Emerin increase in regenerating muscle fibers
European Journal of Histochemistry, 2009 The fate of emerin during skeletal muscle regeneration was investigated in an animal model by means of crush injury. Immunofluorescence, immunoblotting and mRNA analysis demonstrated that emerin level is increased in regenerating rat muscle fibers with ...
S Squarzoni +5 more
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C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin [PDF]
eLifeThe inner nuclear membrane (INM), a subdomain of the endoplasmic reticulum (ER), sequesters hundreds of transmembrane proteins within the nucleus. We previously found that one INM protein, emerin, can evade the INM by secretory transport to the lysosome,
Jessica Mella +3 more
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Emerin mislocalization during chromatin bridge resolution can drive prostate cancer cell invasiveness in a collagen-rich microenvironment [PDF]
Experimental and Molecular MedicineMicronuclei (MN) can form through many mechanisms, including the breakage of aberrant cytokinetic chromatin bridges. The frequent observation of MN in tumors suggests that they might not merely be passive elements but could instead play active roles in ...
Marta Popęda +20 more
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Role of Emerin in regulating fibroblast differentiation and migration at the substrate of stiffness coupled topology [PDF]
Acta Biochimica et Biophysica SinicaIn hypertrophic scars, the differentiation and migration of fibroblasts are influenced by the extracellular matrix microenvironment, which includes factors such as stiffness, restraint, and tensile force.
Yang Tiantian +15 more
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Mechanical Stress Triggers Premature Senescence in Cardiac Fibroblasts. [PDF]
Adv Sci (Weinh)Cellular senescence contributes to disease burden in cardiovascular disease (CVD) and aging, highlighting the need to understand its induction. In primary cardiac fibroblasts, reduced strain and increased frequency, mimicking CVD, elicit a distinct senescent phenotype compared to oxidative stress.
Schneider SE +5 more
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Temporal Stretch-Induced Nuclear Mechanosensing Coordinates Early Chromatin Accessibility and Genome Protection. [PDF]
Adv Sci (Weinh)Cyclic stretching of fibroblasts triggers coordinated nuclear mechanosensing events, including calcium ion release, perinuclear actin assembly, emerin translocation, and H3K9me3 loss, increasing chromatin accessibility for specific genes related to mechanotransduction and repair.
Shim HW +10 more
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The Role of Emerin in Cancer Progression and Metastasis [PDF]
International Journal of Molecular Sciences, 2021 It is commonly recognized in the field that cancer cells exhibit changes in the size and shape of their nuclei. These features often serve as important biomarkers in the diagnosis and prognosis of cancer patients. Nuclear size can significantly impact cell migration due to its incredibly large size.
Alexandra G. Liddane, James M. Holaska
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Loss of emerin alters myogenic signaling and miRNA expression in mouse myogenic progenitors. [PDF]
PLoS ONE, 2012 Emerin is an integral membrane protein of the inner nuclear membrane. Mutations in emerin cause X-linked Emery-Dreifuss muscular dystrophy (EDMD), a disease characterized by skeletal muscle wasting and dilated cardiomyopathy.
Adam J Koch, James M Holaska
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Open Biology, 2023 Mitotic exit requires the dephosphorylation of many proteins whose phosphorylation was needed for mitosis. Protein phosphatase 2A with its B55 regulatory subunit (PP2A-B55) promotes this transition.
Virginie Emond-Fraser +8 more
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The nuclear envelope LEM-domain protein emerin [PDF]
Nucleus, 2013 Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for which extensive basic knowledge--biochemistry, partners, functions, localizations, posttranslational regulation, roles in development and links to human disease--is available.
Berk, Jason M +2 more
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