Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants [PDF]
Nat Commun, 2020 The inner nuclear membrane (INM) selectively accumulates proteins that are essential for nuclear functions; however, overaccumulation of INM proteins results in a range of rare genetic disorders. So far, little is known about how defective, mislocalized,
Aobo Huang +7 more
semanticscholar +2 more sources
A distinct inner nuclear membrane proteome in Saccharomyces cerevisiae gametes [PDF]
G3: Genes, Genomes, Genetics, 2021 The inner nuclear membrane (INM) proteome regulates gene expression, chromatin organization, and nuclear transport; however, it is poorly understood how changes in INM protein composition contribute to developmentally regulated processes, such as ...
Shary N Shelton +3 more
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The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts. [PDF]
PLoS Biology, 2022 Nuclear envelope membrane proteins (NEMPs) are a conserved family of nuclear envelope (NE) proteins that reside within the inner nuclear membrane (INM). Even though Nemp1 knockout (KO) mice are overtly normal, they display a pronounced splenomegaly. This
Didier Hodzic +8 more
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Patrolling the nucleus: inner nuclear membrane-associated degradation [PDF]
Curr Genet, 2019 Protein quality control and transport are important for the integrity of organelles such as the endoplasmic reticulum, but it is largely unknown how protein homeostasis is regulated at the nuclear envelope (NE) despite the connection between NE protein ...
Christine J. Smoyer, Sue L. Jaspersen
semanticscholar +2 more sources
C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin [PDF]
eLifeThe inner nuclear membrane (INM), a subdomain of the endoplasmic reticulum (ER), sequesters hundreds of transmembrane proteins within the nucleus. We previously found that one INM protein, emerin, can evade the INM by secretory transport to the lysosome,
Jessica Mella +3 more
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Cell Reports, 2015 Although nucleo-cytoplasmic transport is typically mediated through nuclear pore complexes, herpesvirus capsids exit the nucleus via a unique vesicular pathway.
Tzviya Zeev-Ben-Mordehai +15 more
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Protein quality control at the inner nuclear membrane
Nature, 2014 The nuclear envelope is a double membrane that separates the nucleus from the cytoplasm. The inner nuclear membrane (INM) functions in essential nuclear processes including chromatin organization and regulation of gene expression.
Marina Pantazopoulou +2 more
exaly +2 more sources
Weaving a pattern from disparate threads: lamin function in nuclear assembly and DNA replication [PDF]
, 1994 The major residual structure that remains associated with the nuclear envelope following extraction of isolated nuclei or oocyte germinal vesicles with non-ionic detergents, nucleases and high salt is the lamina (Fawcett, 1966; Aaronson and Blobel ...
Hutchison, CJ +3 more
core +6 more sources
Both emerin and lamin C depend on lamin A for localization at the nuclear envelope [PDF]
, 2001 Physical interactions between lamins and emerin were investigated by co-immunoprecipitation of in vitro translated proteins. Emerin interacted with in vitro translated lamins A, B1 and C in co-immunprecipitation reactions.
Whitfield, WGF +8 more
core +8 more sources
Frontiers in Cell and Developmental Biology, 2022 Invaginations of the nuclear membrane occur in different shapes, sizes, and compositions. Part of these pleiomorphic invaginations make up the nucleoplasmic reticulum (NR), while others are merely nuclear folds.
Merel Stiekema +16 more
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