Results 41 to 50 of about 315,665 (286)

Transport into mitochondria and intramitochondrial sorting of the Fe/S protein of ubiquinol-cytochrome c reductase [PDF]

, 1986
The Fe/S protein of complex III is encoded by a nuclear gene, synthesized in the cytoplasm as a precursor with a 32 residue amino-terminal extension, and transported to the outer surface of the inner mitochondrial membrane. Our data suggest the following
Beinert, Bell, Bradford, Böhni, Conboy, Daum, Dowhan, Dumont, Edwards, Fujiki, Gabellini, Gabellini, Gasser, Gasser, Guiard, Hallermayer, Harmey, Harnisch, Hauska, Hay, Hennig, Hennig, Horwich, Horwich, Hurt, Hurt, Hurt, Kaput, Karlsson, Kolansky, Korb, Laemmli, Lewin, Li, Li, McAda, Miura, Ohashi, Pelham, Pfanner, Ploegh, Rieske, Sadler, Schatz, Schleyer, Schleyer, Schmidt, Schmidt, Schnaitman, Sidhu, Taniuchi, Teintze, Tomita, Trumpower, van Loon, van Loon, von Jagow, Wachter, Zimmermann, Zwizinski, Zwizinski   +60 more
core   +1 more source

Early sorting of inner nuclear membrane proteins is conserved [PDF]

Proceedings of the National Academy of Sciences, 2007
Spodoptera frugiperda (Sf9) importin-α-16 is a translocon-associated protein that participates in the early sorting pathway of baculovirus integral membrane proteins destined for the inner nuclear membrane (INM). To discern whether sorting intermediate protein complexes like those observed in insect cells are also formed with ...
Sharon C, Braunagel, Shawn T, Williamson, Qi, Ding, Xiaogiang, Wu, Max D, Summers   +4 more
openaire   +2 more sources

Active Nuclear Import of Membrane Proteins Revisited

Cells, 2015
It is poorly understood how membrane proteins destined for the inner nuclear membrane pass the crowded environment of the Nuclear Pore Complex (NPC). For the Saccharomyces cerevisiae proteins Src1/Heh1 and Heh2, a transport mechanism was proposed where ...
Justyna K. Laba, Anton Steen, Petra Popken, Alina Chernova, Bert Poolman, Liesbeth M. Veenhoff   +5 more
doaj   +1 more source

A dynamic model of the mitochondrial protein import machinery [PDF]

, 1992
Many proteins are translocated into or across two mem-branes in order to reach their functional destination; these include many nuclear-encoded mitochondrial and chloro-plast proteins, as well as proteins transported into or across the outer membrane of ...
Baker, Bayer, Brdiczka, Filloux, Glick, Hackenbrock, Hartl, Hwang, Hwang, Kellems, Kiebler, Koronakis, Lill, Martin, Pfanner, Pugsley, Rassow, Rassow, Schleyer, Schwaiger, Sen, Söllner, Söllner, Van Venetie, Vestweber   +24 more
core   +3 more sources

MICROTUBULATION OF THE INNER MEMBRANE OF THE NUCLEAR ENVELOPE [PDF]

The Journal of Cell Biology, 1961
In the course of a light and electron microscopy study of spermatogenesis in the European crayfish, Astacus fluviatilis, spermatocytes of abnormal appearance were observed in two instances in individuals that had passed the mating period. The electron microscope showed that the inner membrane of the nuclear envelope of these cells was erupting into a ...
G A, MEEK, M J, MOSES
openaire   +2 more sources

Nuclear membrane protein Lem2 regulates nuclear size through membrane flow

Nature Communications, 2019
Nuclear size scales with cell size, but the underlying mechanisms are unclear. Here, the authors report in fission yeast that the inner nuclear membrane protein Lem2 and the ER membrane protein Lnp1 are barriers to membrane flow and propose that they ...
Kazunori Kume, Helena Cantwell, Alana Burrell, Paul Nurse   +3 more
doaj   +1 more source

Structural Basis for Capsid Recruitment and Coat Formation during HSV-1 Nuclear Egress

Proceedings, 2020
During herpesvirus infection, nascent viral capsids egress the nucleus into the cytoplasm by an unusual mechanism whereby capsids bud at the inner nuclear membrane.
Elizabeth Draganova, Jiayan Zhang, Hong Zhou, Ekaterina Heldwein   +3 more
doaj   +1 more source

Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane [PDF]

, 2019
Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) repair pathway choice from yeast to human. The molecular mechanisms that enable Rif1 to fulfill its diverse roles remain to be determined.
A Davé, A Kalousi, A Seeber, A Taddei, AF Roth, B Chen, B MacLean, BR Martin, C Escribano-Diaz, C Horigome, C Lemaître, C Zierhut, CA Fox, CA Schneider, D Cornacchia, DE Gottschling, G Kyrion, G Xu, GA Fontana, H Dev, H Ghezraoui, H Zhang, J Schindelin, J Tomida, J Wan, JA Vizcaíno, JE DiCarlo, JK Moore, JM Peace, JR Chapman, K Bystricky, K Moriyama, KKY Lam, L Feng, L Hafner, L Hafner, LH Chamberlain, M Blanc, M Deng, M Di Virgilio, M Hayano, M Kalocsay, M Zimmermann, MD Resh, MS Longtine, N Cao, P Oza, R Foti, R Gupta, R Kumar, RC Alver, S Mattarocci, S Mattarocci, S Mattarocci, S Nagai, S Park, S Stuckey, S Yamazaki, SE Lee, SI Hiraga, SM Noordermeer, T Lanyon-Hogg, T Shi, U Rass, V Boersma, Y Ji, Y Kanoh, Y Ohno, Y Zhang, Z Mirman   +69 more
core   +1 more source

Herpes Simplex Virus 1 Us3 Deletion Mutant is Infective Despite Impaired Capsid Translocation to the Cytoplasm

Viruses, 2015
Herpes simplex virus 1 (HSV-1) capsids are assembled in the nucleus bud at the inner nuclear membrane into the perinuclear space, acquiring envelope and tegument. In theory, these virions are de-enveloped by fusion of the envelope with the outer nuclear
Peter Wild, Sabine Leisinger, Anna Paula de Oliveira, Elisabeth M. Schraner, Andres Kaech, Mathias Ackermann, Kurt Tobler   +6 more
doaj   +1 more source

Generating Membrane Curvature at the Nuclear Pore: A Lipid Point of View

Cells, 2022
In addition to its structural role in enclosing and protecting the genome, the nuclear envelope (NE) forms a highly adaptive communication interface between the cytoplasm and the nuclear interior in eukaryotic cells.
Bas W. A. Peeters, Alexandra C. A. Piët, Maarten Fornerod   +2 more
doaj   +1 more source