Results 11 to 20 of about 158,042 (243)
Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization [PDF]
Developmental Cell, 2019 Cells dynamically adjust organelle organization in response to growth and environmental cues. This requires regulation of synthesis of phospholipids, the building blocks of organelle membranes, or remodeling of their fatty-acyl (FA) composition. FAs are also the main components of triacyglycerols (TGs), which enable energy storage in lipid droplets ...
Symeon Siniossoglou +2 more
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The Diverse Cellular Functions of Inner Nuclear Membrane Proteins. [PDF]
Cold Spring Harb Perspect Biol, 2021 The nuclear compartment is delimited by a specialized expanded sheet of the endoplasmic reticulum (ER) known as the nuclear envelope (NE). Compared to the outer nuclear membrane and the contiguous peripheral ER, the inner nuclear membrane (INM) houses a unique set of transmembrane proteins that serve a staggering range of functions.
Pawar S, Kutay U.
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The Inner Nuclear Membrane Has a Unique Lipid Signature. [PDF]
BioessaysABSTRACTAlthough the inner nuclear membrane (INM) is generally considered to be continuous with the outer nuclear membrane (ONM) and connected to the remaining endoplasmic reticulum (ER), it has been well recognized that it is functionally distinct, having a unique protein composition.
Niu Y, Balla T.
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MICROTUBULATION OF THE INNER MEMBRANE OF THE NUCLEAR ENVELOPE [PDF]
The Journal of Cell Biology, 1961 In the course of a light and electron microscopy study of spermatogenesis in the European crayfish, Astacus fluviatilis, spermatocytes of abnormal appearance were observed in two instances in individuals that had passed the mating period. The electron microscope showed that the inner membrane of the nuclear envelope of these cells was erupting into a ...
G A, MEEK, M J, MOSES
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Making and breaking the inner nuclear membrane proteome
Current Opinion in Cell Biology, 2022 The nuclear envelope (NE) is the defining feature of eukaryotic cells, separating the nucleus from the cytoplasm. It has a complex architecture consisting of two lipid bilayers that, despite being continuous between them and with the endoplasmic reticulum, have different protein compositions consistent with their distinct functions.
Hahn, Lilli, Carvalho, Pedro
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The role of inner nuclear membrane protein emerin in myogenesis. [PDF]
FASEB JAbstract Emerin, a ubiquitously expressed inner nuclear membrane protein, plays a central role in maintaining nuclear structure and genomic organization, and in regulating gene expression and cellular signaling pathways. These functions are critical for proper myogenic differentiation and are closely linked to the
Marano N, Holaska JM.
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The Inner Nuclear Membrane Takes On Lipid Metabolism [PDF]
Developmental Cell, 2018 Challenging the idea of the inner nuclear membrane (INM) being an inert compartment, recent work in S. cerevisiae shows that the INM can metabolize lipids and that local lipid metabolism can regulate transcription in response to lipid availability, suggesting a functional role for the INM in cellular lipid homeostasis.
Holly, Merta, Shirin, Bahmanyar
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Traffic to the inner membrane of the nuclear envelope
Current Opinion in Cell Biology, 2014 Past research has yielded valuable insight into the mechanisms that regulate the nuclear transport of soluble molecules like transcription factors and mRNA. Much less is known about the mechanisms responsible for the transportation of membrane proteins to the inner membrane of the nuclear envelope. The key question is: does the facilitated transport of
Laba, Justyna K +2 more
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Targeting and Insertion of Membrane Proteins in Mitochondria
Frontiers in Cell and Developmental Biology, 2021 Mitochondrial membrane proteins play an essential role in all major mitochondrial functions. The respiratory complexes of the inner membrane are key for the generation of energy. The carrier proteins for the influx/efflux of essential metabolites to/from
Ross Eaglesfield, Kostas Tokatlidis
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The nuclear lamina is a hub for the nuclear function of Jacob
Molecular Brain, 2021 Jacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of Jacob and report a prominent targeting to the nuclear envelope that requires NMDAR ...
Sebastian Samer +4 more
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