Results 171 to 180 of about 14,738 (282)

Developmental regulation of linkers of the nucleoskeleton to the cytoskeleton during mouse postnatal retinogenesis [PDF]

, 2013
Hodzic, Didier, Kolb, Thorsten, Razafsky, David S, Ward, Candace L   +3 more
core   +2 more sources

Simtuzumab Attenuates Loxl2-Mediated Extracellular Matrix Remodeling and Preserves Cardiac Function in <i>LMNA</i> Mutation-Induced Dilated Cardiomyopathy. [PDF]

Circ Heart Fail
Kervella M, Behrens CS, Peccate C, Guesmia Z, Grandi F, Mougenot N, Forand A, Charrabi A, Brochier G, Andriantsitohaina R, Singh SR, Eschenhagen T, Meli AC, Muchir A.   +13 more
europepmc   +1 more source

Systemic Propagation of STING Signalling via Generation of Large Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT Large extracellular vesicles (EVs) derived from tumour cells play important roles in tumour formation and progression. However, it remains unclear why malignant cells produce these EVs and how they act in vivo. We employ a well‐characterized Drosophila tumour model and demonstrate that large EV biogenesis from malignant cells is an ...
Jiae Lee, Annabel Vernon, Hyung Joon Park, Young V. Kwon   +3 more
wiley   +1 more source

The Eubacterium Rectale Derived Extracellular Vesicles Alleviate Cancer Cachexia Induced Lipolysis by Inhibiting Macrophage Polarization

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT Cancer cachexia (CC) is a complex pathological condition associated with cancer progression and poor prognosis, particularly in gastrointestinal cancers, and is closely linked to the gut microbiota. Lipolysis in CC may play a key role in driving cachexia progression.
Jiaqi Wang, Gulisudumu Maitiabula, Sirui Liu, Ruowen Li, Shijie Wang, Pinwen Zhou, Yufei Xia, Longchang Huang, Xin Chen, Xuejin Gao, Li Zhang, Xinying Wang   +11 more
wiley   +1 more source

Correction: An evolutionarily conserved role for separase in the regulation of nuclear lamins. [PDF]

Cell Death Discov
Cipressa F, Pennarun G, Bosso G, Rosignoli S, Tullo L, Schiralli N, Di Dio C, Borghi C, Paiardini A, Esposito G, Goldberg ML, Bertrand P, Cenci G.   +12 more
europepmc   +1 more source

Computational Characterization of the Role of LEM2/LaminA Interactions on the Stability of BAF‐Dimer Using Molecular Simulations

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 5, Page 1104-1114, May 2026.
ABSTRACT The effect of the presence of the BAF‐binding LEM‐domain and LaminA Ig‐fold on the stability of the BAF dimer was studied qualitatively using non‐equilibrium pull simulations and quantitatively through the calculation of the potential of mean force profile along BAF–BAF separation distance.
Aswin Vinod Muthachikavil, Alexander von Appen, Thomas D. Kühne   +2 more
wiley   +1 more source

The dual guardians of cellular stability: exploring nesprin and lamin in senescence. [PDF]

Cell Death Dis
Zhou ZY, Qin Q, Dong C, Liu Y, Cao C, Teng L.   +5 more
europepmc   +1 more source

Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons

Aging Cell, Volume 25, Issue 5, May 2026.
Neurons expressing APOE2 were more resistant to endogenous DNA damage, activated transcriptional signaling pathways associated with DNA repair, and were resilient to stress‐induced DNA damage and cellular senescence. In contrast, APOE4 neurons exhibited elevated expression of rRNA repetitive elements and were prone to becoming senescent.
Cristian Gerónimo‐Olvera, Stephen M. Scheeler, Carlos Galicia Aguirre, Genesis Vega‐Hormazabal, Daniela Garcia, Long Wu, Natalia Murad, Kevin Schneider, Kenneth A. Wilson, Nikola T. Markov, Sicheng Song, Jesse Simons, Akos A. Gerencser, Emily Parlan, Sean D. Mooney, Eric Verdin, Judith Campisi, Tara E. Tracy, David Furman, Simon Melov, Lisa M. Ellerby   +20 more
wiley   +1 more source

An evolutionarily conserved role for separase in the regulation of nuclear lamins. [PDF]

Cell Death Discov
Cipressa F, Pennarun G, Bosso G, Rosignoli S, Tullo L, Schiralli N, Di Dio C, Borghi C, Paiardini A, Esposito G, Goldberg ML, Bertrand P, Cenci G.   +12 more
europepmc   +1 more source

Targeting Hyperoxia‐Induced Cellular Senescence in Developing Human Airway Cells: Senomorphics Versus Senolytics Versus Antioxidants

Aging Cell, Volume 25, Issue 5, May 2026.
Supplemental oxygen is critical for premature infants. While initially beneficial, even moderate hyperoxia (< 60% O2) induces detrimental cellular senescence in developing airways with long‐lasting consequences. Senotherapeutics such as Fucoidan, Dasatinib (D) + Quercetin (D + Q), and mitochondrial‐targeted antioxidant MitoQ may be beneficial in ...
Maunick Lefin Koloko Ngassie, Li Y. Drake, Yi Zhu, Yamillie Ortiz, Daniel A. Pfeffer‐Kleemann, Michael A. Thompson, Samantha K. Hamrick, Christina M. Pabelick, Y. S. Prakash   +8 more
wiley   +1 more source