Results 21 to 30 of about 158,042 (243)
Nuclear envelope proteomics: Novel integral membrane proteins of the inner nuclear membrane [PDF]
Proceedings of the National Academy of Sciences, 2001 The nuclear envelope (NE) is one of the least characterized structures of eukaryotic cells. The study of its functional roles is hampered by the small number of proteins known to be specifically located to it. Here, we present a comprehensive characterization of the NE proteome.
M, Dreger +4 more
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Genetic architecture of band neutrophil fraction in Iceland
Communications Biology, 2022 A GWAS in Iceland reveals that variants in inner nuclear membrane proteins are associated with nuclear morphology of granulocytes and band neutrophil fraction.
Gudjon R. Oskarsson +33 more
doaj +1 more source
The LEM-ESCRT toolkit: Repair and maintenance of the nucleus
Frontiers in Cell and Developmental Biology, 2022 The eukaryotic genome is enclosed in a nuclear envelope that protects it from potentially damaging cellular activities and physically segregates transcription and translation.Transport across the NE is highly regulated and occurs primarily via the ...
Sapan Borah +2 more
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eLife, 2016 Lamin B receptor (LBR) is a polytopic membrane protein residing in the inner nuclear membrane in association with the nuclear lamina. We demonstrate that human LBR is essential for cholesterol synthesis.
Pei-Ling Tsai +3 more
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Nuclear lipids: key signaling effectors in the nervous system and other tissues1
Journal of Lipid Research, 2004 Lipids have long been recognized as quantitatively minor components of the nucleus, where they were initially thought to have little functional importance; but they now command growing interest, with recognition of their diverse signaling and modulating ...
Robert W. Ledeen, Gusheng Wu
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eLife, 2017 Newly synthesized membrane proteins are targeted to the inner nuclear membrane (INM) by diffusion within the membrane system of the endoplasmic reticulum (ER), translocation through nuclear pore complexes (NPCs) and retention on nuclear partners. Using a
Sumit Pawar +4 more
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Active Nuclear Import of Membrane Proteins Revisited
Cells, 2015 It is poorly understood how membrane proteins destined for the inner nuclear membrane pass the crowded environment of the Nuclear Pore Complex (NPC). For the Saccharomyces cerevisiae proteins Src1/Heh1 and Heh2, a transport mechanism was proposed where ...
Justyna K. Laba +5 more
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Nuclear membrane protein Lem2 regulates nuclear size through membrane flow
Nature Communications, 2019 Nuclear size scales with cell size, but the underlying mechanisms are unclear. Here, the authors report in fission yeast that the inner nuclear membrane protein Lem2 and the ER membrane protein Lnp1 are barriers to membrane flow and propose that they ...
Kazunori Kume +3 more
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Patrolling the nucleus: inner nuclear membrane-associated degradation. [PDF]
Curr Genet, 2019 Protein quality control and transport are important for the integrity of organelles such as the endoplasmic reticulum, but it is largely unknown how protein homeostasis is regulated at the nuclear envelope (NE) despite the connection between NE protein function and human disease.
Smoyer CJ, Jaspersen SL.
europepmc +4 more sources
Getting to and through the inner nuclear membrane during herpesvirus nuclear egress [PDF]
Current Opinion in Cell Biology, 2017 Herpesviruses, like most DNA viruses, replicate and package their genomes into capsids in the host cell nucleus. Capsids then transit to the cytoplasm in a fascinating process called nuclear egress, which includes several unusual steps: Movement of capsids from the nuclear interior to the periphery, disruption of the nuclear lamina, capsid budding ...
Ming F, Lye +4 more
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