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Analysis of the assembly of laminin and the laminin-entactin complex with laminin chain specific monoclonal and polyclonal antibodies [PDF]
Biochemistry, 1988 Antibodies specific for the A, B1, and B2 chains of laminin have been obtained and characterized. Lam V, a rat X mouse monoclonal antibody, was obtained by immunizing Lewis rats with the extracellular matrix derived from the mouse endodermal line M1536-B3.
Chuanyue Wu +2 more
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Pharmacology & Therapeutics, 1992
This short and selective review of the role of laminin in neural development discusses emerging concepts about the way that elements of the extracellular matrix control the differentiation of embryonic neurons. New laminin isoforms have recently been discovered, discoveries which now reveal the very great heterology of basement membranes in different ...
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This short and selective review of the role of laminin in neural development discusses emerging concepts about the way that elements of the extracellular matrix control the differentiation of embryonic neurons. New laminin isoforms have recently been discovered, discoveries which now reveal the very great heterology of basement membranes in different ...
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Microscopy Research and Technique, 2000
The laminin protein family has diverse tissue expression patterns and is involved in the pathology of a number of organs, including skin, muscle, and nerve. In the skin, laminins 5 and 6 contribute to dermal-epidermal cohesion, and mutations in the constituent chains result in the blistering phenotype observed in patients with junctional epidermolysis ...
Kelly A. McGowan +2 more
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The laminin protein family has diverse tissue expression patterns and is involved in the pathology of a number of organs, including skin, muscle, and nerve. In the skin, laminins 5 and 6 contribute to dermal-epidermal cohesion, and mutations in the constituent chains result in the blistering phenotype observed in patients with junctional epidermolysis ...
Kelly A. McGowan +2 more
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Clinical Immunology, 2016
Laminins are ubiquitous constituents of the basement membranes with major architectural and functional role as supported by the fact that absence or mutations of laminins lead to either lethal or severely impairing phenotypes. Besides genetic defects, laminins are involved in a wide range of human diseases including cancer, infections, and inflammatory
Florina Florea +3 more
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Laminins are ubiquitous constituents of the basement membranes with major architectural and functional role as supported by the fact that absence or mutations of laminins lead to either lethal or severely impairing phenotypes. Besides genetic defects, laminins are involved in a wide range of human diseases including cancer, infections, and inflammatory
Florina Florea +3 more
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Neuronal laminin receptors [PDF]
Trends in Neurosciences, 1989 The ability of the extracellular matrix protein laminin to regulate the survival and differentiation of neurons has led to the search for a neuronal laminin receptor. This article reviews the evidence for the existence of laminin receptors, and then goes on to discuss the difficulties in making the jump from a pharmacological demonstration of the ...
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Journal of Cellular Biochemistry, 2006
AbstractThe basement membrane (BM) protein laminin‐332 (Lm332) (laminin‐5) has unique activity and structure as compared with other laminins: it strongly promotes cellular adhesion and migration, and its α3, β3, and γ2 chains are all truncated in their N‐terminal regions (short arms). In the present study, we investigated the biological function of the
Kaoru Miyazaki +3 more
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AbstractThe basement membrane (BM) protein laminin‐332 (Lm332) (laminin‐5) has unique activity and structure as compared with other laminins: it strongly promotes cellular adhesion and migration, and its α3, β3, and γ2 chains are all truncated in their N‐terminal regions (short arms). In the present study, we investigated the biological function of the
Kaoru Miyazaki +3 more
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Hepatology Research, 1999
Abstract Recently several laminin isoforms were newly identified and found to distribute in a tissue and cell type-specific manner. We have studied the expression of several laminin isoforms, including α 1(A), α 2(M), β 1(B1), β 2(S), and γ 1(B2) subunits, in normal and CCl 4 -induced fibrotic rat liver by RT-PCR and performed ...
Takahiro Sakai +5 more
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Abstract Recently several laminin isoforms were newly identified and found to distribute in a tissue and cell type-specific manner. We have studied the expression of several laminin isoforms, including α 1(A), α 2(M), β 1(B1), β 2(S), and γ 1(B2) subunits, in normal and CCl 4 -induced fibrotic rat liver by RT-PCR and performed ...
Takahiro Sakai +5 more
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Nonenzymatic Glycosylation of Laminin and the Laminin Peptide CIKVAVS Inhibits Neurite Outgrowth
Diabetes, 1993Nerve regeneration in diabetic animals is delayed and qualitatively impaired, but the mechanisms responsible for these defects have not been elucidated. The extracellular matrix protein laminin promotes the extension of neuronal processes, and recent studies have localized neurite-promoting activity to a lysine-containing sequence (IKVAV) within the ...
Michael Brownlee +2 more
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Laminins of the neuromuscular system
Microscopy Research and Technique, 2000The mammalian neuromuscular system expresses seven laminin genes (alpha 1, alpha 2, alpha 4, alpha 5, beta 1, beta 2, and gamma 1), produces seven isoforms of the laminin trimer (laminins 1, 2, 4, 8, 9, 10, and 11), and distributes these trimers to at least seven distinct basal laminae (perineurial, endoneurial, terminal Schwann cell, myotendinous ...
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Laminin--a glycoprotein from basement membranes.
Journal of Biological Chemistry, 1979R. Timpl +5 more
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