Results 91 to 100 of about 217,252 (285)

The Tumor Suppressor HHEX Inhibits Axon Growth when Prematurely Expressed in Developing Central Nervous System Neurons [PDF]

, 2015
Neurons in the embryonic and peripheral nervoussystem respond to injury by activating transcriptional programs supportive of axon growth, ultimately resulting in functional recovery.
Blackmore, Murray G., Callif, Ben L., Coley, Denise M., Kramer, Audra A., Lerch, Jessica K., Simpson, Matthew T., Thiel, Laura K., Venkatesh, Ishwariya, Wang, Zimei, Winsor, Kristen N.   +9 more
core   +2 more sources

The Epidermal Basement Membrane Is a Composite of Separate Laminin- or Collagen IV-containing Networks Connected by Aggregated Perlecan, but Not by Nidogens*

Journal of Biological Chemistry, 2012
Background: The supramolecular assemblies of basement membranes are incompletely understood. Results: Basement membranes are suprastructural composites of two separable, alloyed networks containing collagens IV or laminins.
Daniel Timo Behrens, Daniela Villone, M. Koch, G. Brunner, L. Sorokin, H. Robenek, L. Bruckner-Tuderman, P. Bruckner, U. Hansen   +8 more
semanticscholar   +1 more source

Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS

PLoS ONE, 2012
TH17 cells enter tissues to facilitate pathogenic autoimmune responses, including multiple sclerosis (MS). However, the adhesion molecules involved in the unique migratory capacity of TH17 cells, into both inflamed and uninflamed tissues remain unclear ...
K. Flanagan, Kent Fitzgerald, J. Baker, K. Regnstrom, S. Gardai, F. Bard, S. Mocci, Pui Seto, Monica You, C. Larochelle, A. Prat, S. Chow, Lauri Li, C. Vandevert, W. Zago, C. Lorenzana, Christopher Nishioka, Jennifer C Hoffman, R. Botelho, Christopher P. Willits, Kevin Tanaka, Jennifer Johnston, T. Yednock   +22 more
semanticscholar   +1 more source

Laminin Isoforms and Laminin-Producing Cells in Rat Anterior Pituitary

ACTA HISTOCHEMICA ET CYTOCHEMICA, 2012
Laminin is a key component of the basement membrane and is involved in the structural scaffold and in cell proliferation and differentiation. Research has identified 19 laminin isoforms, which are assemblies of α, β, and γ chains (eg, the α1, β1, and γ1 chains form the laminin 111 isoform).
Takashi Yashiro, Takehiro Tsukada, Motoshi Kikuchi, Ken Fujiwara, Dini Ramadhani, Kotaro Horiguchi   +5 more
openaire   +4 more sources

Purification and characterization of mammalian integrins expressed by a rat neuronal cell line (PC12): evidence that they function as alpha/beta heterodimeric receptors for laminin and type IV collagen. [PDF]

, 1988
Cells of the rat neuronal line, PC12, adhere well to substrates coated with laminin and type IV collagen, but attach poorly to fibronectin. Adhesion and neurite extension in response to these extracellular matrix proteins are inhibited by Fab fragments ...
Damsky, CH, Reichardt, LF, Tomaselli, KJ
core   +1 more source

The Laminin α Chains: Expression, Developmental Transitions, and Chromosomal Locations of α1-5, Identification of Heterotrimeric Laminins 8–11, and Cloning of a Novel α3 Isoform

Journal of Cell Biology, 1997
Laminin trimers composed of α, β, and γ chains are major components of basal laminae (BLs) throughout the body. To date, three α chains (α1–3) have been shown to assemble into at least seven heterotrimers (called laminins 1–7).
J. Miner, B. Patton, S. Lentz, D. Gilbert, W. Snider, N. Jenkins, N. Copeland, J. Sanes   +7 more
semanticscholar   +1 more source

Dysfunction of 67-kDa Laminin Receptor Disrupts BBB Integrity via Impaired Dystrophin/AQP4 Complex and p38 MAPK/VEGF Activation Following Status Epilepticus

Frontiers in Cellular Neuroscience, 2019
Status epilepticus (SE, a prolonged seizure activity) impairs brain-blood barrier (BBB) integrity, which results in secondary complications following SE.
Hana Park, Hana Park, Seo-Hyeon Choi, Seo-Hyeon Choi, Min-Jeong Kong, Min-Jeong Kong, Tae-Cheon Kang, Tae-Cheon Kang   +7 more
doaj   +1 more source

Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation. [PDF]

, 2019
Congenital pulmonary airway malformation (CPAM) is the most common congenital lesion detected in the neonatal lung, which may lead to respiratory distress, infection, and pneumothorax.
Jiang, Yi, Lou, Jianlin, Luo, Yongfeng, Moats, Rex, Pryhuber, Gloria S, Shi, Wei, Tang, Yang, Wang, Larry L, Warburton, David, Zhou, Shengmei   +9 more
core   +3 more sources

Interactions of laminin with the amyloid ß peptide: Implications for Alzheimer's disease

Brazilian Journal of Medical and Biological Research, 2001
Extensive neuronal cell loss is observed in Alzheimer's disease. Laminin immunoreactivity colocalizes with senile plaques, the characteristic extracellular histopathological lesions of Alzheimer brain, which consist of the amyloid ß (Aß) peptide ...
Morgan C., Inestrosa N.C.
doaj  

Gpr126/Adgrg6 has Schwann cell autonomous and nonautonomous functions in peripheral nerve injury and repair [PDF]

, 2016
Schwann cells (SCs) are essential for proper peripheral nerve development and repair, although the mechanisms regulating these processes are incompletely understood.
Carlin, Dan, Cavalli, Valeria, Harty, Breanne L, Joseph, Jessica, Mogha, Amit, Monk, Kelly R, Piao, Xianhua, Sanchez, Nicholas E, Suter, Ueli   +8 more
core   +2 more sources