Results 51 to 60 of about 217,252 (285)

Laminin 511-E8, an autoantigen in IgG4-related cholangitis, contributes to cholangiocyte protection

JHEP Reports
Background & Aims: IgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease. Anti-laminin 511-E8 autoantibodies have been identified in its pancreatic manifestation.
David C. Trampert, Remco Kersten, Dagmar Tolenaars, Aldo Jongejan, Stan F.J. van de Graaf, Ulrich Beuers   +5 more
doaj   +1 more source

Nerve Fiber Immunohistochemical Panel Discriminates between Nerve Sheath and Perivascular Wall Tumors

Veterinary Sciences, 2022
Benign and malignant nerve sheath tumors (NST) pose a major challenge in routine diagnostic anatomic pathology because of shared histomorphological features with other soft-tissue tumors (STT).
Sílvia Sisó, Paola Marco-Salazar, Paola Roccabianca, Giancarlo Avallone, Robert J. Higgins, Verena K. Affolter   +5 more
doaj   +1 more source

Vascular Endothelial Growth Factor (VEGF) Prevents the Downregulation of the Cholinergic Phenotype in Axotomized Motoneurons of the Adult Rat [PDF]

, 2018
Vascular endothelial growth factor (VEGF) was initially characterized by its activity on the vascular system. However, there is growing evidence indicating that VEGF also acts as a neuroprotective factor, and that its administration to neurons suffering ...
Acosta, Lourdes, Morcuende Fernández, Sara R., Pastor Loro, Ángel Manuel, Rodríguez de la Cruz, Rosa María, Silva Hucha, Silvia   +4 more
core   +1 more source

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures

Journal of Cell Biology, 1988
We have defined a signal responsible for the morphological differentiation of human umbilical vein and human dermal microvascular endothelial cells in vitro.
Yasuo Kubota, H. Kleinman, G. Martin, T. Lawley   +3 more
semanticscholar   +1 more source

Laminins in Cellular Differentiation [PDF]

Trends in Cell Biology, 2019
Basement membrane laminins (LNs) have been shown to modulate cellular phenotypes and differentiation both in vitro and during organogenesis in vivo. At least 16 laminin isoforms are present in mammals, and most are available as recombinant proteins. Ubiquitous LN511 and LN521 promote the clonal derivation and expansion of pluripotent embryonic stem ...
Monica Suryana Tjin, Karl Tryggvason, Lynn Yap, Hwee Goon Tay, Mien T. X. Nguyen   +4 more
openaire   +3 more sources

Extracellular Superoxide Dismutase, the Endothelial Basement Membrane, and the WNT Pathway: New Players in Vascular Normalization and Tumor Infiltration by T-Cells

Frontiers in Immunology, 2020
Tumor-infiltrating lymphocytes (TILs) are major players in the immune-mediated control of cancer and the response to immunotherapy. In primary cancers, however, TILs are commonly absent, suggesting T-cell entry into the tumor microenvironment (TME) to be
Diego Martínez-Rey, Lorena Carmona-Rodríguez, María Jesús Fernández-Aceñero, Emilia Mira, Santos Mañes   +4 more
doaj   +1 more source

Molecular mechanisms separating two axonal pathways during embryonic development of the avian optic tectum [PDF]

, 1991
During embryonic development of the avian optic tectum, retinal and tectobulbar axons form an orthogonal array of nerve processes. Growing axons of both tracts are transiently very closely apposed to each other. Despite this spatial proximity, axons from
Adler, Alvarado-Mallart, Bixby, Bixby, Bonhoeffer, Bonhoeffer, Boxberg, Bray, Cohen, Edelman, Elsdale, Goldberg, Goldberg, Halfter, Halfter, Halfter, Halfter, Halfter, Halfter, Halfter, Hamburger, Hankin, Harris, Haydon, Kapfhammer, Kapfhammer, Kapfhammer, Katz, Kroger, Kröger, Lagenaur, LaVail, Letourneau, Letourneau, Liesi, Linser, Mattson, McCobb, McLoon, O'Leary, Puelles, Rager, Raper, Rathjen, Rogers, Rosner, Sanes, Silver, Silver, Smalheiser, Thanos, Tomaselli, Vanselow, Walter, Wictorin, Zipser   +55 more
core   +1 more source

Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-alpha2-deficient congenital muscular dystrophy (MDC1A) [PDF]

, 2012
BACKGROUND: Laminin-alpha2-deficient congenital muscular dystrophy (MDC1A) is a severe muscle-wasting disease for which no curative treatment is available.
Lin, Shuo, Meinen, Sarina, Ruegg, Markus A.   +2 more
core   +1 more source

The Extracellular Matrix Protein Laminin α2 Regulates the Maturation and Function of the Blood–Brain Barrier

Journal of Neuroscience, 2014
Laminins are major constituents of the gliovascular basal lamina of the blood–brain barrier (BBB); however, the role of laminins in BBB development remains unclear.
Michael J Menezes, Freyja K McClenahan, Cindy V. Leiton, Azeez Aranmolate, Xiwei Shan, H. Colognato   +5 more
semanticscholar   +1 more source

Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration

Cell Reports, 2017
Endothelial basement membranes constitute barriers to extravasating leukocytes during inflammation, a process where laminin isoforms define sites of leukocyte exit; however, how this occurs is poorly understood.
Jian Song, Xueli Zhang, Konrad Buscher, Ying Wang, Huiyu Wang, Jacopo Di Russo, Lixia Li, Stefan Lütke-Enking, Alexander Zarbock, Anika Stadtmann, Paul Striewski, Benedikt Wirth, Ivan Kuzmanov, Heinz Wiendl, Dörte Schulte, Dietmar Vestweber, Lydia Sorokin   +16 more
doaj   +1 more source