Reprogrammed lipid metabolism protects inner nuclear membrane against unsaturated fat
Developmental Cell, 2021 Summary The cell nucleus is surrounded by a double membrane. The lipid packing and viscosity of membranes is critical for their function and is tightly controlled by lipid saturation. Circuits regulating the lipid saturation of the outer nuclear membrane
Alwin Kohler
exaly +3 more sources
Regulation of inner nuclear membrane associated protein degradation [PDF]
Nucleus, 2019 The nucleus is enclosed by a double-membrane structure, the nuclear envelope, which separates the nucleoplasm from the cytoplasm. The outer nuclear membrane is continuous with the endoplasmic reticulum (ER), whereas the inner nuclear membrane (INM) is a ...
Bailey Koch, Hong-Guo Yu
doaj +3 more sources
Targeting of LRRC59 to the Endoplasmic Reticulum and the Inner Nuclear Membrane [PDF]
International Journal of Molecular Sciences, 2019 LRRC59 (leucine-rich repeat-containing protein 59) is a tail-anchored protein with a single transmembrane domain close to its C-terminal end that localizes to the endoplasmic reticulum (ER) and the nuclear envelope. Here, we investigate the mechanisms of
Ralph Kehlenbach
exaly +3 more sources
Developmental Cell, 2019 Summary Cells dynamically adjust organelle organization in response to growth and environmental cues. This requires regulation of synthesis of phospholipids, the building blocks of organelle membranes, or remodeling of their fatty-acyl (FA) composition ...
Symeon Siniossoglou +2 more
exaly +3 more sources
Diacylglycerol at the inner nuclear membrane fuels nuclear envelope expansion in closed mitosis [PDF]
J Cell Sci, 2022 Nuclear envelope (NE) expansion must be controlled to maintain nuclear shape and function. The nuclear membrane expands massively during ‘closed’ mitosis, enabling chromosome segregation within an intact NE. Phosphatidic acid (PA) and diacylglycerol (DG)
Sherman Foo +3 more
semanticscholar +3 more sources
Regulated degradation of the inner nuclear membrane protein SUN2 maintains nuclear envelope architecture and function [PDF]
Elife, 2022 Nuclear architecture and functions depend on dynamic interactions between nuclear components (such as chromatin) and inner nuclear membrane (INM) proteins. Mutations in INM proteins interfering with these interactions result in disease.
L. Krshnan +6 more
semanticscholar +3 more sources
SUMOylation at the inner nuclear membrane facilitates nuclear envelope biogenesis during mitosis [PDF]
J Cell Biol, 2023 Saik et al. show that multiple yeast inner nuclear membrane (INM) proteins are SUMOylated during mitosis. These INM-specific SUMOylation events support mitotic nuclear membrane expansion by increasing INM phosphatidic acid levels, temporally coupling ...
Natasha O Saik +5 more
semanticscholar +2 more sources
Norepinephrine activates β1-adrenergic receptors at the inner nuclear membrane in astrocytes [PDF]
Glia, 2022 Norepinephrine exerts powerful influences on the metabolic, neuroprotective and immunoregulatory functions of astrocytes. Until recently, all effects of norepinephrine were believed to be mediated by receptors localized exclusively to the plasma membrane.
K. C. Benton +15 more
semanticscholar +2 more sources
The role of inner nuclear membrane proteins in tumourigenesis and as potential targets for cancer therapy [PDF]
Cancer Metastasis Rev, 2022 Despite significant advances in our understanding of tumourigenesis and cancer therapeutics, cancer continues to account for 30% of worldwide deaths.
M. Rose +4 more
semanticscholar +2 more sources
The Diverse Cellular Functions of Inner Nuclear Membrane Proteins. [PDF]
Cold Spring Harb Perspect Biol, 2021 The nuclear compartment is delimited by a specialized expanded sheet of the endoplasmic reticulum (ER) known as the nuclear envelope (NE). Compared to the outer nuclear membrane and the contiguous peripheral ER, the inner nuclear membrane (INM) houses a ...
Sumit Pawar, U. Kutay
semanticscholar +2 more sources