Results 21 to 30 of about 4,186 (177)

Both emerin and lamin C depend on lamin A for localization at the nuclear envelope [PDF]

, 2001
Physical interactions between lamins and emerin were investigated by co-immunoprecipitation of in vitro translated proteins. Emerin interacted with in vitro translated lamins A, B1 and C in co-immunprecipitation reactions.
Whitfield, WGF, Vaughan, A, Hutchison, CJ, Wehnert, M, Bridger, JM, Morris, GE, Broers, JL, Raemakers, FC, Alvarez-Reyes, M   +8 more
core   +9 more sources

C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin [PDF]

eLife
The inner nuclear membrane (INM), a subdomain of the endoplasmic reticulum (ER), sequesters hundreds of transmembrane proteins within the nucleus. We previously found that one INM protein, emerin, can evade the INM by secretory transport to the lysosome,
Jessica Mella, Regan F Volk, Balyn W Zaro, Abigail Buchwalter   +3 more
doaj   +2 more sources

Profibrotic Molecules Are Reduced in CRISPR-Edited Emery–Dreifuss Muscular Dystrophy Fibroblasts [PDF]

Cells
Emery–Dreifuss muscular dystrophy (EDMD) is caused by mutations in EMD, LMNA, SYNE1, SYNE2, and other related genes. The disease is characterized by joint contractures, muscle weakening and wasting, and heart conduction defects associated with dilated ...
Eleonora Cattin, Elisa Schena, Elisabetta Mattioli, Stefania Marcuzzo, Silvia Bonanno, Paola Cavalcante, Federico Corradi, Daniela Benati, Giorgia Farinazzo, Marco Cattaneo, Veronica De Sanctis, Roberto Bertorelli, Lorenzo Maggi, Melania Giannotta, Antonella Pini, Gaetano Vattemi, Denise Cassandrini, Marco Cavallo, Cristina Manferdini, Gina Lisignoli, Beatrice Fontana, Ilaria Pace, Claudio Bruno, Roberta Roncarati, Chiara Fiorillo, Manuela Ferracin, Eric C. Schirmer, Alessandra Recchia, Giovanna Lattanzi   +28 more
doaj   +2 more sources

Emerin interacts with histone methyltransferases to regulate repressive chromatin at the nuclear periphery

Frontiers in Cell and Developmental Biology, 2022
X-Linked Emery-Dreifuss muscular dystrophy is caused by mutations in the gene encoding emerin. Emerin is an inner nuclear membrane protein important for repressive chromatin organization at the nuclear periphery.
Nicholas Marano, James M. Holaska
doaj   +1 more source

Role of Emerin in regulating fibroblast differentiation and migration at the substrate of stiffness coupled topology

Acta Biochimica et Biophysica Sinica
In hypertrophic scars, the differentiation and migration of fibroblasts are influenced by the extracellular matrix microenvironment, which includes factors such as stiffness, restraint, and tensile force.
Yang Tiantian, Wang Li, Ma Haiyang, Li Kailun, Wang Yajing, Tang Wenjie, Wang Zichen, An Meiwen, Gao Xiang, Xu Ludan, Guo Yunyun, Guo Jiqiang, Liu Yong, Wang Hugen, Liu Yang, Zhang Quanyou   +15 more
doaj   +2 more sources

Loss of emerin alters myogenic signaling and miRNA expression in mouse myogenic progenitors. [PDF]

PLoS ONE, 2012
Emerin is an integral membrane protein of the inner nuclear membrane. Mutations in emerin cause X-linked Emery-Dreifuss muscular dystrophy (EDMD), a disease characterized by skeletal muscle wasting and dilated cardiomyopathy.
Adam J Koch, James M Holaska
doaj   +1 more source

EDMD-Causing Emerin Mutant Myogenic Progenitors Exhibit Impaired Differentiation Using Similar Mechanisms

Cells, 2020
Mutations in the gene encoding emerin (EMD) cause Emery–Dreifuss muscular dystrophy (EDMD1), an inherited disorder characterized by progressive skeletal muscle wasting, irregular heart rhythms and contractures of major tendons.
Ashvin Iyer, James M. Holaska
doaj   +1 more source

Identification of PP2A-B55 targets uncovers regulation of emerin during nuclear envelope reassembly in Drosophila

Open Biology, 2023
Mitotic exit requires the dephosphorylation of many proteins whose phosphorylation was needed for mitosis. Protein phosphatase 2A with its B55 regulatory subunit (PP2A-B55) promotes this transition.
Virginie Emond-Fraser, Myreille Larouche, Peter Kubiniok, Éric Bonneil, Jingjing Li, Mohammed Bourouh, Laura Frizzi, Pierre Thibault, Vincent Archambault   +8 more
doaj   +1 more source

Emerin—prelamin A interplay in human fibroblasts [PDF]

Biology of the Cell, 2009
Background information. Emerin is a nuclear envelope protein that contributes to nuclear architecture, chromatin structure, and gene expression through its interaction with various nuclear proteins. In particular, emerin is molecularly connected with the nuclear lamina, a protein meshwork composed of lamins and lamin‐binding proteins underlying the ...
Capanni C, Del Coco R, Mattioli E, Camozzi D, Columbaro M, Schena E, Merlini L, Squarzoni S, Maraldi NM, Lattanzi G   +9 more
openaire   +3 more sources

Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes [PDF]

Human Molecular Genetics, 2006
X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) is inherited through mutations in emerin, a nuclear membrane protein. Emerin has proposed roles in nuclear architecture and gene regulation, but direct molecular links to disease were unknown. We report that Lim-domain only 7 (Lmo7) binds emerin directly with 125 nM affinity; the C-terminal half of ...
James M, Holaska, Soroush, Rais-Bahrami, Katherine L, Wilson   +2 more
openaire   +2 more sources