Results 1 to 10 of about 35,034 (158)

Mitochondrial stress response and myogenic differentiation [PDF]

Frontiers in Cell and Developmental Biology
Regeneration and repair are prerequisites for maintaining effective function of skeletal muscle under high energy demands, and myogenic differentiation is one of the key steps in the regeneration and repair process.
Fu Lin, Liankun Sun, Yu Zhang, Weinan Gao, Zihan Chen, Zihan Chen, Yanan Liu, Kai Tian, Kai Tian, Xuyu Han, Xuyu Han, Ruize Liu, Ruize Liu, Yang Li, Luyan Shen   +14 more
doaj   +6 more sources

Decrotonylation of AKT1 promotes AKT1 phosphorylation and activation during myogenic differentiation

Journal of Advanced Research, 2023
Introduction: Myogenic differentiation plays an important role in pathophysiological processes including muscle injury and regeneration, as well as muscle atrophy. A novel type of posttranslational modification, crotonylation, has been reported to play a
Zhengyu Qian, Jingwei Ye, Jinteng Li, Yunshu Che, Wenhui Yu, Peitao Xu, Jiajie Lin, Feng Ye, Xiaojun Xu, Zepeng Su, Dateng Li, Zhongyu Xie, Yanfeng Wu, Huiyong Shen   +13 more
doaj   +3 more sources

EV-mediated promotion of myogenic differentiation is dependent on dose, collection medium, and isolation method

Molecular Therapy: Nucleic Acids, 2023
Extracellular vesicles (EVs) have been implicated in the regulation of myogenic differentiation. C2C12 murine myoblast differentiation was reduced following treatment with GW4869 or heparin (to inhibit exosome biogenesis and EV uptake, respectively ...
Britt Hanson, Ioulia Vorobieva, Wenyi Zheng, Mariana Conceição, Yulia Lomonosova, Imre Mäger, Pier Lorenzo Puri, Samir El Andaloussi, Matthew J.A. Wood, Thomas C. Roberts   +9 more
doaj   +3 more sources

TEAD4 Promotes Myogenic Differentiation of Porcine Skeletal Muscle Satellite Cells [PDF]

Animals
Skeletal muscle satellite cells are indispensable for muscle growth and regeneration, and their myogenic differentiation is precisely controlled by transcription factors.
Huanhuan Zhou, Jiayi Zeng, Xiaoyu Zhang, Xinqi Zeng, Ke Xu, Hongbo Chen   +5 more
doaj   +2 more sources

JAK-STAT pathway and myogenic differentiation [PDF]

Jak-stat, 2013
Myogenic differentiation plays an important role in muscle regeneration and is regulated by two transcription factor families, MRFs and MEF2, which induce differentiation of myoblasts through expression of the muscle-specific gene, myogenin. In addition, many intracellular signaling pathways are also involved in myogenic differentiation, including p38 ...
Jang, You-Na, Baik, Eun Joo
exaly   +3 more sources

Involvement of DPY19L3 in Myogenic Differentiation of C2C12 Myoblasts [PDF]

Molecules, 2021
DPY19L3 has been identified as a C-mannosyltransferase for thrombospondin type-1 repeat domain-containing proteins. In this study, we focused on the role of DPY19L3 in the myogenic differentiation of C2C12 mouse myoblast cells. We carried out DPY19L3 gene depletion using the CRISPR/Cas9 system.
Kazuki Miura, Siro Simizu
exaly   +4 more sources

ROS-Drp1-mitophagy feedback loop regulates myogenic differentiation via actin cytoskeleton remodeling-mediated MRTF-A/SRF axis [PDF]

Redox Report
Background Mitochondrial division is one of the main characteristics for the initiation of myogenic differentiation. However, the role and mechanism of Dynamin-related protein 1 (Drp1), the most important protein that regulates mitochondrial fission in ...
Aiwen Jiang, Luyao Wang, Xinyu Liu, Jialong Li, Haifei Wang, Shenglong Wu, Wenbin Bao   +6 more
doaj   +2 more sources

LMOD2 interaction with ACTC1 regulates myogenic differentiation. [PDF]

BMC Genomics
Skeletal muscle is the largest tissue in mammals, and it plays a crucial role in metabolism and homeostasis. Skeletal muscle development and regeneration consist of a series of carefully regulated changes in gene expression. Leiomodin2 (LMOD2) gene is specifically expressed in the heart and skeletal muscle.
Wang K, Liu C, Yi L, Liufu S, Chen W, Liu X, Chen B, Xu X, Liu J, Liu X, Yin Y, Ma H.   +11 more
europepmc   +3 more sources

Dynamic remodeling of septin structures fine-tunes myogenic differentiation [PDF]

iScience
Summary: Controlled myogenic differentiation is integral to the development, maintenance and repair of skeletal muscle, necessitating precise regulation of myogenic progenitors and resident stem cells.
Vladimir Ugorets, Paul-Lennard Mendez, Dmitrii Zagrebin, Giulia Russo, Yannic Kerkhoff, Georgios Kotsaris, Jerome Jatzlau, Sigmar Stricker, Petra Knaus   +8 more
doaj   +2 more sources

Arsenic Inhibits Myogenic Differentiation and Muscle Regeneration

Environmental Health Perspectives, 2010
The incidence of low birth weights is increased in offspring of women who are exposed to high concentrations of arsenic in drinking water compared with other women. We hypothesized that effects of arsenic on birth weight may be related to effects on myogenic differentiation.We investigated the effects of arsenic trioxide (As2O3) on the myogenic ...
Keh-Sung Tsai, Chun-Fa Huang, Rong-Sen Yang   +2 more
exaly   +3 more sources