Seipin governs phosphatidic acid homeostasis at the inner nuclear membrane [PDF]
Nature CommunicationsThe nuclear envelope is a specialized subdomain of the endoplasmic reticulum and comprises the inner and outer nuclear membranes. Despite the crucial role of the inner nuclear membrane in genome regulation, its lipid metabolism remains poorly understood.
Anete Romanauska +3 more
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The ESCRT machinery directs quality control over inner nuclear membrane architecture [PDF]
Cell Rep, 2022 SUMMARY The late-acting endosomal sorting complex required for transport (ESCRT) machinery has been implicated in facilitating the resealing of the nuclear envelope (NE) after mitosis, enabling compartmentalization of the genome away from the cytoplasm ...
Raakhee Shankar +4 more
semanticscholar +2 more sources
Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome [PDF]
J Cell Biol, 2021 Mechanisms that turnover components of the nucleus and inner nuclear membrane (INM) remain to be fully defined. We explore how components of the INM are selected by a cytosolic autophagy apparatus through a transmembrane nuclear envelope-localized cargo ...
Sunandini Chandra +6 more
semanticscholar +2 more sources
The Alkylating Agent Methyl Methanesulfonate Triggers Lipid Alterations at the Inner Nuclear Membrane That Are Independent from Its DNA-Damaging Ability [PDF]
Int J Mol Sci, 2021 In order to tackle the study of DNA repair pathways, the physical and chemical agents creating DNA damage, the genotoxins, are frequently employed. Despite their utility, their effects are rarely restricted to DNA, and therefore simultaneously harm other
Sara Ovejero +2 more
semanticscholar +2 more sources
Nuclear lipid droplets form in the inner nuclear membrane in a seipin-independent manner [PDF]
J Cell Biol, 2020 Sołtysik et al. show that the inner nuclear membrane of nonhepatocytes harbors triglyceride synthesis enzymes and generates nuclear lipid droplets (LDs).
Kamil Sołtysik +6 more
semanticscholar +2 more sources
Nuclear membrane protein Lem2 regulates nuclear size through membrane flow [PDF]
Nature Communications, 2019 Nuclear size scales with cell size, but the underlying mechanisms are unclear. Here, the authors report in fission yeast that the inner nuclear membrane protein Lem2 and the ER membrane protein Lnp1 are barriers to membrane flow and propose that they ...
Kazunori Kume +3 more
doaj +2 more sources
Rice small protein OsS1Fa1 participates in stress responses as an inner nuclear membrane protein [PDF]
Plant Signaling & BehaviorThe rice small protein OsS1Fa1, a homolog of spinach S1Fa, plays a significant role in drought tolerance, attributed to its transmembrane domain. In this study, we aim to further elucidate the potential roles of OsS1Fa1 in cold and biotic stresses as an ...
Wang Ki Min +3 more
doaj +2 more sources
eLife, 2017 Newly synthesized membrane proteins are targeted to the inner nuclear membrane (INM) by diffusion within the membrane system of the endoplasmic reticulum (ER), translocation through nuclear pore complexes (NPCs) and retention on nuclear partners. Using a
Sumit Pawar +4 more
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The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets
Cell, 2018 Summary The inner nuclear membrane (INM) encases the genome and is fused with the outer nuclear membrane (ONM) to form the nuclear envelope. The ONM is contiguous with the endoplasmic reticulum (ER), the main site of phospholipid synthesis.
Alwin Kohler
exaly +2 more sources
Functional K(v)10.1 channels localize to the inner nuclear membrane. [PDF]
PLoS ONE, 2011 Ectopically expressed human K(V)10.1 channels are relevant players in tumor biology. However, their function as ion channels at the plasma membrane does not totally explain their crucial role in tumors.
Ye Chen +5 more
doaj +3 more sources