Results 31 to 40 of about 2,390 (199)

Integrated high-content quantification of intracellular ROS levels and mitochondrial morphofunction [PDF]

, 2016
Oxidative stress arises from an imbalance between the production of reactive oxygen species (ROS) and their removal by cellular antioxidant systems.
A Boveris, A Boveris, A Gomes, A Muchir, A Pastore, A Stangherlin, AB Salmon, AJ Meyer, AR Cardoso, AS Rambold, B Babior, B Chazotte, B Groitl, B Zhao, BC Dickinson, BC Dickinson, BC Dickinson, BC Dickinson, C Nathan, C Szabó, C Thomas, C-C Chiu, CA Glasbey, CC Winterbourn, CL Grek, CM Cremers, CT Dooley, D Giustarini, D Han, D Harman, D Poburko, D Staljanssens, DG Nicholls, DS Bilan, EF Iannetti, ET Chouchani, EW Miller, F Auchère, G Loschen, G Rabut, GC Brown, GPC Drummen, GS Baird, GT Hanson, H Dong, H Zhao, HH Rasmussen, J Estaquier, J Zielonka, JD Lambeth, JF Turrens, JF Woolley, JJ Hu, JR Casey, JS Moylan, K Bedard, K Trudeau, KA Lukyanov, KM Robinson, KM Robinson, KN Markvicheva, L Blanchet, LC Gomes, LK Huang, M Benhar, M Bociąga-Jasik, M Caron, M Conte Lo, M Forkink, M Fujikawa, M Giorgio, M Gutscher, M Gutscher, M Lebiedzinska, M Marí, M Zheng, MCY Chang, MG Traber, MJ Saaranen, MM Frigault, MM Tarpey, MP Murphy, MP Murphy, N Castelein, NM Mishina, O Touzet, P Back, P Lopert, P Matarrese, PHGM Willems, PK Sahoo, R Boer de, R Dixit, R Franco, R Radi, RA Weisiger, RB Hamanaka, RJ Mailloux, RL Smith, RR Bartz, S Chandra, S Dupre-Crochet, S Marchi, S Miwa, S Sachdev, S Topell, S Verkaart, SC Gupta, SG Rhee, SI Dikalov, SL Archer, SS Korshunov, T Finkel, T Nakamura, T Roumier, T Sieprath, T Sieprath, T Xiang, TA Prime, TZ Yu, VLRM Verstraeten, VV Belousov, W Naderi, WH Vos De, WJH Koopman, WJH Koopman, WJH Koopman, WJH Koopman, X Wang, Y Riahi, Z-H Chen   +130 more
core   +2 more sources

PRIMARY (GENETICALLY DETERMINED) DILATION CARDIOMYOPATHY IN A PATIENT WITH NOVEL MUTATION OF LAMIN GENE: CLINICAL AND MORPHOLOGICAL MANAGEMENT

Кардиоваскулярная терапия и профилактика, 2017
The primary diagnosis of “dilation cardiomyopathy” is syndromal, and demands clarification of nosological origins. In the article, the specifics of such diagnostics is discussed.
O. V. Blagova, I. N. Alieva, A. V. Nedostup, V. A. Sulimov, E. A. Kogan, A. G. Shestak, D. A. Zateyshchikov, E. V. Zaklyazminskaya   +7 more
doaj   +1 more source

Consequences of Lmna Exon 4 Mutations in Myoblast Function

Cells, 2020
Laminopathies are causally associated with mutations on the Lamin A/C gene (LMNA). To date, more than 400 mutations in LMNA have been reported in patients.
Déborah Gómez-Domínguez, Carolina Epifano, Fernando de Miguel, Albert García Castaño, Borja Vilaplana-Martí, Alberto Martín, Sandra Amarilla-Quintana, Anne T Bertrand, Gisèle Bonne, Javier Ramón-Azcón, Miguel A Rodríguez-Milla, Ignacio Pérez de Castro   +11 more
doaj   +1 more source

The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence [PDF]

, 2016
AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression.
Astrologo, Letizia, Biroccio, Annamaria, Burla, Romina, Carcuro, Mariateresa, Crescenzi, Marco, Cundari, Enrico, D'Apice, Maria Rosaria, Fratini, Federica, Gatti, Maurizio, LA TORRE, Mattia, Lattanzi, Giovanna, Raffa, GRAZIA DANIELA, Raimondo, Domenico, Saggio, Isabella, Spitalieri, Paola   +14 more
core   +2 more sources

Mouse models of the laminopathies [PDF]

Experimental Cell Research, 2007
The A and B type lamins are nuclear intermediate filament proteins that comprise the bulk of the nuclear lamina, a thin proteinaceous structure underlying the inner nuclear membrane. The A type lamins are encoded by the lamin A gene (LMNA). Mutations in this gene have been linked to at least nine diseases, including the progeroid diseases Hutchinson ...
Colin L, Stewart, Serguei, Kozlov, Loren G, Fong, Stephen G, Young   +3 more
openaire   +2 more sources

In silico synchronization reveals regulators of nuclear ruptures in lamin A/C deficient model cells [PDF]

, 2016
The nuclear lamina is a critical regulator of nuclear structure and function. Nuclei from laminopathy patient cells experience repetitive disruptions of the nuclear envelope, causing transient intermingling of nuclear and cytoplasmic components.
Corne, Tobias, De Vos, Winnok, Molenberghs, F, Robijns, J, Sieprath, Tom, Verschuuren, M   +5 more
core   +2 more sources

Structure and stability of the lamin A tail domain and HGPS mutant [PDF]

, 2011
Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging syndrome caused by the expression and accumulation of a mutant form of lamin A, Δ50 lamin A.
Buehler, Markus J, Dahl, Kris Noel, Kalinowski, Agnieszka, Qin, Zhao   +3 more
core   +1 more source

Thematic Review Series: Lipid Posttranslational Modifications. Prelamin A, Zmpste24, misshapen cell nuclei, and progeria—new evidence suggesting that protein farnesylation could be important for disease pathogenesis

Journal of Lipid Research, 2005
Prelamin A undergoes multistep processing to yield lamin A, a structural protein of the nuclear lamina. Prelamin A terminates with a CAAX motif, which triggers farnesylation of a C-terminal cysteine (the C of the CAAX motif), endoproteolytic release of ...
Stephen G. Young, Loren G. Fong, Susan Michaelis   +2 more
doaj   +1 more source

Structural and Mechanical Aberrations of the Nuclear Lamina in Disease

Cells, 2020
The nuclear lamins are the major components of the nuclear lamina in the nuclear envelope. Lamins are involved in numerous functions, including a role in providing structural support to the cell and the mechanosensing of the cell.
Merel Stiekema, Marc A. M. J. van Zandvoort, Frans C. S. Ramaekers, Jos L. V. Broers   +3 more
doaj   +1 more source

In memoriam: Kuan-Teh Jeang, MD PhD (1958–2013) [PDF]

, 2013
published_or_final_versio
Jin, D, Shi, YB, Wu, TC
core   +1 more source