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Cells, 2017 Mutations in the gene encoding emerin cause Emery-Dreifuss muscular dystrophy (EDMD), a disorder causing progressive skeletal muscle wasting, irregular heart rhythms and contractures of major tendons.
Ashvin Iyer +2 more
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Distribution of emerin during the cell cycle
European Journal of Cell Biology, 1999 Human emerin is a nuclear membrane protein that is lost or altered in patients with Emery-Dreifuss muscular dystrophy (EMD). While the protein is expressed in the majority of human tissues analyzed, the pathology predominates in cardiac and skeletal muscles of patients with EMD.
M C, Dabauvalle +5 more
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The nuclear envelope LEM-domain protein emerin [PDF]
Nucleus, 2013 Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for which extensive basic knowledge--biochemistry, partners, functions, localizations, posttranslational regulation, roles in development and links to human disease--is available.
Berk, Jason M +2 more
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The effects of swimming training on N-cadherin, β-catenin and Emerin in cardiac left ventricle of male Wistar rat [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2020 Background: Physical activity and exercise training plays a protective role against cardiovascular disease via reducing risk factors. Swimming as one of the best aerobic activity and exercise modality recommended for preventing and treatment of ...
Masoumeh Asadi +2 more
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Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus
BMC Molecular and Cell Biology, 2019 Background Nuclear lamins are type V intermediate filament proteins that maintain nuclear structure and function. Furthermore, Emerin - an interactor of Lamin A/C, facilitates crosstalk between the cytoskeleton and the nucleus as it also interacts with ...
Devika Ranade +4 more
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Journal of Physiological Sciences, 2023 Emery–Dreifuss muscular dystrophy (EDMD), caused by mutations in genes encoding nuclear envelope proteins, is clinically characterized by muscular dystrophy, early joint contracture, and life-threatening cardiac abnormalities.
Eiji Wada +4 more
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mBio, 2021 Ebola virus (EBOV) VP24 protein is a nucleocapsid-associated protein that inhibits interferon (IFN) gene expression and counteracts the IFN-mediated antiviral response, preventing nuclear import of signal transducer and activator of transcription 1 ...
Santiago Vidal +13 more
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Barrier-to-Autointegration Factor Phosphorylation on Ser-4 Regulates Emerin Binding to Lamin A In Vitro and Emerin Localization In Vivo [PDF]
Molecular Biology of the Cell, 2006 Barrier-to-autointegration factor (BAF) is a conserved 10-kDa chromatin protein essential in proliferating cells. BAF dimers bind double-stranded DNA, histone H3, histone H1.1, lamin A, and transcription regulators, plus emerin and other LEM-domain nuclear proteins.
Luiza, Bengtsson, Katherine L, Wilson
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Mechanical Properties of the Cell Nucleus and the Effect of Emerin Deficiency [PDF]
Biophysical Journal, 2006 Nuclear structure and mechanics are gaining recognition as important factors that affect gene expression, development, and differentiation in normal function and disease, yet the physical mechanisms that govern nuclear mechanical stability remain unclear.
Rowat, A.C. +2 more
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Emerin hooks centrosome to nucleus [PDF]
The Journal of Cell Biology, 2007 Cells lacking emerin, one of the proteins whose loss causes a form of muscular dystrophy, cannot hook their centrosome to the nucleus, show Salpingidou et al. The lost linkage might weaken contractile cells, including those diseased muscles. Figure 1 Centrosomes (arrowheads) stray from the nucleus if emerin is missing (bottom). Besides
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