Results 31 to 40 of about 3,326,595 (262)

The HSV1 Tail-Anchored Membrane Protein pUL34 Contains a Basic Motif That Supports Active Transport to the Inner Nuclear Membrane Prior to Formation of the Nuclear Egress Complex [PDF]

Viruses, 2021
Susanne Bailer, Christina Funk
exaly   +2 more sources

Targeting and Insertion of Membrane Proteins in Mitochondria

Frontiers in Cell and Developmental Biology, 2021
Mitochondrial membrane proteins play an essential role in all major mitochondrial functions. The respiratory complexes of the inner membrane are key for the generation of energy. The carrier proteins for the influx/efflux of essential metabolites to/from
Ross Eaglesfield, Kostas Tokatlidis
doaj   +1 more source

Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore [PDF]

, 2004
Resident integral proteins of the inner nuclear membrane (INM) are synthesized as membrane-integrated proteins on the peripheral endoplasmic reticulum (ER) and are transported to the INM throughout interphase using an unknown trafficking mechanism.
Gerace, Larry, Nishimoto, Takeharu, Schirmer, Eric C, Eric C. Schirmer, Ohba, Tomoyuki, Tomoyuki Ohba, Takeharu Nishimoto, Larry Gerace   +7 more
core   +1 more source

Involvement of the lamin rod domain in heterotypic lamin interactions important for nuclear organization [PDF]

, 2001
The nuclear lamina is a meshwork of intermediate-type filament proteins (lamins) that lines the inner nuclear membrane. The lamina is proposed to be an important determinant of nuclear structure, but there has been little direct testing of this idea.
Tinglu Guan, Gerace, L, Eric C. Schirmer, Schirmer, Eric, Guan, T, Larry Gerace   +5 more
core   +1 more source

The nuclear lamina is a hub for the nuclear function of Jacob

Molecular Brain, 2021
Jacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of Jacob and report a prominent targeting to the nuclear envelope that requires NMDAR ...
Sebastian Samer, Rajeev Raman, Gregor Laube, Michael R. Kreutz, Anna Karpova   +4 more
doaj   +1 more source

The LEM-ESCRT toolkit: Repair and maintenance of the nucleus

Frontiers in Cell and Developmental Biology, 2022
The eukaryotic genome is enclosed in a nuclear envelope that protects it from potentially damaging cellular activities and physically segregates transcription and translation.Transport across the NE is highly regulated and occurs primarily via the ...
Sapan Borah, Karthigeyan Dhanasekaran, Santosh Kumar   +2 more
doaj   +1 more source

Genetic architecture of band neutrophil fraction in Iceland

Communications Biology, 2022
A GWAS in Iceland reveals that variants in inner nuclear membrane proteins are associated with nuclear morphology of granulocytes and band neutrophil fraction.
Gudjon R. Oskarsson, Magnus K. Magnusson, Asmundur Oddsson, Brynjar O. Jensson, Run Fridriksdottir, Gudny A. Arnadottir, Hildigunnur Katrinardottir, Solvi Rognvaldsson, Gisli H. Halldorsson, Gardar Sveinbjornsson, Erna V. Ivarsdottir, Lilja Stefansdottir, Egil Ferkingstad, Kristjan Norland, Vinicius Tragante, Jona Saemundsdottir, Aslaug Jonasdottir, Adalbjorg Jonasdottir, Svanhvit Sigurjonsdottir, Karen O. Petursdottir, Olafur B. Davidsson, Thorunn Rafnar, Hilma Holm, Isleifur Olafsson, Pall T. Onundarson, Brynjar Vidarsson, Olof Sigurdardottir, Gisli Masson, Daniel F. Gudbjartsson, Ingileif Jonsdottir, Gudmundur L. Norddahl, Unnur Thorsteinsdottir, Patrick Sulem, Kari Stefansson   +33 more
doaj   +1 more source

The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations

eLife, 2016
Lamin B receptor (LBR) is a polytopic membrane protein residing in the inner nuclear membrane in association with the nuclear lamina. We demonstrate that human LBR is essential for cholesterol synthesis.
Pei-Ling Tsai, Chenguang Zhao, Elizabeth Turner, Christian Schlieker   +3 more
doaj   +1 more source

NDC1 : a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes [PDF]

, 2006
POM121 and gp210 were, until this point, the only known membrane-integral nucleoporins (Nups) of vertebrates and, thus, the only candidate anchors for nuclear pore complexes (NPCs) within the nuclear membrane. In an accompanying study (Stavru et al.), we
Gorlich, D., Hülsmann, Bastian, Anne Spang, Cordes, V., Stavru, F., Hartmann, E., Dirk Görlich, Spang, Anne, Cordes, Volker, C., Volker C. Cordes, Hülsmann, B., Hulsmann, B. B., Bastian B. Hülsmann, Cordes, V. C., Hartmann, Enno, Fabrizia Stavru, Görlich, Dirk, Stavru, Fabrizia, Enno Hartmann, Spang, A., Cordes, Volker,   +20 more
core   +1 more source

Nuclear lipids: key signaling effectors in the nervous system and other tissues1

Journal of Lipid Research, 2004
Lipids have long been recognized as quantitatively minor components of the nucleus, where they were initially thought to have little functional importance; but they now command growing interest, with recognition of their diverse signaling and modulating ...
Robert W. Ledeen, Gusheng Wu
doaj   +1 more source