Results 41 to 50 of about 3,326,595 (262)

Active Nuclear Import of Membrane Proteins Revisited

Cells, 2015
It is poorly understood how membrane proteins destined for the inner nuclear membrane pass the crowded environment of the Nuclear Pore Complex (NPC). For the Saccharomyces cerevisiae proteins Src1/Heh1 and Heh2, a transport mechanism was proposed where ...
Justyna K. Laba, Anton Steen, Petra Popken, Alina Chernova, Bert Poolman, Liesbeth M. Veenhoff   +5 more
doaj   +1 more source

Structural Basis for Capsid Recruitment and Coat Formation during HSV-1 Nuclear Egress

Proceedings, 2020
During herpesvirus infection, nascent viral capsids egress the nucleus into the cytoplasm by an unusual mechanism whereby capsids bud at the inner nuclear membrane.
Elizabeth Draganova, Jiayan Zhang, Hong Zhou, Ekaterina Heldwein   +3 more
doaj   +1 more source

Herpes Simplex Virus 1 Us3 Deletion Mutant is Infective Despite Impaired Capsid Translocation to the Cytoplasm

Viruses, 2015
Herpes simplex virus 1 (HSV-1) capsids are assembled in the nucleus bud at the inner nuclear membrane into the perinuclear space, acquiring envelope and tegument. In theory, these virions are de-enveloped by fusion of the envelope with the outer nuclear
Peter Wild, Sabine Leisinger, Anna Paula de Oliveira, Elisabeth M. Schraner, Andres Kaech, Mathias Ackermann, Kurt Tobler   +6 more
doaj   +1 more source

Generating Membrane Curvature at the Nuclear Pore: A Lipid Point of View

Cells, 2022
In addition to its structural role in enclosing and protecting the genome, the nuclear envelope (NE) forms a highly adaptive communication interface between the cytoplasm and the nuclear interior in eukaryotic cells.
Bas W. A. Peeters, Alexandra C. A. Piët, Maarten Fornerod   +2 more
doaj   +1 more source

Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery [PDF]

, 2013
BACKGROUND: Different cell types have distinctive patterns of chromosome positioning in the nucleus. Although ectopic affinity-tethering of specific loci can be used to relocate chromosomes to the nuclear periphery, endogenous nuclear envelope proteins ...
Vassiliki Lazou, Harrison, David J, Schirmer, Eric C, David J Harrison, Zuleger, Nikolaj, de Las Heras, Jose I, Wendy A Bickmore, Dzmitry G Batrakou, Lazou, Vassiliki, Batrakou, Dzmitry G, Jose I de las Heras, Bickmore, Wendy A, Nikolaj Zuleger, Shelagh Boyle, Kelly, David A, Korfali, Nadia, Nadia Korfali, Glenn E Morris, Eric C Schirmer, Boyle, Shelagh, David A Kelly, K Natalie Randles, Randles, K Natalie, Morris, Glenn E   +23 more
core   +1 more source

Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.

PLoS Genetics, 2014
Recent interest has focused on the importance of the nucleus and associated nucleoskeleton in regulating changes in cardiac gene expression in response to biomechanical load.
Indroneal Banerjee, Jianlin Zhang, Thomas Moore-Morris, Emily Pfeiffer, Kyle S Buchholz, Ao Liu, Kunfu Ouyang, Matthew J Stroud, Larry Gerace, Sylvia M Evans, Andrew McCulloch, Ju Chen   +11 more
doaj   +1 more source

ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity

Nature Communications, 2018
Vesicle-mediated nucleocytoplasmic transport is a nuclear pore-independent mechanism for the nuclear export of macromolecular complexes, but the molecular basis for this transport remains largely unknown.
Jun Arii, Mizuki Watanabe, Fumio Maeda, N. Tokai‐Nishizumi, Takahiro Chihara, M. Miura, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Y. Kawaguchi   +9 more
semanticscholar   +1 more source

Anomalous diffusion induced by cristae geometry in the inner mitochondrial membrane [PDF]

, 2009
Diffusion of inner membrane proteins is a prerequisite for correct functionality of mitochondria. The complicated structure of tubular, vesicular or flat cristae and their small connections to the inner boundary membrane impose constraints on the ...
Jürgen Bereiter-Hahn, Sukhorukov Valerii M., Sukhorukov, Valerii M., Valerii M Sukhorukov, Bereiter-Hahn Jürgen, Bereiter-Hahn, Jürgen, Valerii M. Sukhorukov   +6 more
core   +2 more sources

Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane.

PLoS Biology, 2004
X-linked Emery-Dreifuss muscular dystrophy is caused by loss of emerin, a LEM-domain protein of the nuclear inner membrane. To better understand emerin function, we used affinity chromatography to purify emerin-binding proteins from nuclear extracts of ...
James M Holaska, Amy K Kowalski, Katherine L Wilson   +2 more
doaj   +1 more source

The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis. [PDF]

PLoS Genetics, 2011
The budding yeast spindle pole body (SPB) is anchored in the nuclear envelope so that it can simultaneously nucleate both nuclear and cytoplasmic microtubules. During SPB duplication, the newly formed SPB is inserted into the nuclear membrane.
Jennifer M Friederichs, Suman Ghosh, Christine J Smoyer, Scott McCroskey, Brandon D Miller, Kyle J Weaver, Kym M Delventhal, Jay Unruh, Brian D Slaughter, Sue L Jaspersen   +9 more
doaj   +1 more source