Results 1 to 10 of about 97,590 (85)
Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for Glaucoma
International Journal of Molecular Sciences, 2022 Glaucomatous optic neuropathy is the leading cause of irreversible blindness in the world. The chronic disease is characterized by optic nerve degeneration and vision field loss.
Ryan G Strickland +2 more
exaly +2 more sources
Calcium-Signalling in Human Glaucoma Lamina Cribrosa Myofibroblasts
International Journal of Molecular Sciences, 2023 Glaucoma is one of the most common causes of treatable visual impairment in the developed world, affecting approximately 64 million people worldwide, some of whom will be bilaterally blind from irreversible optic nerve damage.
Mustapha Irnaten +2 more
exaly +2 more sources
Isolation and characterization of human optic nerve head astrocytes and lamina cribrosa cells
Experimental Eye Research, 2020 The lamina cribrosa is the initial site of glaucomatous injury. Pathological changes to the lamina cribrosa include posterior displacement of the lamina cribrosa, loss of trophic support, and remodeling of the extracellular matrix. Optic nerve head (ONH)
Tara Tovar-Vidales, Abbot Clark
exaly +2 more sources
Journal of Clinical Medicine, 2023 (1) Background: To compare optic nerve sheath diameter (ONSD) in normal-tension glaucoma (NTG) and healthy eyes and to investigate the association between ONSD and lamina cribrosa (LC) morphology.
Seung Hyen Lee +3 more
semanticscholar +1 more source
bioRxiv, 2023 Astrocytes in the lamina region of the optic nerve head play vital roles in supporting retinal ganglion cell axon health. In glaucoma, these astrocytes are implicated as early responders to stressors, undergoing characteristic changes in cell function as
S. Waxman +6 more
semanticscholar +1 more source
Modeling the Biomechanics of the Lamina Cribrosa Microstructure in the Human Eye
Acta Biomaterialia, 2021 Glaucoma is among the leading causes of blindness worldwide that is characterized by irreversible damage to the retinal ganglion cell axons in the lamina cribrosa (LC) region of the optic nerve head (ONH), most often associated with elevated intraocular ...
A. Karimi +4 more
semanticscholar +1 more source
Investigative Ophthalmology and Visual Science, 2022 Purpose The laminar region of the optic nerve head (ONH), thought to be the site of damage to the retinal ganglion cell axons in glaucoma, is continuously loaded on its anterior and posterior surfaces by dynamic intraocular pressure (IOP) and orbital ...
A. Karimi +4 more
semanticscholar +1 more source
Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma
Investigative Ophthalmology and Visual Science, 2022 Purpose Extracellular matrix stiffening is characteristic of both aging and glaucoma, and acts as a promoter and perpetuator of pathological fibrotic remodeling.
R. Murphy +7 more
semanticscholar +1 more source
The Strain Response to Intraocular Pressure Decrease in the Lamina Cribrosa of Glaucoma Patients
Ophthalmology Glaucoma, 2022 Objective: To measure biomechanical strains in the lamina cribrosa (LC) of living human eyes with intraocular pressure lowering. Design: Cohort study.
Cameron A. Czerpak +4 more
semanticscholar +1 more source
Aquaporin 4 is not present in normal porcine and human lamina cribrosa
PLoS ONE, 2022 Aquaporin 4 is absent from astrocytes in the rodent optic nerve head, despite high expression in the retina and myelinated optic nerve. The purpose of this study was to quantify regional aquaporin channel expression in astrocytes of the porcine and human
Elizabeth C. Kimball +7 more
semanticscholar +1 more source