Results 51 to 60 of about 3,326,595 (262)

PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress

Developmental Cell, 2018
Summary Cell and organelle membranes consist of a complex mixture of phospholipids (PLs) that determine their size, shape, and function. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic membranes, yet how cells sense and regulate ...
Afreen Haider, Yu-Chen Wei, Koini Lim, Antonio D. Barbosa, Che-Hsiung Liu, U. Weber, M. Mlodzik, Kadri Oras, Simon Collier, M. Hussain, Liang Dong, Satish Patel, Anna Alvarez-Guaita, V. Saudek, Ben Jenkins, A. Koulman, Marcus K. Dymond, R. Hardie, S. Siniossoglou, D. Savage   +19 more
semanticscholar   +1 more source

Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope [PDF]

, 2002
Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation.
Gerace, Larry, Schirmer, Eric C
core   +1 more source

Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress

bioRxiv, 2019
The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum (ER) that is gated by the nuclear pore complex. It is unknown whether proteins of the INM and ER are degraded through shared or distinct pathways in mammalian cells.
A. Buchwalter, R. Schulte, Hsiao H. Tsai, Juliana S. Capitanio, M. Hetzer   +4 more
semanticscholar   +1 more source

Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane

Nature Communications, 2019
Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) repair pathway choice from yeast to human. The molecular mechanisms that enable Rif1 to fulfill its diverse roles remain to be determined.
Gabriele A. Fontana, D. Hess, J. Reinert, Stefano Mattarocci, B. Falquet, D. Klein, D. Shore, N. Thomä, Ulrich Rass   +8 more
semanticscholar   +1 more source

Translocation and insertion of precursor proteins into isolated outer membranes of mitochondria [PDF]

, 1993
Nuclear-encoded proteins destined for mitochondria must cross the outer or both outer and inner membranes to reach their final sub- mitochondrial locations. While the inner membrane can translocate preproteins by itself, it is not known whether the outer
W Neupert, Lill, Roland, Neupert, Walter, A Mayer, Mayer, Andreas, R Lill   +5 more
core   +2 more sources

Protocol for single-molecule fluorescence recovery after photobleaching microscopy to analyze the dynamics and spatial locations of nuclear transmembrane proteins in live cells

STAR Protocols, 2021
Summary: Single-molecule fluorescence recovery after photobleaching (smFRAP) is a newly developed technique that combines single-molecule super-resolution microscopy and traditional FRAP microscopy.
Mark Tingey, Yichen Li, Weidong Yang
doaj   +1 more source

Proteomic mapping by rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane

Journal of Biological Chemistry, 2019
Vesicle-associated membrane protein–associated protein B (VAPB) is a tail-anchored protein that is present at several contact sites of the endoplasmic reticulum (ER).
C. James, Marret Müller, M. Goldberg, C. Lenz, H. Urlaub, R. Kehlenbach   +5 more
semanticscholar   +1 more source

Discovery and restoration of Aberrant Nuclear structure and Genome behaviour in breast cancer cells [PDF]

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The eukaryotic interphase nucleus is well organised and the genome positioned non-randomly.
Hassan Ahmed, Mai
core   +7 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores

Nature Communications, 2020
The contribution of central and peripheral channels of nuclear pores to transport of transmembrane proteins is unclear. Here the authors show that most inner nuclear membrane proteins use only peripheral channels, but some extend nuclear localization ...
Krishna C. Mudumbi, Rafal Czapiewski, Andrew Ruba, Samuel L. Junod, Yichen Li, Wangxi Luo, Christina Ngo, Valentina Ospina, Eric C. Schirmer, Weidong Yang   +9 more
doaj   +1 more source