Results 31 to 40 of about 2,917 (255)

SIRTain regulators of premature senescence and accelerated aging. [PDF]

, 2015
The sirtuin proteins constitute class III histone deacetylases (HDACs). These evolutionarily conserved NAD(+)-dependent enzymes form an important component in a variety of cellular and biological processes with highly divergent as well as convergent ...
Ghosh, S, Zhou, Z
core   +1 more source

Dilated cardiomyopathy: reconceptualization of the problem

Российский кардиологический журнал, 2019
Dilated cardiomyopathy (DCM) is a complex, etiologically heterogeneous myocardial disease, which is one of the main causes of heart failure and heart transplantation.
T. G. Vaykhanskaya, L. N. Sivitskaya, T. V. Kurushko, O. D. Levdansky, N. G. Danilenko   +4 more
doaj   +1 more source

Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS [PDF]

, 2018
Defects in stress response are main determinants of cellular senescence and organism aging. In fibroblasts from patients affected by Hutchinson-Gilford progeria, a severe LMNA-linked syndrome associated with bone resorption, cardiovascular disorders, and
Andrenacci, Davide, Cicchilitti, Lucia, Di Blasio, Anna Maria, Garofalo, Cecilia, Gentilini, Davide, Lattanzi, Giovanna, Mai, Antonello, Mattioli, Elisabetta, Piaggio, Giulia, Prencipe, Sabino, Remondini, Daniel, Scarano, Emanuela, Scotlandi, Katia, Valente, Sergio   +13 more
core   +2 more sources

Lipodystrophic laminopathies: Diagnostic clues [PDF]

Nucleus, 2018
The nuclear lamina is a complex reticular structure that covers the inner face of the nucleus membrane in metazoan cells. It is mainly formed by intermediate filaments called lamins, and exerts essential functions to maintain the cellular viability. Lamin A/C provides mechanical steadiness to the nucleus and regulates genetic machinery.
Cristina Guillín-Amarelle, Antía Fernández-Pombo, Sofía Sánchez-Iglesias, David Araújo-Vilar   +3 more
openaire   +3 more sources

Integrated high-content quantification of intracellular ROS levels and mitochondrial morphofunction [PDF]

, 2016
Oxidative stress arises from an imbalance between the production of reactive oxygen species (ROS) and their removal by cellular antioxidant systems.
A Boveris, A Boveris, A Gomes, A Muchir, A Pastore, A Stangherlin, AB Salmon, AJ Meyer, AR Cardoso, AS Rambold, B Babior, B Chazotte, B Groitl, B Zhao, BC Dickinson, BC Dickinson, BC Dickinson, BC Dickinson, C Nathan, C Szabó, C Thomas, C-C Chiu, CA Glasbey, CC Winterbourn, CL Grek, CM Cremers, CT Dooley, D Giustarini, D Han, D Harman, D Poburko, D Staljanssens, DG Nicholls, DS Bilan, EF Iannetti, ET Chouchani, EW Miller, F Auchère, G Loschen, G Rabut, GC Brown, GPC Drummen, GS Baird, GT Hanson, H Dong, H Zhao, HH Rasmussen, J Estaquier, J Zielonka, JD Lambeth, JF Turrens, JF Woolley, JJ Hu, JR Casey, JS Moylan, K Bedard, K Trudeau, KA Lukyanov, KM Robinson, KM Robinson, KN Markvicheva, L Blanchet, LC Gomes, LK Huang, M Benhar, M Bociąga-Jasik, M Caron, M Conte Lo, M Forkink, M Fujikawa, M Giorgio, M Gutscher, M Gutscher, M Lebiedzinska, M Marí, M Zheng, MCY Chang, MG Traber, MJ Saaranen, MM Frigault, MM Tarpey, MP Murphy, MP Murphy, N Castelein, NM Mishina, O Touzet, P Back, P Lopert, P Matarrese, PHGM Willems, PK Sahoo, R Boer de, R Dixit, R Franco, R Radi, RA Weisiger, RB Hamanaka, RJ Mailloux, RL Smith, RR Bartz, S Chandra, S Dupre-Crochet, S Marchi, S Miwa, S Sachdev, S Topell, S Verkaart, SC Gupta, SG Rhee, SI Dikalov, SL Archer, SS Korshunov, T Finkel, T Nakamura, T Roumier, T Sieprath, T Sieprath, T Xiang, TA Prime, TZ Yu, VLRM Verstraeten, VV Belousov, W Naderi, WH Vos De, WJH Koopman, WJH Koopman, WJH Koopman, WJH Koopman, X Wang, Y Riahi, Z-H Chen   +130 more
core   +2 more sources

TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders [PDF]

, 2008
Aicardi-Goutieres syndrome (AGS) is an unusual condition that clinically mimics a congenital viral infection. Several genes have recently been implicated in the aetiology of this disorder. One of these genes encodes the DNA exonuclease TREX1. Recent work
Aicardi, Akira, Alderton, Alderton, Bartek, Bartkova, Brennan, Brucet, Chen, Chowdhury, Crow, Crow, de Silva, DiTullio, Driscoll, Gasser, Griffith, Griffiths, Höss, Jazayeri, Kawai, Lee-Kirsch, Lee-Kirsch, Lieberman, Lieberman, Lindahl, Lindahl, Liu, Liu, Liu, Mark O’Driscoll, Martinvalet, Mazur, Mazur, Morita, Napirei, O’Driscoll, O’Driscoll, Qiu, Raulet, Rhodes, Rice, Richards, Shevelev, Stiff, Stiff, Takaoka, Tran, Tsukumo, Vyse, Walport, Yang, Yasutomo, Zou, Zou   +54 more
core   +1 more source

PRIMARY (GENETICALLY DETERMINED) DILATION CARDIOMYOPATHY IN A PATIENT WITH NOVEL MUTATION OF LAMIN GENE: CLINICAL AND MORPHOLOGICAL MANAGEMENT

Кардиоваскулярная терапия и профилактика, 2017
The primary diagnosis of “dilation cardiomyopathy” is syndromal, and demands clarification of nosological origins. In the article, the specifics of such diagnostics is discussed.
O. V. Blagova, I. N. Alieva, A. V. Nedostup, V. A. Sulimov, E. A. Kogan, A. G. Shestak, D. A. Zateyshchikov, E. V. Zaklyazminskaya   +7 more
doaj   +1 more source

Consequences of Lmna Exon 4 Mutations in Myoblast Function

Cells, 2020
Laminopathies are causally associated with mutations on the Lamin A/C gene (LMNA). To date, more than 400 mutations in LMNA have been reported in patients.
Déborah Gómez-Domínguez, Carolina Epifano, Fernando de Miguel, Albert García Castaño, Borja Vilaplana-Martí, Alberto Martín, Sandra Amarilla-Quintana, Anne T Bertrand, Gisèle Bonne, Javier Ramón-Azcón, Miguel A Rodríguez-Milla, Ignacio Pérez de Castro   +11 more
doaj   +1 more source

Epithelial stem cells In Hutchinson-Gilford progeria syndrome [PDF]

, 2015
Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) are two rare genetic disorders that affect children. Complications from cardiovascular disease, including atherosclerosis, are the most common cause of death in HGPS, which ...
McKenna, Tomás
core   +1 more source

Mouse models of the laminopathies [PDF]

Experimental Cell Research, 2007
The A and B type lamins are nuclear intermediate filament proteins that comprise the bulk of the nuclear lamina, a thin proteinaceous structure underlying the inner nuclear membrane. The A type lamins are encoded by the lamin A gene (LMNA). Mutations in this gene have been linked to at least nine diseases, including the progeroid diseases Hutchinson ...
Colin L, Stewart, Serguei, Kozlov, Loren G, Fong, Stephen G, Young   +3 more
openaire   +2 more sources