Results 21 to 30 of about 814,354 (242)

mTORCing about myogenic differentiation [PDF]

Cell Cycle, 2014
The C2C12 myoblast cell line has been extensively studied as it has the potential to differentiate from serum-starved confluent monolayer cultures into myotubes, (Fig. 1, upper panel) which can further align and form muscle fibers. Furthermore, C2C12 myoblasts can differentiate into adipose and bone-type lineages, depending on the conditions present ...
Iadevaia, V, Cowan, JL, Coldwell, MJ
openaire   +3 more sources

An initial blueprint for myogenic differentiation [PDF]

Genes & Development, 2005
We have combined genome-wide transcription factor binding and expression profiling to assemble a regulatory network controlling the myogenic differentiation program in mammalian cells. We identified a cadre of overlapping and distinct targets of the key myogenic regulatory factors (MRFs)—MyoD and myogenin—and Myocyte Enhancer Factor 2 (MEF2).
Alexandre, Blais, Mary, Tsikitis, Diego, Acosta-Alvear, Roded, Sharan, Yuval, Kluger, Brian David, Dynlacht   +5 more
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Carbon metabolism–mediated myogenic differentiation [PDF]

Nature Chemical Biology, 2010
The role of nutrients and metabolism in cellular differentiation is poorly understood. Using RNAi screening, metabolic profiling and small-molecule probes, we discovered that the knockdown of three metabolic enzymes-phosphoglycerate kinase (Pgk1), hexose-6-phosphate dehydrogenase (H6pd) and ATP citrate lyase (Acl)-induces differentiation of mouse C2C12
Bracha, Abigail L., Ramanathan, Arvind, Huang, Sui, Ingber, Donald E., Schreiber, Stuart L.   +4 more
openaire   +2 more sources

Ryanodine receptor RyR1-mediated elevation of Ca2+ concentration is required for the late stage of myogenic differentiation and fusion

Journal of Animal Science and Biotechnology, 2022
Background Cytosolic Ca2+ plays vital roles in myogenesis and muscle development. As a major Ca2+ release channel of endoplasmic reticulum (ER), ryanodine receptor 1 (RyR1) key mutations are main causes of severe congenital myopathies.
Kai Qiu, Yubo Wang, Doudou Xu, Linjuan He, Xin Zhang, Enfa Yan, Lu Wang, Jingdong Yin   +7 more
doaj   +1 more source

Integrated Functions of Pax3 and Pax7 in the Regulation of Proliferation, Cell Size and Myogenic Differentiation [PDF]

, 2009
Pax3 and Pax7 are paired-box transcription factors with roles in developmental and adult regenerative myogenesis. Pax3 and Pax7 are expressed by postnatal satellite cells or their progeny but are down regulated during myogenic differentiation.
Morgan, JE, Zammit, PS, Boldrin, L, Collins, C A, Robert B White, Peter S Zammit, White, R B, Relaix, F, Gnocchi, VF, Jennifer E Morgan, Ana Perez-Ruiz, Viola F Gnocchi, Frederic Relaix, Gnocchi, V F, Zammit, P S, Collins, CA, Charlotte A Collins, White, RB, Perez-Ruiz, A, Robert B. White, Jennifer E. Morgan, Viola F. Gnocchi, Morgan, J E, Luisa Boldrin, Peter S. Zammit, Charlotte A. Collins   +25 more
core   +1 more source

Apol9a regulates myogenic differentiation via the ERK1/2 pathway in C2C12 cells

Frontiers in Pharmacology, 2022
Background: The rising prevalence of obesity and its complications is a big challenge for the global public health. Obesity is accompanied by biological dysfunction of skeletal muscle and the development of muscle atrophy.
Xuan Jiang, Xuan Jiang, Siyu Ji, Siyuan Cui, Rong Wang, Rong Wang, Wei Wang, Yongquan Chen, Yongquan Chen, Yongquan Chen, Shenglong Zhu, Shenglong Zhu   +11 more
doaj   +1 more source

Myostatin Mutation Enhances Bovine Myogenic Differentiation through PI3K/AKT/mTOR Signalling via Removing DNA Methylation of RACK1

Cells, 2022
Myostatin (MSTN) is a negative regulator of skeletal muscle development and plays an important role in muscle development. Fluctuations in gene expression influenced by DNA methylation are critical for homeostatic responses in muscle.
Yiping Zhao, Xiaoxia Xia, Qiaomeng Wang, Debao Hu, Linlin Zhang, Xin Li, Xiangbin Ding, Hong Guo, Yiwen Guo   +8 more
doaj   +1 more source

Involvement of cdks and cyclins in muscle differentiation

European Journal of Histochemistry, 2009
Myocyte differentiation is due to transcription of genes that characterize the phenotypic and biochemical identity of differentiated muscle cells. These are the myogenic regulatory factors (MRFs) MyoD, Myf5, myogenin and MRF4.
M De Falco, A De Luca
doaj   +1 more source

FTO-mediated demethylation of GADD45B promotes myogenesis through the activation of p38 MAPK pathway

Molecular Therapy: Nucleic Acids, 2021
N6-methyladenosine (m6A) modification plays a critical role in mammalian development. However, the role of m6A in the skeletal muscle development remains largely unknown.
Kaiping Deng, Yixuan Fan, Yaxu Liang, Yu Cai, Guomin Zhang, Mingtian Deng, Zhibo Wang, Jiawei Lu, Jianfei Shi, Feng Wang, Yanli Zhang   +10 more
doaj   +1 more source

Myogenic Cell Proliferation and Differentiation

Poultry Science, 1991
It is generally thought that growth factors play a major role in regulating proliferation and differentiation of myogenic cells. Cell culture studies indicate that of the known growth factors, the fibroblast growth factors, the transforming growth factor beta, and the insulin-like growth factor families play the most significant roles in this process ...
W R, Dayton, M R, Hathaway
openaire   +2 more sources