Results 191 to 200 of about 116,803 (294)

AlpIce‐1: a database of geochronological and geomorphological constraints on Alps‐wide palaeoglacier fluctuations between the Last Glacial Maximum and the Holocene

open access: yesBoreas, EarlyView.
The AlpIce‐1 database is the first compilation of published geomorphological and geochronological markers constraining build‐up, culmination and decay of glaciers from the Last Glacial Maximum through the Holocene across the entire European Alps. AlpIce‐1 integrates more than 4200 surface‐exposure and radiocarbon ages, homogenized, quality controlled ...
Sarah Kamleitner   +6 more
wiley   +1 more source

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

Circle of Willis-Guided Localization for Simultaneous Detection and Classification of Large Vessel Occlusions in Brain CTA. [PDF]

open access: yesNeuroinformatics
Abramova V   +8 more
europepmc   +1 more source

Research progress on intraocular lens power calculation in cataract patients with prior radial keratotomy. [PDF]

open access: yesFront Med (Lausanne)
Zhao Q   +7 more
europepmc   +1 more source

Monocytes Derived From Human Pluripotent Stem Cells Engineered for Detection of Pyrogens

open access: yesCell Proliferation, EarlyView.
In summary, we have developed a monocyte‐based reporter system using hESC‐Mono for interrogating the NF‐κB signalling axis, a central pathway governing pyrogenic responses. Our platform enables rapid and dose‐dependent detection of both endotoxins (LPS) and non‐endotoxins (LTA and Zymosan).
Jingjing Liu   +8 more
wiley   +1 more source

Lipophagy and lipid droplets in neurodegeneration. [PDF]

open access: yesTrends Pharmacol Sci
McKee NW   +5 more
europepmc   +1 more source

Associations between prior wasting malnutrition and indices of insulin secretion and sensitivity among six cohorts from Asia and Africa: The SAMPA study

open access: yesDiabetic Medicine, EarlyView.
Abstract Aims The role of prior wasting malnutrition (PM) in determining insulin sensitivity and secretion in low‐ and middle‐income countries (LMICs) remains unclear. We investigated associations of insulin indices with PM and whether these were modified by current body mass index (BMI).
Sharon E. Cox   +19 more
wiley   +1 more source

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