Regulation of inner nuclear membrane associated protein degradation [PDF]
Nucleus, 2019 The nucleus is enclosed by a double-membrane structure, the nuclear envelope, which separates the nucleoplasm from the cytoplasm. The outer nuclear membrane is continuous with the endoplasmic reticulum (ER), whereas the inner nuclear membrane (INM) is a ...
Bailey Koch, Hong-Guo Yu
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Functional K(v)10.1 channels localize to the inner nuclear membrane. [PDF]
PLoS ONE, 2011 Ectopically expressed human K(V)10.1 channels are relevant players in tumor biology. However, their function as ion channels at the plasma membrane does not totally explain their crucial role in tumors.
Ye Chen +5 more
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Seipin governs phosphatidic acid homeostasis at the inner nuclear membrane [PDF]
Nature CommunicationsThe nuclear envelope is a specialized subdomain of the endoplasmic reticulum and comprises the inner and outer nuclear membranes. Despite the crucial role of the inner nuclear membrane in genome regulation, its lipid metabolism remains poorly understood.
Anete Romanauska +3 more
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Rice small protein OsS1Fa1 participates in stress responses as an inner nuclear membrane protein [PDF]
Plant Signaling & BehaviorThe rice small protein OsS1Fa1, a homolog of spinach S1Fa, plays a significant role in drought tolerance, attributed to its transmembrane domain. In this study, we aim to further elucidate the potential roles of OsS1Fa1 in cold and biotic stresses as an ...
Wang Ki Min +3 more
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A distinct inner nuclear membrane proteome in Saccharomyces cerevisiae gametes [PDF]
G3: Genes, Genomes, Genetics, 2021 The inner nuclear membrane (INM) proteome regulates gene expression, chromatin organization, and nuclear transport; however, it is poorly understood how changes in INM protein composition contribute to developmentally regulated processes, such as ...
Shary N Shelton +3 more
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Regulated degradation of the inner nuclear membrane protein SUN2 maintains nuclear envelope architecture and function [PDF]
eLife, 2022 Nuclear architecture and functions depend on dynamic interactions between nuclear components (such as chromatin) and inner nuclear membrane (INM) proteins. Mutations in INM proteins interfering with these interactions result in disease.
Logesvaran Krshnan +6 more
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The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts. [PDF]
PLoS Biology, 2022 Nuclear envelope membrane proteins (NEMPs) are a conserved family of nuclear envelope (NE) proteins that reside within the inner nuclear membrane (INM). Even though Nemp1 knockout (KO) mice are overtly normal, they display a pronounced splenomegaly. This
Didier Hodzic +8 more
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C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin [PDF]
eLifeThe inner nuclear membrane (INM), a subdomain of the endoplasmic reticulum (ER), sequesters hundreds of transmembrane proteins within the nucleus. We previously found that one INM protein, emerin, can evade the INM by secretory transport to the lysosome,
Jessica Mella +3 more
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Nuclear pore assembly proceeds by an inside-out extrusion of the nuclear envelope [PDF]
eLife, 2016 The nuclear pore complex (NPC) mediates nucleocytoplasmic transport through the nuclear envelope. How the NPC assembles into this double membrane boundary has remained enigmatic.
Shotaro Otsuka +8 more
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Frontiers in Cell and Developmental Biology, 2022 Invaginations of the nuclear membrane occur in different shapes, sizes, and compositions. Part of these pleiomorphic invaginations make up the nucleoplasmic reticulum (NR), while others are merely nuclear folds.
Merel Stiekema +16 more
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