Results 11 to 20 of about 4,236 (177)

Emerin Phosphorylation During the Early Phase of the Oxidative Stress Response Influences Emerin–BAF Interaction and BAF Nuclear Localization [PDF]

Cells, 2020
Reactive Oxygen Species (ROS) are reactive molecules required for the maintenance of physiological functions. Oxidative stress arises when ROS production exceeds the cellular ability to eliminate such molecules.
Stefano Squarzoni, Cristina Capanni, Vittoria Cenni   +2 more
exaly   +7 more sources

Emerin Deficiency Drives MCF7 Cells to an Invasive Phenotype [PDF]

Scientific Reports
During metastasis, cancer cells traverse the vasculature by squeezing through very small gaps in the endothelium. Thus, nuclei in metastatic cancer cells must become more malleable to move through these gaps.
James M Holaska, Christal Rolling
exaly   +7 more sources

Emerin acts as a mechanosensor linking force transmission and disease [PDF]

Frontiers in Oncology
For cells to respond to mechanical and biochemical cues in their environment, signals from the extracellular environment must be transmitted across the plasma membrane and into the nucleus to create the correct physical, transcriptional, and biochemical ...
Emily Hansen, Emily Hansen, James M. Holaska, James M. Holaska   +3 more
doaj   +4 more sources

Emerin expression stratification across breast cancer subtypes [PDF]

Cancer Treatment and Research Communications
Nuclear dysmorphism is a critical indicator of tumor aggressiveness, influencing cancer cell invasion and metastasis. Emerin, an integral nuclear envelope protein involved in nuclear architecture, is important for maintaining nuclear integrity.
Thaysa Ghiarone, Emily Hansen, James M. Holaska   +2 more
doaj   +5 more sources

Elevation of the mechanically-sensitive protein emerin links nuclear mechanotransduction to tau-induced cytoskeletal remodeling in neurons [PDF]

Nucleus
Neurodegenerative tauopathies, including Alzheimer’s disease, are neuropathologically defined by pathological tau deposition. While tau drives neurotoxicity by disrupting cytoskeletal, nucleoskeletal, and genomic architecture, cellular mechanisms ...
Claira Sohn, Sammy Pardo, Dana Molleur, Satvik R. Paduri, Morgan Lambert, Zachary Uttke, Erich J. Sohn, Morgan G. Thomas, Susan T. Weintraub, Bess Frost   +9 more
doaj   +2 more sources

Emerin Interacts With Histone Methyltransferases to Regulate Repressive Chromatin at the Nuclear Periphery

Frontiers in Cell and Developmental Biology, 2022
X-Linked Emery-Dreifuss muscular dystrophy is caused by mutations in the gene encoding emerin. Emerin is an inner nuclear membrane protein important for repressive chromatin organization at the nuclear periphery.
James M Holaska
exaly   +3 more sources

Emerin expression in tubular aggregates

Acta Neuropathologica, 2004
Emerin is an inner nuclear membrane protein that is mutated or not expressed in patients with X-linked Emery-Dreifuss muscular dystrophy (X-EDMD/EMD). Cytoplasmic localization of emerin in cultured cells or tissues has been reported, although this remains a controversial issue. Tubular aggregates (TAs) are pathological structures seen in the sarcoplasm
Manta, P., Terzis, G., Papadimitriou, C., Kontou, C., Vassilopoulos, D.   +4 more
core   +5 more sources

Emerin increase in regenerating muscle fibers

European Journal of Histochemistry, 2009
The fate of emerin during skeletal muscle regeneration was investigated in an animal model by means of crush injury. Immunofluorescence, immunoblotting and mRNA analysis demonstrated that emerin level is increased in regenerating rat muscle fibers with ...
S Squarzoni, P Sabatelli, C Capanni, G Lattanzi, C Rutigliano, M Columbaro   +5 more
doaj   +7 more sources

MAPK signaling pathways and HDAC3 activity are disrupted during differentiation of emerin-null myogenic progenitor cells

Disease Models & Mechanisms, 2017
Mutations in the gene encoding emerin cause Emery–Dreifuss muscular dystrophy (EDMD). Emerin is an integral inner nuclear membrane protein and a component of the nuclear lamina. EDMD is characterized by skeletal muscle wasting, cardiac conduction defects
Carol M. Collins, Joseph A. Ellis, James M. Holaska   +2 more
doaj   +2 more sources

An Emerin LEM-Domain Mutation Impairs Cell Response to Mechanical Stress

Cells, 2019
Emerin is a nuclear envelope protein that contributes to genome organization and cell mechanics. Through its N-terminal LAP2-emerin-MAN1 (LEM)-domain, emerin interacts with the DNA-binding protein barrier-to-autointegration (BAF).
Ana A Arteni, Ambre Petitalot, Catherine Coirault   +2 more
exaly   +3 more sources