Results 11 to 20 of about 37,236 (253)
Hes6 Regulates Myogenic Differentiation [PDF]
Clinical Science, 2002 Hes6 is a basic helix-loop-helix transcription factor homologous to Drosophila Enhancer of Split (EoS) proteins. It is known to promote neural differentiation and to bind to Hes1, a related protein that is part of the Notch signalling pathway, affecting Hes1-regulated transcription.
Judy, Cossins +4 more
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mTORCing about myogenic differentiation [PDF]
Cell Cycle, 2014 The C2C12 myoblast cell line has been extensively studied as it has the potential to differentiate from serum-starved confluent monolayer cultures into myotubes, (Fig. 1, upper panel) which can further align and form muscle fibers. Furthermore, C2C12 myoblasts can differentiate into adipose and bone-type lineages, depending on the conditions present ...
Iadevaia, V, Cowan, JL, Coldwell, MJ
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RIP2, a Checkpoint in Myogenic Differentiation [PDF]
Molecular and Cellular Biology, 2002 Using a subtractive cDNA library hybridization approach, we found that receptor interacting protein 2 (RIP2), a tumor necrosis factor receptor 1 (TNFR-1)-associated factor, is a novel early-acting gene that decreases markedly in expression during myogenic differentiation.
Barbara, Munz +3 more
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An initial blueprint for myogenic differentiation [PDF]
Genes & Development, 2005 We have combined genome-wide transcription factor binding and expression profiling to assemble a regulatory network controlling the myogenic differentiation program in mammalian cells. We identified a cadre of overlapping and distinct targets of the key myogenic regulatory factors (MRFs)—MyoD and myogenin—and Myocyte Enhancer Factor 2 (MEF2).
Alexandre, Blais +5 more
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Carbon metabolism–mediated myogenic differentiation [PDF]
Nature Chemical Biology, 2010 The role of nutrients and metabolism in cellular differentiation is poorly understood. Using RNAi screening, metabolic profiling and small-molecule probes, we discovered that the knockdown of three metabolic enzymes-phosphoglycerate kinase (Pgk1), hexose-6-phosphate dehydrogenase (H6pd) and ATP citrate lyase (Acl)-induces differentiation of mouse C2C12
Bracha, Abigail L. +4 more
openaire +2 more sources
Acta Biochimica et Biophysica Sinica, 2022 Delving into porcine embryonic myogenesis is the key to elucidate the complex regulation of breed-specific differences in growth performance and meat production.
Cai Shufang +12 more
doaj +1 more source
Journal of Animal Science and Biotechnology, 2022 Background Cytosolic Ca2+ plays vital roles in myogenesis and muscle development. As a major Ca2+ release channel of endoplasmic reticulum (ER), ryanodine receptor 1 (RyR1) key mutations are main causes of severe congenital myopathies.
Kai Qiu +7 more
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Kindlin 2 regulates myogenic related factor myogenin via a canonical Wnt signaling in myogenic differentiation. [PDF]
PLoS ONE, 2013 Kindlin 2, as an integrin-associated protein, is required for myocyte elongation and fusion. However, the association of Kindlin 2 with muscle differentiation-related signaling pathways is unknown. Here, we identified a mechanism that Kindlin 2 regulates
Yu Yu +5 more
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Apol9a regulates myogenic differentiation via the ERK1/2 pathway in C2C12 cells
Frontiers in Pharmacology, 2022 Background: The rising prevalence of obesity and its complications is a big challenge for the global public health. Obesity is accompanied by biological dysfunction of skeletal muscle and the development of muscle atrophy.
Xuan Jiang +11 more
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Cells, 2022 Myostatin (MSTN) is a negative regulator of skeletal muscle development and plays an important role in muscle development. Fluctuations in gene expression influenced by DNA methylation are critical for homeostatic responses in muscle.
Yiping Zhao +8 more
doaj +1 more source