakes have always held an aesthetic fascination for people; they figure prominently in both art and literature and have even been endowed with spiritual qualities. For example, the nineteenth century American writer Henry D.
Green, John D., Lowe, David J.
core +1 more source
An estimate of the chemical composition of Titan's lakes
, 2009 Hundreds of radar-dark patches interpreted as lakes have been discovered in the north and south polar regions of Titan. We have estimated the composition of these lakes by using the direct abundance measurements from the Gas Chromatograph Mass ...
Cordier, D. +4 more
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
HCA Healthcare Journal of Medicine, 2022 Description Shuffling along on an early fall morning in Germany, I looked out onto this lake and felt a sense of peace. The rolling fog weaved through the trees, caressing the floating vessels and kissing the calm water. The sight eased my soul in those early hours.
openaire +2 more sources
On Track? Ensuring the Resilience of the Great Lakes Compact [PDF]
, 2013 The Great Lakes hold about 20 percent of the world's available surface freshwater, and 84 percent of North America's surface freshwater. As a resource, the lakes and their tributaries are invaluable -- providing drinking water for 40 million people and ...
core
Energy input is primary controller of methane bubbling in subarctic lakes [PDF]
, 2014 Emission of methane (CH4) from surface waters is often dominated by ebullition (bubbling), a transport mode with high‐spatiotemporal variability. Based on new and extensive CH4 ebullition data, we demonstrate striking correlations (r2 between 0.92 and 0 ...
Anthony +35 more
core +3 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source