Results 1 to 10 of about 1,731 (66)

Decrotonylation of AKT1 promotes AKT1 phosphorylation and activation during myogenic differentiation

Journal of Advanced Research, 2023
Introduction: Myogenic differentiation plays an important role in pathophysiological processes including muscle injury and regeneration, as well as muscle atrophy. A novel type of posttranslational modification, crotonylation, has been reported to play a
Zhengyu Qian, Jingwei Ye, Jinteng Li, Yunshu Che, Wenhui Yu, Peitao Xu, Jiajie Lin, Feng Ye, Xiaojun Xu, Zepeng Su, Dateng Li, Zhongyu Xie, Yanfeng Wu, Huiyong Shen   +13 more
exaly   +3 more sources

EV-mediated promotion of myogenic differentiation is dependent on dose, collection medium, and isolation method

Molecular Therapy - Nucleic Acids, 2023
Extracellular vesicles (EVs) have been implicated in the regulation of myogenic differentiation. C2C12 murine myoblast differentiation was reduced following treatment with GW4869 or heparin (to inhibit exosome biogenesis and EV uptake, respectively ...
Thomas Roberts, Matthew Wood, Yulia Lomonosova   +2 more
exaly   +3 more sources

NANOG restores the impaired myogenic differentiation potential of skeletal myoblasts after multiple population doublings

Stem Cell Research, 2018
Adult skeletal muscle regeneration relies on the activity of satellite cells residing in the skeletal muscle niche. However, systemic and intrinsic factors decrease the myogenic differentiation potential of satellite cells thereby impairing muscle ...
Stelios T Andreadis, Aref Shahini, Pedro Lei   +2 more
exaly   +3 more sources

Mitochondrial stress response and myogenic differentiation

Frontiers in Cell and Developmental Biology
Regeneration and repair are prerequisites for maintaining effective function of skeletal muscle under high energy demands, and myogenic differentiation is one of the key steps in the regeneration and repair process.
Liankun Sun, Luyan Shen
exaly   +3 more sources

miR-9-5p promotes myogenic differentiation via the Dlx3/Myf5 axis [PDF]

PeerJ, 2022
MicroRNAs play an important role in myogenic differentiation, they bind to target genes and regulate muscle formation. We previously found that miR-9-5p, which is related to bone formation, was increased over time during the process of myogenic ...
Liying Dong, Meng Wang, Xiaolei Gao, Xuan Zheng, Yixin Zhang, Liangjie Sun, Na Zhao, Chong Ding, Zeyun Ma, Yixiang Wang   +9 more
doaj   +2 more sources

Methyltransferase Dot1L promotes myogenic differentiation of skeletal muscle by regulating promoter methylation level

陆军军医大学学报, 2022
Objective To confirm whether methyltransferase Dot1L is involved in the regulation of myogenic differentiation, and explore its molecular mechanism in the regulation process.
LI Chengcheng, ZHOU Yong, LI Haoke, DENG Zhongliang   +3 more
doaj   +1 more source

Induction of miR-665-3p Impairs the Differentiation of Myogenic Progenitor Cells by Regulating the TWF1-YAP1 Axis

Cells, 2023
Actin dynamics are known to orchestrate various myogenic processes in progenitor cells. Twinfilin-1 (TWF1) is an actin-depolymerizing factor that plays a crucial role in the differentiation of myogenic progenitor cells. However, little is known about the
Mai Thi Nguyen, Wan Lee
doaj   +1 more source

Stimulation of Non-canonical NF-κB Through Lymphotoxin-β-Receptor Impairs Myogenic Differentiation and Regeneration of Skeletal Muscle

Frontiers in Cell and Developmental Biology, 2021
Myogenic differentiation, muscle stem cell functionality, and regeneration of skeletal muscle are cellular processes under tight control of various signaling pathways.
Manuel Schmidt, Anja Weidemann, Christine Poser, Anne Bigot, Julia von Maltzahn   +4 more
doaj   +1 more source

Factors influencing myogenic differentiation of adipose-derived stem cells and their application in muscle regeneration

Chinese Journal of Plastic and Reconstructive Surgery, 2022
Skeletal muscle regeneration mainly depends on muscle satellite cells; however, these cells are not sufficient for supporting repair and regeneration in volumetric muscle loss (VML), Duchenne muscular dystrophy, and other muscle injuries or muscle ...
Na Liu, Guanhuier Wang, Yonghuan Zhen, Yujia Shang, Fangfei Nie, Lingjuan Zhu, Zhenmin Zhao, Yang An   +7 more
doaj   +1 more source

Notch signaling leads to a slower progression of embryonic myogenic differentiation in Landrace than in Langtang pigs

Acta Biochimica et Biophysica Sinica, 2022
Delving into porcine embryonic myogenesis is the key to elucidate the complex regulation of breed-specific differences in growth performance and meat production.
Cai Shufang, Hu Bin, Zhu Qi, Duo Tianqi, Wang Xiaoyu, Tong Xian, Luo Xiaorong, Yuan Renqiang, Chen Yaosheng, Wang Jing, Luo Chenglong, Xing Baosong, Mo Delin   +12 more
doaj   +1 more source