Results 21 to 30 of about 315,665 (286)
Targeting and Insertion of Membrane Proteins in Mitochondria
Frontiers in Cell and Developmental Biology, 2021 Mitochondrial membrane proteins play an essential role in all major mitochondrial functions. The respiratory complexes of the inner membrane are key for the generation of energy. The carrier proteins for the influx/efflux of essential metabolites to/from
Ross Eaglesfield, Kostas Tokatlidis
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Patrolling the nucleus: inner nuclear membrane-associated degradation. [PDF]
Curr Genet, 2019 Protein quality control and transport are important for the integrity of organelles such as the endoplasmic reticulum, but it is largely unknown how protein homeostasis is regulated at the nuclear envelope (NE) despite the connection between NE protein function and human disease.
Smoyer CJ, Jaspersen SL.
europepmc +4 more sources
The Inner Nuclear Membrane Takes On Lipid Metabolism [PDF]
Developmental Cell, 2018 Challenging the idea of the inner nuclear membrane (INM) being an inert compartment, recent work in S. cerevisiae shows that the INM can metabolize lipids and that local lipid metabolism can regulate transcription in response to lipid availability, suggesting a functional role for the INM in cellular lipid homeostasis.
Holly, Merta, Shirin, Bahmanyar
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The nuclear lamina is a hub for the nuclear function of Jacob
Molecular Brain, 2021 Jacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of Jacob and report a prominent targeting to the nuclear envelope that requires NMDAR ...
Sebastian Samer +4 more
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A morphological view on mitochondrial protein targeting [PDF]
, 1994 Mitochondrial protein targeting includes both intramitochondrial sorting of proteins encoded by the organellar genome and import and subsequent sorting of nuclear encoded precursor proteins. Only a few proteins are encoded by the mitochondrial genome and
Ades +55 more
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The LEM-ESCRT toolkit: Repair and maintenance of the nucleus
Frontiers in Cell and Developmental Biology, 2022 The eukaryotic genome is enclosed in a nuclear envelope that protects it from potentially damaging cellular activities and physically segregates transcription and translation.Transport across the NE is highly regulated and occurs primarily via the ...
Sapan Borah +2 more
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The subnuclear localization of tRNA ligase in yeast [PDF]
, 1987 Yeast tRNA ligase is an enzyme required for tRNA splicing. A study by indirect immune fluorescence shows that this enzyme is localized in the cell nucleus. At higher resolution, studies using indirect immune electron microscopy show this nuclear location
Abelson, John, Clark, Michael W.
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Genetic architecture of band neutrophil fraction in Iceland
Communications Biology, 2022 A GWAS in Iceland reveals that variants in inner nuclear membrane proteins are associated with nuclear morphology of granulocytes and band neutrophil fraction.
Gudjon R. Oskarsson +33 more
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Biogenesis of mitochondrial c-type cytochromes [PDF]
, 1990 Cytochromesc andc 1 are essential components of the mitochondrial respiratory chain. In both cytochromes the heme group is covalently linked to the polypeptide chain via thioether bridges. The location of the two cytochromes is in the intermembrane space;
Gonzales, Daniel H., Neupert, Walter
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eLife, 2016 Lamin B receptor (LBR) is a polytopic membrane protein residing in the inner nuclear membrane in association with the nuclear lamina. We demonstrate that human LBR is essential for cholesterol synthesis.
Pei-Ling Tsai +3 more
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