Results 21 to 30 of about 4,236 (177)

Emerin is necessary for microtubule-organizing center translocation to the nuclear envelope of muscle cells [PDF]

Cell Death and Disease
During myogenic differentiation, the Microtubule-Organizing Center (MTOC) is relocated to the nuclear envelope by a molecular platform including Linker of Nucleoskeleton and Cytoskeleton (LINC) complex proteins, A Kinase Anchoring Proteins (AKAP9 and ...
Elisabetta Mattioli, Vittoria Cenni, Patrizia Sabatelli, Elisa Schena, Spartaco Santi, Chiara Fiorillo, Claudio Bruno, Antonella Pini, Melania Giannotta, Marco Cavallo, Costantino Errani, Eleonora Cattin, Daniela Benati, Alessandra Recchia, Giovanna Lattanzi   +14 more
doaj   +2 more sources

EDMD-Causing Emerin Mutant Myogenic Progenitors Exhibit Impaired Differentiation Using Similar Mechanisms

Cells, 2020
Mutations in the gene encoding emerin (EMD) cause Emery–Dreifuss muscular dystrophy (EDMD1), an inherited disorder characterized by progressive skeletal muscle wasting, irregular heart rhythms and contractures of major tendons.
James M Holaska
exaly   +3 more sources

Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane.

PLoS Biology, 2004
X-linked Emery-Dreifuss muscular dystrophy is caused by loss of emerin, a LEM-domain protein of the nuclear inner membrane. To better understand emerin function, we used affinity chromatography to purify emerin-binding proteins from nuclear extracts of ...
James M Holaska, Amy K Kowalski, Katherine L Wilson   +2 more
doaj   +2 more sources

Diffusion-driven self-assembly of emerin nanodomains at the nuclear envelope [PDF]

Physical Review Research
Emerin, a nuclear membrane protein with important biological roles in mechanotransduction and nuclear shape adaptation, self-assembles into nanometer-size domains at the inner nuclear membrane.
Carlos D. Alas, Liying Wu, Fabien Pinaud, Christoph A. Haselwandter   +3 more
doaj   +3 more sources

Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis [PDF]

Cell Reports
Summary: Neurons dynamically regulate their proteome in response to sensory input, a key process underlying experience-dependent plasticity. We characterized the visual experience-dependent nascent proteome in mice within a brief, defined time window ...
Yi Xie, Ruoxi Wang, Daniel B. McClatchy, Yuanhui Ma, Jolene Diedrich, Manuel Sanchez-Alavez, Michael Petrascheck, John R. Yates, III, Hollis T. Cline   +8 more
doaj   +2 more sources

ERM proteins support perinuclear actin rim formation [PDF]

Frontiers in Cell and Developmental Biology
The interaction of actin filaments with the nuclear envelope is essential for diverse cellular processes, including cell migration, nuclear positioning, and transcriptional control.
Yuval Hadad, Andrea Fracchia, Dagmawit Babele, Amit Ben Shushan, Gabi Gerlitz   +4 more
doaj   +2 more sources

Both emerin and lamin C depend on lamin A for localization at the nuclear envelope [PDF]

, 2001
Physical interactions between lamins and emerin were investigated by co-immunoprecipitation of in vitro translated proteins. Emerin interacted with in vitro translated lamins A, B1 and C in co-immunprecipitation reactions.
Whitfield, WGF, Vaughan, A, Hutchison, CJ, Wehnert, M, Bridger, JM, Morris, GE, Broers, JL, Raemakers, FC, Alvarez-Reyes, M   +8 more
core   +8 more sources

Mechanical-biochemical signaling accelerates scleral remodeling in myopia via the LaminA/C-Emerin-MKL1 axis [PDF]

Cell Communication and Signaling
Scleral remodeling is the pathological basis of axial elongation during the progression of myopia. However, the mechanism underlying the onset and progression of scleral remodeling remains unclear.
Yuying Liu, Xin Liu, Mingming Liu, Xuetong Wang, Wenzhe Qian, Ting Zhao, Min Li, Bilian Ke   +7 more
doaj   +2 more sources

The Role of HOP in Emerin-Mediated Nuclear Structure [PDF]

, 2021
A vital component of the integral nuclear membrane is emerin, a Lamin Emerin and Man1 (LEM) domain protein whose concentration determines the levels of partner proteins that together constitute the structure of the nuclear envelope. Deficiencies in any of these proteins causes the failure of the structure and assembly and disassembly of the nuclear ...
Kituyi, Sarah Naulikha, Sarah Naulikha Kituyi, null null   +2 more
openaire   +2 more sources

Emerin self‐assembly mechanism: role of the LEM domain [PDF]

The FEBS Journal, 2017
At the nuclear envelope, the inner nuclear membrane protein emerin contributes to the interface between the nucleoskeleton and the chromatin. Emerin is an essential actor of the nuclear response to a mechanical signal. Genetic defects in emerin cause Emery–Dreifuss muscular dystrophy. It was proposed that emerin oligomerization regulates nucleoskeleton
Samson, Camille, Celli, Florian, Hendriks, Kitty, Zinke, Maximilian, Essawy, Nada, Herrada, Isaline, Arteni, Ana‐andreea, Theillet, Francois-Xavier, Alpha‐bazin, Béatrice, Armengaud, J., Coirault, Catherine, Lange, Adam, Zinn‐Justin, Sophie   +12 more
openaire   +4 more sources