Results 21 to 30 of about 142,195 (126)

Mirna Expression in Glaucomatous and TGFβ2 Treated Lamina Cribrosa Cells

International Journal of Molecular Sciences, 2021
Glaucoma is a group of optic neuropathies that leads to irreversible vision loss. The optic nerve head (ONH) is the site of initial optic nerve damage in glaucoma.
Navita N. Lopez, R. Rangan, A. Clark, Tara Tovar-Vidales   +3 more
semanticscholar   +1 more source

Racial Differences in the Rate of Change in Anterior Lamina Cribrosa Surface Depth in the African Descent and Glaucoma Evaluation Study

Investigative Ophthalmology and Visual Science, 2021
Purpose The purpose of this study was to determine if the rate of change in the depth of the surface of the lamina cribrosa due to glaucomatous remodeling differs between glaucoma patients of African descent (AD) and European descent (ED).
C. Girkin, A. Belghith, C. Bowd, F. Medeiros, R. Weinreb, J. Liebmann, J. Proudfoot, L. Zangwill, M. Fazio   +8 more
semanticscholar   +1 more source

Correlation Between Changes in Lamina Cribrosa Structure and Visual Field in Primary Open-Angle Glaucoma

Clinical Ophthalmology, 2021
Purpose To investigate the correlation between changes in lamina cribrosa (LC) structure using enhanced depth imaging (EDI) and severity of visual field (VF) affection in primary open-angle glaucoma (POAG).
Ahmed El Basty, Raouf Gaber, Ahmed F Elmaria, Moataz Sabry, Tarek R. Hussein   +4 more
semanticscholar   +1 more source

The Role of Autotaxin in Lamina Cribrosa Cells in Glaucoma

, 2023
Glaucoma is the leading cause of irreversible blindness worldwide. Current medical and surgical therapies do not directly target the mechanisms underlying glaucoma pathogenesis. In primary open angle glaucoma, extracellular matrix remodeling and fibrosis
O'Regan, Amy
core   +1 more source

How is eyeball growth associated with optic nerve head shape and glaucoma? The Lamina cribrosa/Bruch's membrane opening offset theory.

Experimental Eye Research
The optic nerve head (ONH) is a complex structure wherein the axons of the retinal ganglion cells extrude from the eyeball through three openings: 1) the Bruch's membrane opening (BMO) in the retinal layer, 2) the anterior scleral canal opening in the ...
Seok Hwan Kim, Martha Kim, Kyoung Min Lee   +2 more
semanticscholar   +1 more source

A Noninvasive Clinical Method to Measure in Vivo Mechanical Strains of the Lamina Cribrosa by OCT

Ophthalmology Science
Objective To measure mechanical strain of the lamina cribrosa (LC) after intraocular pressure (IOP) change produced 1 week after a change in glaucoma medication. Design Cohort study.
Vanessa Hannay, Cameron A. Czerpak, H. Quigley, Thao D. Nguyen   +3 more
semanticscholar   +1 more source

Age related compliance of the lamina cribrosa in human eyes

, 2000
AIMS To investigate changes in the mechanical compliance of ex vivo human lamina cribrosa with age. METHODS A laser scanning confocal microscope was used to image the surface of the fluorescently labelled lamina cribrosa in cadaver eyes. A method was
Albon, J., Easty, D. L., Karwatowski, Wojciech S.S., Albon, Julie, Easty, David L., Karwatowski, W. S. S., Purslow, P. P., J. Albon, Purslow, Peter P.   +8 more
core   +1 more source

Underlying Microstructure of the Lamina Cribrosa at the Site of Microvasculature Dropout

Investigative Ophthalmology and Visual Science
Purpose To determine the microstructure of the lamina cribrosa (LC) associated with microvasculature dropout (MvD) of the deep optic nerve head (ONH) in primary open-angle glaucoma (POAG) and to identify factors related to the presence of MvD.
Eun Ji Lee, Dong Kyun Han, Y. Roh, Tae-Woo Kim   +3 more
semanticscholar   +1 more source

Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa

, 2018
The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina ...
Lu, Chen, Bo Wang, Grulkowski, Ireneusz, Ishikawa, Hiroshi, Fujimoto, James G, Liu, Jonathan Jaoshin, Gadi Wollstein, Chen Lu, Sigal, Ian A., Ireneusz Grulkowski, Schuman, Joel S., Jonathan Liu, Ian A. Sigal, Bilonick, Richard A., Lucy, Katie A., Larry Kagemann, Kagemann, Larry, Zachary Nadler, Wang, Bo, Nadler, Zachary, Richard A. Bilonick, Hiroshi Ishikawa, James G. Fujimoto, Joel S. Schuman, Wollstein, Gadi, Katie A. Lucy   +25 more
core   +1 more source

The Robust Lamina Cribrosa Vasculature: Perfusion and Oxygenation Under Elevated Intraocular Pressure

Investigative Ophthalmology and Visual Science
Purpose Elevated intraocular pressure (IOP) is thought to cause lamina cribrosa (LC) blood vessel distortions and potentially collapse, adversely affecting LC hemodynamics, reducing oxygenation, and triggering, or contributing to, glaucomatous neuropathy.
Yuankai Lu, Yi Hua, Bing-Rui Wang, Fuqiang Zhong, Andrew G. Theophanous, Shaharoz Tahir, Po-Yi Lee, I. Sigal   +7 more
semanticscholar   +1 more source