Results 111 to 120 of about 382,242 (307)

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Factors Affecting Tourists’ Satisfaction with the Ecotourism Destination in Can Gio Commune, Ho Chi Minh City

Tạp chí Phát triển và Hội nhập
The objective of this study is to analyze the factors influencing tourist satisfaction at ecotourism destinations in Can Gio Commune, Ho Chi Minh City. A qualitative study was conducted to refine the measurement scales.
Hoa Thu Thi Ha, Anh Tuan Tran, Vy Khanh Bui Nguyen   +2 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Unveiling the evolution of the CO excitation ladder through cross-correlation of CONCERTO-like experiments and galaxy redshift surveys

Astronomy & Astrophysics
Context. While acting as a foreground for [CII] line intensity mapping (LIM) experiments, rotational CO transitions serve as valuable indicators of the physical conditions of cold gas in the interstellar media of galaxies at lower redshifts.
Van Cuyck M., Béthermin M., Lagache G., Beelen A.   +3 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Finding environmental-friendly chemical synthesis with AI and high-throughput robotics

Journal of Science: Advanced Materials and Devices
Recent environmental challenges have resulted in tremendous interest in Green Chemistry, which includes designing chemical products and processes that reduce the use of environmentally harmful substances.
Van-Hao Vu, Khanh-Huyen Bui, Khoa D.D. Dang, Manh Duong-Tuan, Dung D. Le, Tung Nguyen-Dang   +5 more
doaj   +1 more source

Limfangioleiomiomatoza (LAM) : trudności diagnostyczne [PDF]

, 2006
Background: LAM is a rare idiopathic disorder found almost exclusively in premenopausal women. It is characterized by a proliferation of abnormal smooth muscle cell in the pulmonary interstitium, in the lymphatic system of the thorax, retroperitoneum and
Nawrot, Małgorzata, Purzycka-Jazdon, Anna, Kobierowski, Marcin, Lasek, Władysław, Przybylski, Grzegorz, Jarzemska, Agnieszka   +5 more
core  

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source