Emerin expression stratification across breast cancer subtypes [PDF]
Cancer Treatment and Research CommunicationsNuclear dysmorphism is a critical indicator of tumor aggressiveness, influencing cancer cell invasion and metastasis. Emerin, an integral nuclear envelope protein involved in nuclear architecture, is important for maintaining nuclear integrity.
Thaysa Ghiarone +2 more
doaj +5 more sources
Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin–BAF Interaction and BAF Nuclear Localization [PDF]
Cells, 2020 Reactive Oxygen Species (ROS) are reactive molecules required for the maintenance of physiological functions. Oxidative stress arises when ROS production exceeds the cellular ability to eliminate such molecules.
Stefano Squarzoni +2 more
exaly +6 more sources
Emerin deficiency drives MCF7 cells to an invasive phenotype
Scientific ReportsDuring metastasis, cancer cells traverse the vasculature by squeezing through very small gaps in the endothelium. Thus, nuclei in metastatic cancer cells must become more malleable to move through these gaps.
James Holaska, Holaska James M
exaly +6 more sources
Frontiers in Cell and Developmental Biology, 2022 X-Linked Emery-Dreifuss muscular dystrophy is caused by mutations in the gene encoding emerin. Emerin is an inner nuclear membrane protein important for repressive chromatin organization at the nuclear periphery.
James Holaska +2 more
exaly +3 more sources
An Emerin LEM-Domain Mutation Impairs Cell Response to Mechanical Stress
Cells, 2019 Emerin is a nuclear envelope protein that contributes to genome organization and cell mechanics. Through its N-terminal LAP2-emerin-MAN1 (LEM)-domain, emerin interacts with the DNA-binding protein barrier-to-autointegration (BAF).
Ana Andréea Arteni +2 more
exaly +3 more sources
Cells, 2020 Mutations in the gene encoding emerin (EMD) cause Emery–Dreifuss muscular dystrophy (EDMD1), an inherited disorder characterized by progressive skeletal muscle wasting, irregular heart rhythms and contractures of major tendons.
James Holaska, Holaska James M
exaly +3 more sources
Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis [PDF]
Cell ReportsSummary: Neurons dynamically regulate their proteome in response to sensory input, a key process underlying experience-dependent plasticity. We characterized the visual experience-dependent nascent proteome in mice within a brief, defined time window ...
Yi Xie +8 more
doaj +2 more sources
ERM proteins support perinuclear actin rim formation [PDF]
Frontiers in Cell and Developmental BiologyThe interaction of actin filaments with the nuclear envelope is essential for diverse cellular processes, including cell migration, nuclear positioning, and transcriptional control.
Yuval Hadad +4 more
doaj +2 more sources
Mechanical-biochemical signaling accelerates scleral remodeling in myopia via the LaminA/C-Emerin-MKL1 axis [PDF]
Cell Communication and SignalingScleral remodeling is the pathological basis of axial elongation during the progression of myopia. However, the mechanism underlying the onset and progression of scleral remodeling remains unclear.
Yuying Liu +7 more
doaj +2 more sources
C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin [PDF]
eLifeThe inner nuclear membrane (INM), a subdomain of the endoplasmic reticulum (ER), sequesters hundreds of transmembrane proteins within the nucleus. We previously found that one INM protein, emerin, can evade the INM by secretory transport to the lysosome,
Jessica Mella +3 more
doaj +2 more sources