Results 1 to 10 of about 64,746 (288)

Mitochondrial stress response and myogenic differentiation [PDF]

Frontiers in Cell and Developmental Biology
Regeneration and repair are prerequisites for maintaining effective function of skeletal muscle under high energy demands, and myogenic differentiation is one of the key steps in the regeneration and repair process.
Fu Lin, Liankun Sun, Yu Zhang, Weinan Gao, Zihan Chen, Zihan Chen, Yanan Liu, Kai Tian, Kai Tian, Xuyu Han, Xuyu Han, Ruize Liu, Ruize Liu, Yang Li, Luyan Shen   +14 more
doaj   +4 more sources

Decrotonylation of AKT1 promotes AKT1 phosphorylation and activation during myogenic differentiation

Journal of Advanced Research, 2023
Introduction: Myogenic differentiation plays an important role in pathophysiological processes including muscle injury and regeneration, as well as muscle atrophy. A novel type of posttranslational modification, crotonylation, has been reported to play a
Zhengyu Qian, Jingwei Ye, Jinteng Li, Yunshu Che, Wenhui Yu, Peitao Xu, Jiajie Lin, Feng Ye, Xiaojun Xu, Zepeng Su, Dateng Li, Zhongyu Xie, Yanfeng Wu, Huiyong Shen   +13 more
doaj   +3 more sources

ROS-Drp1-mitophagy feedback loop regulates myogenic differentiation via actin cytoskeleton remodeling-mediated MRTF-A/SRF axis [PDF]

Redox Report
Background Mitochondrial division is one of the main characteristics for the initiation of myogenic differentiation. However, the role and mechanism of Dynamin-related protein 1 (Drp1), the most important protein that regulates mitochondrial fission in ...
Aiwen Jiang, Luyao Wang, Xinyu Liu, Jialong Li, Haifei Wang, Shenglong Wu, Wenbin Bao   +6 more
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Dynamic remodeling of septin structures fine-tunes myogenic differentiation [PDF]

iScience
Summary: Controlled myogenic differentiation is integral to the development, maintenance and repair of skeletal muscle, necessitating precise regulation of myogenic progenitors and resident stem cells.
Vladimir Ugorets, Paul-Lennard Mendez, Dmitrii Zagrebin, Giulia Russo, Yannic Kerkhoff, Georgios Kotsaris, Jerome Jatzlau, Sigmar Stricker, Petra Knaus   +8 more
doaj   +2 more sources

miR-9-5p promotes myogenic differentiation via the Dlx3/Myf5 axis [PDF]

PeerJ, 2022
MicroRNAs play an important role in myogenic differentiation, they bind to target genes and regulate muscle formation. We previously found that miR-9-5p, which is related to bone formation, was increased over time during the process of myogenic ...
Liying Dong, Meng Wang, Xiaolei Gao, Xuan Zheng, Yixin Zhang, Liangjie Sun, Na Zhao, Chong Ding, Zeyun Ma, Yixiang Wang   +9 more
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Methyltransferase Dot1L promotes myogenic differentiation of skeletal muscle by regulating promoter methylation level

陆军军医大学学报, 2022
Objective To confirm whether methyltransferase Dot1L is involved in the regulation of myogenic differentiation, and explore its molecular mechanism in the regulation process.
LI Chengcheng, ZHOU Yong, LI Haoke, DENG Zhongliang   +3 more
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Hes6 Regulates Myogenic Differentiation [PDF]

Clinical Science, 2002
Hes6 is a basic helix-loop-helix transcription factor homologous to Drosophila Enhancer of Split (EoS) proteins. It is known to promote neural differentiation and to bind to Hes1, a related protein that is part of the Notch signalling pathway, affecting Hes1-regulated transcription.
Judy, Cossins, Ann E, Vernon, Yun, Zhang, Anna, Philpott, Philip H, Jones   +4 more
openaire   +2 more sources

Induction of miR-665-3p Impairs the Differentiation of Myogenic Progenitor Cells by Regulating the TWF1-YAP1 Axis

Cells, 2023
Actin dynamics are known to orchestrate various myogenic processes in progenitor cells. Twinfilin-1 (TWF1) is an actin-depolymerizing factor that plays a crucial role in the differentiation of myogenic progenitor cells. However, little is known about the
Mai Thi Nguyen, Wan Lee
doaj   +1 more source

Carbon metabolism–mediated myogenic differentiation [PDF]

Nature Chemical Biology, 2010
The role of nutrients and metabolism in cellular differentiation is poorly understood. Using RNAi screening, metabolic profiling and small-molecule probes, we discovered that the knockdown of three metabolic enzymes-phosphoglycerate kinase (Pgk1), hexose-6-phosphate dehydrogenase (H6pd) and ATP citrate lyase (Acl)-induces differentiation of mouse C2C12
Bracha, Abigail L., Ramanathan, Arvind, Huang, Sui, Ingber, Donald E., Schreiber, Stuart L.   +4 more
openaire   +2 more sources

EV-mediated promotion of myogenic differentiation is dependent on dose, collection medium, and isolation method

Molecular Therapy: Nucleic Acids, 2023
Extracellular vesicles (EVs) have been implicated in the regulation of myogenic differentiation. C2C12 murine myoblast differentiation was reduced following treatment with GW4869 or heparin (to inhibit exosome biogenesis and EV uptake, respectively ...
Britt Hanson, Ioulia Vorobieva, Wenyi Zheng, Mariana Conceição, Yulia Lomonosova, Imre Mäger, Pier Lorenzo Puri, Samir El Andaloussi, Matthew J.A. Wood, Thomas C. Roberts   +9 more
doaj   +1 more source