Results 21 to 30 of about 6,334 (202)

HSV-1 US3: A Master Mimic Hijacking Host Kinase Networks for Viral Dominance. [PDF]

J Med Virol
ABSTRACT Herpes simplex virus type 1 (HSV‐1) encodes the serine/threonine kinase US3, a central regulator of host–virus interactions that promotes viral replication, latency, and reactivation. Despite limited sequence homology to cellular kinases such as Akt or PKA, US3 phosphorylates diverse substrates to manipulate multiple pathways.
Hossain I, Nelson CJ, Dutta O, Mohan H, Hasan M, Kousoulas KG.   +5 more
europepmc   +2 more sources

Emerin—prelamin A interplay in human fibroblasts [PDF]

Biology of the Cell, 2009
Background information. Emerin is a nuclear envelope protein that contributes to nuclear architecture, chromatin structure, and gene expression through its interaction with various nuclear proteins. In particular, emerin is molecularly connected with the nuclear lamina, a protein meshwork composed of lamins and lamin‐binding proteins underlying the ...
Capanni C, Del Coco R, Mattioli E, Camozzi D, Columbaro M, Schena E, Merlini L, Squarzoni S, Maraldi NM, Lattanzi G   +9 more
openaire   +3 more sources

Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations [PDF]

, 2005
Gene-poor human chromosomes are reproducibly found at the nuclear periphery in proliferating cells. There are a number of inner nuclear envelope proteins that may have roles in chromosome location and anchorage, e.g. emerin and A-type lamins.
Bridger, JM, Levy, N, Meaburn, KJ, Toniolo, D   +3 more
core   +1 more source

Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes [PDF]

Human Molecular Genetics, 2006
X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) is inherited through mutations in emerin, a nuclear membrane protein. Emerin has proposed roles in nuclear architecture and gene regulation, but direct molecular links to disease were unknown. We report that Lim-domain only 7 (Lmo7) binds emerin directly with 125 nM affinity; the C-terminal half of ...
James M, Holaska, Soroush, Rais-Bahrami, Katherine L, Wilson   +2 more
openaire   +2 more sources

Emerin Is Required for Proper Nucleus Reassembly after Mitosis: Implications for New Pathogenetic Mechanisms for Laminopathies Detected in EDMD1 Patients

Cells, 2019
Emerin is an essential LEM (LAP2, Emerin, MAN1) domain protein in metazoans and an integral membrane protein associated with inner and outer nuclear membranes.
Magda Dubińska-Magiera, Katarzyna Kozioł, Magdalena Machowska, Katarzyna Piekarowicz, Daria Filipczak, Ryszard Rzepecki   +5 more
doaj   +1 more source

Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential [PDF]

Cancer Research, 2018
Abstract Abnormalities in nuclear shape are a well-known feature of cancer, but their contribution to malignant progression remains poorly understood. Here, we show that depletion of the cytoskeletal regulator, Diaphanous-related formin 3 (DIAPH3), or the nuclear membrane–associated proteins, lamin A/C, in prostate and breast cancer ...
Mariana Reis-Sobreiro, Jie-Fu Chen, Tatiana Novitskaya, Sungyong You, Samantha Morley, Kenneth Steadman, Navjot Kaur Gill, Adel Eskaros, Mirja Rotinen, Chia-Yi Chu, Leland W.K. Chung, Hisashi Tanaka, Wei Yang, Beatrice S. Knudsen, Hsian-Rong Tseng, Amy C. Rowat, Edwin M. Posadas, Andries Zijlstra, Dolores Di Vizio, Michael R. Freeman   +19 more
openaire   +3 more sources

Negative correlation between the nuclear size and nuclear Lamina component Lamin A in intraductal papillary mucinous neoplasms of the pancreas

Pathology and Oncology Research, 2022
Background: The nuclear laminar protein Lamin A and inner nuclear membrane protein Emerin plays important role in sustaining nuclear structure. However, They have not investigated the significance of these proteins for development of pancreatic ...
Tamaki Hiroe, Shunichi Moriya, Sayaka Kobayashi, Yoshimi Nishijima, Akira Watanabe, Ken Shirabe, Hayato Ikota, Hideaki Yokoo, Masanao Saio   +8 more
doaj   +1 more source

Emerin intermolecular links to emerin and BAF

Journal of Cell Science, 2014
Emerin is a conserved nuclear membrane LEM-domain protein that binds lamins and BAF (barrier-to-integration factor; BANF1) as a component of nuclear lamina structure. We report an advance in understanding the molecular basis of emerin function: inter-molecular emerin-emerin association.
Jason M. Berk, Dan N. Simon, Clifton R. Jenkins-Houk, Jason W. Westerbeck, Line M. Grønning-Wang, Cathrine R. Carlson, Katherine L. Wilson   +6 more
openaire   +2 more sources

Comparative Interactome Analysis of Emerin, MAN1 and LEM2 Reveals a Unique Role for LEM2 in Nucleotide Excision Repair

Cells, 2020
LAP2-Emerin-MAN1 (LEM) domain-containing proteins represent an abundant group of inner nuclear membrane proteins involved in diverse nuclear functions, but their functional redundancies remain unclear.
Bernhard Moser, José Basílio, Josef Gotzmann, Andreas Brachner, Roland Foisner   +4 more
doaj   +1 more source

Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane.

PLoS Biology, 2004
X-linked Emery-Dreifuss muscular dystrophy is caused by loss of emerin, a LEM-domain protein of the nuclear inner membrane. To better understand emerin function, we used affinity chromatography to purify emerin-binding proteins from nuclear extracts of ...
James M Holaska, Amy K Kowalski, Katherine L Wilson   +2 more
doaj   +1 more source