Results 41 to 50 of about 5,872 (213)

Protective effects of adiponectin receptor agonists against equine lamellar endoplasmic reticulum stress

Equine Veterinary Journal, EarlyView.
Abstract Background Lamellar endoplasmic reticulum (ER) stress occurs in hyperinsulinemia‐associated and sepsis‐related laminitis. Adiponectin is associated with reduced laminitis risk and inhibits ER stress in other species. Objectives To induce ER stress in ex vivo equine lamellar cells using pharmacological agents.
Marine A. Barnabé, Jonathan Elliott, Nicola J. Menzies‐Gow, Simon R. Bailey, Nicholas J. Bamford, Yu‐Mei Chang, Matthew C. Gage   +6 more
wiley   +1 more source

Plasma Amino Acid Concentration in Obese Horses with/without Insulin Dysregulation and Laminitis

Animals, 2022
Laminitic horses commonly suffer from an endocrine disease such as equine metabolic syndrome. Hyperinsulinemia is considered a key factor in the pathogenesis of laminitis.
Sabita Diana Stoeckle, Detlef Timmermann, Roswitha Merle, Heidrun Gehlen   +3 more
doaj   +1 more source

Development of a prognostic scoring system for systemic inflammatory response syndrome in donkeys

Equine Veterinary Journal, EarlyView.
Abstract Background Systemic inflammatory response syndrome (SIRS) is associated with increased mortality in horses with gastrointestinal (GI) disease. However, there are no data relating to naturally occurring SIRS in donkeys. Objectives To determine SIRS frequency in donkeys with GI disease. To develop a donkey‐specific prognostic SIRS score.
Marine A. Barnabé, Nicholas J. Bamford, Jonathan Elliott, Yu‐Mei Chang, Karen Rickards, Nicola J. Menzies‐Gow   +5 more
wiley   +1 more source

Methylated tirilazad may mitigate oligofructose-induced laminitis in horses

Frontiers in Microbiology
Laminitis is a serious health condition that can cause severe pain and lameness in horses. Due to lack of understanding of laminitis, treatments often fail to achieve the desired results.
Maimaiti Tuniyazi, Ruibo Tang, Xiaoyu Hu, Naisheng Zhang   +3 more
doaj   +1 more source

Pyrosequencing of 16S rRNA genes in fecal samples reveals high diversity of hindgut microflora in horses and potential links to chronic laminitis

BMC Veterinary Research, 2012
Background The nutrition and health of horses is closely tied to their gastrointestinal microflora. Gut bacteria break down plant structural carbohydrates and produce volatile fatty acids, which are a major source of energy for horses.
Steelman Samantha M, Chowdhary Bhanu P, Dowd Scot, Suchodolski Jan, Janečka Jan E   +4 more
doaj   +1 more source

Effect of digital hypothermia on lamellar inflammatory signaling in the euglycemic hyperinsulinemic clamp laminitis model

Journal of Veterinary Internal Medicine, 2020
Background Continuous digital hypothermia (CDH) prevents lamellar failure in the euglycemic hyperinsulinemic clamp (EHC) model of laminitis, but the protective mechanisms are unclear.
Simon M. Stokes, Teresa A. Burns, Mauria R. Watts, François‐René Bertin, Darko Stefanovski, Carlos E. Medina‐Torres, James K. Belknap, Andrew W. vanEps   +7 more
doaj   +1 more source

Analgesic use, safety and pharmacokinetics of acetaminophen in equids: A structured scoping review

Equine Veterinary Journal, EarlyView.
Abstract Background Despite its frequent use in equine clinical practice, scientific data on the use of acetaminophen in horses remain limited. Objective To map and critically appraise the available evidence on the analgesic use, safety and pharmacokinetics of acetaminophen in horses. Study Design Structured scoping review.
Francisco Medina‐Bautista, Juan Manuel Serrano‐Rodríguez, María del Mar Granados   +2 more
wiley   +1 more source

Histopathology of insulin-induced laminitis in ponies

, 2010
<p> <b>Reasons for performing study:</b> Ponies with laminitis associated with insulin resistance and hyperinsulinaemia lack systemic and/or intestinal inflammatory signs, suggesting a different pathogenesis potentially reflected ...
Sillence, M. N., C. C. POLLITT, J. C. PATTERSON-KANE, McGowan, Catherine, Patterson-Kane, Janet, McGowan, C. M., Pollitt, C. C., Asplin, K. E., K. E. ASPLIN, M. N. SILLENCE, Pollitt, Christopher, Asplin, Katie, Patterson-Kane, J. C., Patterson-Kane, J.C., C. M. Mc GOWAN, Sillence, Martin   +15 more
core   +1 more source

CLINICAL, HEMATOLOGICAL WITH SOME BIOCHEMICAL STUDY OF ACUTE LAMINITIS IN DROUGHT HORSES IN BASRAH [PDF]

Basrah Journal of Veterinary Research, 2012
Clinical sings ,hematology and some biochemical changes have been investigated in local breed drought horse affected with acute laminitis in Basrah-Iraq .The study were conducted on 55 local breed drought horse 2-10 years old and from both sexes, from ...
Hussein A. N. Al-Derawie
doaj   +1 more source

Pancreatic α‐cell dysfunction associated with equine insulin dysregulation

Equine Veterinary Journal, EarlyView.
Abstract Background Insulin dysregulation (ID) in horses is characterised by insulin resistance and exaggerated insulin responses, yet the underlying endocrine mechanisms remain incompletely understood. In humans, α‐cell dysfunction characterised by exaggerated glucagon secretion contributes to metabolic disease; however, the role of pancreatic α‐cell ...
Sanna Lindåse, Emma Strage, Josefin Söder, Johan Bröjer   +3 more
wiley   +1 more source