Results 21 to 30 of about 41,288 (271)

Hes6 Regulates Myogenic Differentiation [PDF]

Clinical Science, 2002
Hes6 is a basic helix-loop-helix transcription factor homologous to Drosophila Enhancer of Split (EoS) proteins. It is known to promote neural differentiation and to bind to Hes1, a related protein that is part of the Notch signalling pathway, affecting Hes1-regulated transcription.
Judy, Cossins, Ann E, Vernon, Yun, Zhang, Anna, Philpott, Philip H, Jones   +4 more
openaire   +2 more sources

mTORCing about myogenic differentiation [PDF]

Cell Cycle, 2014
The C2C12 myoblast cell line has been extensively studied as it has the potential to differentiate from serum-starved confluent monolayer cultures into myotubes, (Fig. 1, upper panel) which can further align and form muscle fibers. Furthermore, C2C12 myoblasts can differentiate into adipose and bone-type lineages, depending on the conditions present ...
Iadevaia, V, Cowan, JL, Coldwell, MJ
openaire   +3 more sources

Stimulation of Non-canonical NF-κB Through Lymphotoxin-β-Receptor Impairs Myogenic Differentiation and Regeneration of Skeletal Muscle

Frontiers in Cell and Developmental Biology, 2021
Myogenic differentiation, muscle stem cell functionality, and regeneration of skeletal muscle are cellular processes under tight control of various signaling pathways.
Manuel Schmidt, Anja Weidemann, Christine Poser, Anne Bigot, Julia von Maltzahn   +4 more
doaj   +1 more source

An initial blueprint for myogenic differentiation [PDF]

Genes & Development, 2005
We have combined genome-wide transcription factor binding and expression profiling to assemble a regulatory network controlling the myogenic differentiation program in mammalian cells. We identified a cadre of overlapping and distinct targets of the key myogenic regulatory factors (MRFs)—MyoD and myogenin—and Myocyte Enhancer Factor 2 (MEF2).
Alexandre, Blais, Mary, Tsikitis, Diego, Acosta-Alvear, Roded, Sharan, Yuval, Kluger, Brian David, Dynlacht   +5 more
openaire   +2 more sources

Notch signaling leads to a slower progression of embryonic myogenic differentiation in Landrace than in Langtang pigs

Acta Biochimica et Biophysica Sinica, 2022
Delving into porcine embryonic myogenesis is the key to elucidate the complex regulation of breed-specific differences in growth performance and meat production.
Cai Shufang, Hu Bin, Zhu Qi, Duo Tianqi, Wang Xiaoyu, Tong Xian, Luo Xiaorong, Yuan Renqiang, Chen Yaosheng, Wang Jing, Luo Chenglong, Xing Baosong, Mo Delin   +12 more
doaj   +1 more source

Factors influencing myogenic differentiation of adipose-derived stem cells and their application in muscle regeneration

Chinese Journal of Plastic and Reconstructive Surgery, 2022
Skeletal muscle regeneration mainly depends on muscle satellite cells; however, these cells are not sufficient for supporting repair and regeneration in volumetric muscle loss (VML), Duchenne muscular dystrophy, and other muscle injuries or muscle ...
Na Liu, Guanhuier Wang, Yonghuan Zhen, Yujia Shang, Fangfei Nie, Lingjuan Zhu, Zhenmin Zhao, Yang An   +7 more
doaj   +1 more source

Ryanodine receptor RyR1-mediated elevation of Ca2+ concentration is required for the late stage of myogenic differentiation and fusion

Journal of Animal Science and Biotechnology, 2022
Background Cytosolic Ca2+ plays vital roles in myogenesis and muscle development. As a major Ca2+ release channel of endoplasmic reticulum (ER), ryanodine receptor 1 (RyR1) key mutations are main causes of severe congenital myopathies.
Kai Qiu, Yubo Wang, Doudou Xu, Linjuan He, Xin Zhang, Enfa Yan, Lu Wang, Jingdong Yin   +7 more
doaj   +1 more source

Carbon metabolism–mediated myogenic differentiation [PDF]

Nature Chemical Biology, 2010
The role of nutrients and metabolism in cellular differentiation is poorly understood. Using RNAi screening, metabolic profiling and small-molecule probes, we discovered that the knockdown of three metabolic enzymes-phosphoglycerate kinase (Pgk1), hexose-6-phosphate dehydrogenase (H6pd) and ATP citrate lyase (Acl)-induces differentiation of mouse C2C12
Bracha, Abigail L., Ramanathan, Arvind, Huang, Sui, Ingber, Donald E., Schreiber, Stuart L.   +4 more
openaire   +2 more sources

Apol9a regulates myogenic differentiation via the ERK1/2 pathway in C2C12 cells

Frontiers in Pharmacology, 2022
Background: The rising prevalence of obesity and its complications is a big challenge for the global public health. Obesity is accompanied by biological dysfunction of skeletal muscle and the development of muscle atrophy.
Xuan Jiang, Xuan Jiang, Siyu Ji, Siyuan Cui, Rong Wang, Rong Wang, Wei Wang, Yongquan Chen, Yongquan Chen, Yongquan Chen, Shenglong Zhu, Shenglong Zhu   +11 more
doaj   +1 more source

Myostatin Mutation Enhances Bovine Myogenic Differentiation through PI3K/AKT/mTOR Signalling via Removing DNA Methylation of RACK1

Cells, 2022
Myostatin (MSTN) is a negative regulator of skeletal muscle development and plays an important role in muscle development. Fluctuations in gene expression influenced by DNA methylation are critical for homeostatic responses in muscle.
Yiping Zhao, Xiaoxia Xia, Qiaomeng Wang, Debao Hu, Linlin Zhang, Xin Li, Xiangbin Ding, Hong Guo, Yiwen Guo   +8 more
doaj   +1 more source