Results 161 to 170 of about 178,658 (287)

Type 1 diabetes remodels the area postrema perivascular-immune interface. [PDF]

J Cereb Blood Flow Metab
Furube E, Tanaka Y, Yoshida S, Ohgidani M.   +3 more
europepmc   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Correction: Laminin N-terminus α31 regulates corneal epithelial cell adhesion and migration through modifying the organization and proteolytic processing of laminin 332. [PDF]

PLoS One
Troughton LD, Iorio V, Shaw L, Sugden CJ, Chavda ND, Wilson P, Simoens D, Conway AE, Sala S, Kaja S, Yamamoto K, Hamill KJ.   +11 more
europepmc   +1 more source

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao, Chuyu Yun, Hongying Shan, Yuqian Wang, Xiunan Chen, Weisi Lian, Tianliu Peng, Min Zhao, Xunsi Qin, Kailun Hu, Ping Zhou, Yue Wang, Yanli Pang, Rong Li   +13 more
wiley   +1 more source

Vascular basement membrane laminins modulate functional zonation of cerebral microvessels. [PDF]

J Cereb Blood Flow Metab
Deshpande T, Kapupara K, Hannocks MJ, Huppert J, Samawar SK, Thulichery DR, Budny S, Ghavampour S, Song J, Meng L, Adams RH, Jeong HW, Wachsmuth L, Faber C, Soltwisch J, Hallmann R, Sorokin L.   +16 more
europepmc   +1 more source

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, EarlyView.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

Integrins α3 and α6 promote Th17 cell migration by activating the purinergic receptor P2X4. [PDF]

Purinergic Signal
Hamoudi C, Lashgari A, Aoudjit F.
europepmc   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Age-mimicking hydrogel stiffness recapitulates the mechanical niche of the hippocampus to regulate neural stem cell senescence. [PDF]

Mater Today Bio
Guo L, Ge L, Li Y, Wang S, Li H, Wang X, Qian W, Zhang Y, Guo L, Guo L, Cheng R, Ji W, Fu W, Zhang L, Zhang R.   +14 more
europepmc   +1 more source

The role of 67 kDa laminin receptor in G-CSF-induced hematopoietic stem cell mobilization [PDF]

, 2007
Visconte, Valeria
core   +1 more source