Results 1 to 10 of about 4,186 (177)

Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin–BAF Interaction and BAF Nuclear Localization [PDF]

Cells, 2020
Reactive Oxygen Species (ROS) are reactive molecules required for the maintenance of physiological functions. Oxidative stress arises when ROS production exceeds the cellular ability to eliminate such molecules.
Stefano Squarzoni, Cristina Capanni, Vittoria Cenni   +2 more
exaly   +7 more sources

Emerin deficiency drives MCF7 cells to an invasive phenotype [PDF]

Scientific Reports
During metastasis, cancer cells traverse the vasculature by squeezing through very small gaps in the endothelium. Thus, nuclei in metastatic cancer cells must become more malleable to move through these gaps.
Emily Hansen, Christal Rolling, Matthew Wang, James M. Holaska   +3 more
exaly   +7 more sources

Emerin expression stratification across breast cancer subtypes [PDF]

Cancer Treatment and Research Communications
Nuclear dysmorphism is a critical indicator of tumor aggressiveness, influencing cancer cell invasion and metastasis. Emerin, an integral nuclear envelope protein involved in nuclear architecture, is important for maintaining nuclear integrity.
Thaysa Ghiarone, Emily Hansen, James M. Holaska   +2 more
doaj   +5 more sources

Elevation of the mechanically-sensitive protein emerin links nuclear mechanotransduction to tau-induced cytoskeletal remodeling in neurons [PDF]

Nucleus
Neurodegenerative tauopathies, including Alzheimer’s disease, are neuropathologically defined by pathological tau deposition. While tau drives neurotoxicity by disrupting cytoskeletal, nucleoskeletal, and genomic architecture, cellular mechanisms ...
Claira Sohn, Sammy Pardo, Dana Molleur, Satvik R. Paduri, Morgan Lambert, Zachary Uttke, Erich J. Sohn, Morgan G. Thomas, Susan T. Weintraub, Bess Frost   +9 more
doaj   +2 more sources

Essential Role for Telomeric Repeat-Binding Factor 2 in Cardiac Development and Function. [PDF]

FASEB Bioadv
This schematic illustrates a paradigm shift in telomere biology, demonstrating that Trf2 is a mandatory orchestrator of heart development and function through pathways distinct from its canonical telomere protective role. ABSTRACT Telomere repeat‐binding factor 2 (Trf2) is essential for protecting our telomeres.
Hakim Shoushtari A, Danis A, Stoner MW, Baust J, Sebastiani A, Bugga P, Manning JR, Mushala BAS, Bhattarai N, Al Ghouleh I, Scott I, Sharifi-Sanjani M.   +11 more
europepmc   +2 more sources

Emerin acts as a mechanosensor linking force transmission and disease [PDF]

Frontiers in Oncology
For cells to respond to mechanical and biochemical cues in their environment, signals from the extracellular environment must be transmitted across the plasma membrane and into the nucleus to create the correct physical, transcriptional, and biochemical ...
Emily Hansen, Emily Hansen, James M. Holaska, James M. Holaska   +3 more
doaj   +2 more sources

Current Topics of Progressive Cardiac Conduction Disease. [PDF]

J Arrhythm
Many genes and the protein cause PCCD. Mutation of NaV1.5 or CX40 cause isolated PCCD, but mutation of lamin A/C, emerin, or desmin lead to cardiomyopathy, and PCCD. Mutation of transcription factor NCX2‐5, and Tbx5 associated with atrial septal defect and abnormal development of conduction system.
Sumitomo N, Mori H, Kumamoto T, Ishikawa T, Seki A, Makita N, Schott JJ, Wilde AAM.   +7 more
europepmc   +2 more sources

Emerin is necessary for microtubule-organizing center translocation to the nuclear envelope of muscle cells [PDF]

Cell Death and Disease
During myogenic differentiation, the Microtubule-Organizing Center (MTOC) is relocated to the nuclear envelope by a molecular platform including Linker of Nucleoskeleton and Cytoskeleton (LINC) complex proteins, A Kinase Anchoring Proteins (AKAP9 and ...
Elisabetta Mattioli, Vittoria Cenni, Patrizia Sabatelli, Elisa Schena, Spartaco Santi, Chiara Fiorillo, Claudio Bruno, Antonella Pini, Melania Giannotta, Marco Cavallo, Costantino Errani, Eleonora Cattin, Daniela Benati, Alessandra Recchia, Giovanna Lattanzi   +14 more
doaj   +2 more sources

Mechanical Stress Triggers Premature Senescence in Cardiac Fibroblasts. [PDF]

Adv Sci (Weinh)
Cellular senescence contributes to disease burden in cardiovascular disease (CVD) and aging, highlighting the need to understand its induction. In primary cardiac fibroblasts, reduced strain and increased frequency, mimicking CVD, elicit a distinct senescent phenotype compared to oxidative stress.
Schneider SE, Scott AK, Gallagher KM, Miller EY, Ghosh S, Neu CP.   +5 more
europepmc   +2 more sources

Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis [PDF]

Cell Reports
Summary: Neurons dynamically regulate their proteome in response to sensory input, a key process underlying experience-dependent plasticity. We characterized the visual experience-dependent nascent proteome in mice within a brief, defined time window ...
Yi Xie, Ruoxi Wang, Daniel B. McClatchy, Yuanhui Ma, Jolene Diedrich, Manuel Sanchez-Alavez, Michael Petrascheck, John R. Yates, III, Hollis T. Cline   +8 more
doaj   +2 more sources