Results 161 to 170 of about 4,373 (200)

A close look at autoimmune muscle disorders: association of Lambert–Eaton myasthenic syndrome with dermatomyositis

Scandinavian Journal of Rheumatology, 2004
Dermatomyositis/ polymyositis (DM/PM) and Lambert- Eaton myasthenic syndrome (LEMS) are two autoimmune disorders that have very rarely been reported to occur together in the same patient.
Rotraut Mössner
exaly   +2 more sources

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Lambert-Eaton Myasthenic Syndrome

Revue Neurologique, 1985
The Lambert-Eaton Myasthenic Syndrome (LEMS) is characterised by proximal muscle weakness initially affecting gait, autonomic symptoms (dry mouth, constipation, erectile failure), augmentation of strength during initial voluntary activation, and depressed tendon reflexes with post-tetanic potentiation.
openaire   +4 more sources

Lambert–Eaton myasthenic syndrome in childhood

European Journal of Paediatric Neurology, 2009
Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder of the neuromuscular junction. LEMS can be associated with a variety of neoplasms. Patients present with proximal muscle weakness and fatigability, often combined with areflexia. Only 5% of reported cases are children.
A, Kostera-Pruszczyk, B, Ryniewicz, K, Rowinska-Marcinska, M, Dutkiewicz, A, Kamińska   +4 more
openaire   +2 more sources

Thymoma With Lambert-Eaton Myasthenic Syndrome

The Annals of Thoracic Surgery, 2010
We describe a rare case of thymoma with Lambert-Eaton myasthenic syndrome. A 62-year-old woman reporting weakness in her legs and arms was found to have an anterior mediastinal mass on computed tomography. Electromyography showed incremental response to repeated stimulations, and thymoma with Lambert-Eaton myasthenic syndrome was diagnosed. The patient
Mitsuaki, Morimoto, Toshihiro, Osaki, Yuko, Nagara, Mantaro, Kodate, Masakatsu, Motomura, Hiroyuki, Murai   +5 more
openaire   +2 more sources

Immunopathology of the Lambert-Eaton myasthenic syndrome

Springer Seminars in Immunopathology, 1995
LEMS is an antibody-mediated autoimmune disease that can occur in isolation, or as a paraneoplastic disorder in association with SCLC (60% of patients). The underlying defect is a reduction in the quantal release of the neurotransmitter ACh from the presynaptic nerve terminal at the neuromuscular junction.
B, Lang, J, Newsom-Davis
openaire   +2 more sources

Lambert-Eaton Myasthenic Syndrome and Botulism

Continuum, 2022
This article reviews the pathophysiology, epidemiology, clinical features, diagnosis, and treatment of Lambert-Eaton myasthenic syndrome (LEMS) and botulism, presynaptic disorders of neuromuscular transmission in which rapid diagnosis improves long-term outcomes.Therapy for LEMS has seen significant advances in recent years due to the approval of ...
openaire   +2 more sources

Lambert-Eaton Myasthenic Syndrome in Children

Journal of Child Neurology, 2002
Lambert-Eaton myasthenic syndrome is a presynaptic disorder of neuromuscular transmission. It is characterized by muscle weakness, hyporeflexia, and autonomic dysfunction. It is most often associated with small cell carcinomas of the lung. Rare cases have been reported in children.
Chang-Yong, Tsao, Jerry R, Mendell, Miriam L, Friemer, John T, Kissel   +3 more
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Treatment for Lambert-Eaton myasthenic syndrome

2003
Lambert-Eaton myasthenic syndrome is an autoimmune presynaptic disorder of neuromuscular transmission. Treatments attempt to overcome the harmful autoimmune process, or to improve residual neuromuscular transmission, in order to reverse muscle weakness.The objective was to examine the efficacy of treatment in Lambert-Eaton myasthenic syndrome.We ...
P, Maddison, J, Newsom-Davis
openaire   +3 more sources

THE LAMBERT-EATON MYASTHENIC SYNDROME

Brain, 1988
The clinical and electrophysiological features of 50 consecutive patients with the Lambert-Eaton myasthenic syndrome (LEMS) have been analysed. Carcinoma was detected (CD group) in 25, of whom 21 had small cell lung cancer (SCLC). SCLC was evident within 2 yrs of onset of LEMS symptoms in 20/21 cases, and at 3.8 yrs in 1/21.
J H, O'Neill, N M, Murray, J, Newsom-Davis   +2 more
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Lambert‐Eaton Myasthenic Syndrome

Annals of the New York Academy of Sciences, 2003
Abstract: A high index of suspicion is essential in arriving at the correct diagnosis of Lambert‐Eaton myasthenic syndrome (LEMS). LEMS should be considered in the differential in any patient who has proximal weakness, reduced or absent muscle stretch reflexes, and dry mouth.
openaire   +3 more sources