Results 61 to 70 of about 39,159 (175)

Hepatitis B in Organ Transplantation—Current Evidence and Clinical Gaps

Transplant Infectious Disease, EarlyView.
ABSTRACT Over the past several decades there have been significant advances in nucleos(t)ide analogue (NA) antiviral therapy for hepatitis B virus (HBV) and global expansion of primary prevention through immunization. Despite this, HBV remains a leading cause of chronic liver disease globally, affecting over 250 million people.
Oscar A. Fernandez‐Garcia, Britta L. Hirsch, Irene A. Abela, Karen E. Doucette   +3 more
wiley   +1 more source

Tenofovir as Rescue Therapy Following Clinical Failure to Lamivudine in Severe Acute Hepatitis B

Mediterranean Journal of Hematology and Infectious Diseases, 2013
Acute hepatitis B (AHB) is a self-limiting condition in more than 95% of cases. Treatment is however recommended in patients with severe AHB (
Jurgen Gerada, Elaine Borg, Denise Formosa, Rosalie Magro, James Pocock   +4 more
doaj   +1 more source

Gaps in the HIV Care Continuum: Late Presentation, Disengagement From Care and Lack of Viral Suppression in People With HIV in Ethiopia

Tropical Medicine &International Health, EarlyView.
ABSTRACT Objectives People living with HIV (PLHIV) with ongoing viremia have the potential for onward transmission. Identifying such individuals throughout the care continuum is therefore important for reducing HIV incidence. This study aimed to characterize persons at gaps at different stages of the HIV care continuum in Central Ethiopia.
Ilili J. Abdulahi, Alemseged Abdissa, Patrik Medstrand, Andargachew Mulu, Adane Mihret, Björn Nordberg, Gadissa Merga, Birhanu K. Sori, Hiwot Abayneh, Nahom Assegid, Feben Negash, Meseker Tesfaye, Fregenet Tesfaye, Anton Reepalu, Per Björkman   +14 more
wiley   +1 more source

Extended treatment with lamivudine and adefovir dipivoxil in chronic hepatitis B patients with lamivudine resistance

, 2011
PURPOSE: We and others have reported that adding adefovir dipivoxil (adefovir) to lamivudine results in virological and biochemical improvement in cases of lamivudine resistance.
Perrillo, Robert P, Bernard Willems, Mary Woessner, Carol L. Brosgart, Schiff, Eugene, Stephen D. Gardner, Eugene Schiff, Leung, Nancy, Condreay, Lynn D, Mutimer, David, Lee, William M, Brosgart, Carol L, Nancy Leung, Susan Dixon, Lynn D. Condreay, Gardner, Stephen D, David Mutimer, Willems, Bernard, Robert P. Perrillo, Dixon, Susan, Hie-Won Hann, William M. Lee, Hann, Hie-Won, Woessner, Mary   +23 more
core   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Changes of HBsAg levels in HIV/HBV-coinfected patients with lamivudine-resistant HBV or lamivudine-susceptible HBV on tenofovir-containing combination antiretroviral therapy

, 2016
Changes of HBsAg levels in HIV/HBV-coinfected patients with lamivudine-resistant HBV or lamivudine-susceptible HBV on tenofovir-containing combination antiretroviral ...
Sui-Yuan Chang (39460), Hsin-Yun Sun (61134), Kuan-Yeh Lee (523493), Yi-Ching Su (734372), Shan-Chwen Chang (91714), Wang-Huei Sheng (103262), Wen-Chun Liu (61140), Yu-Shan Huang (847180), Chien-Ching Hung (61132), Yu-Chung Chuang (236282)   +9 more
core   +1 more source

Machine Learning and Structural Analysis for Generation‐Wise Selection of Perylene Diimide Dendrimers Based on Topological Compatibility With Drug Molecules

ChemistryOpen, Volume 15, Issue 11, November 2026.
Machine learning and graph‐theoretic descriptors are integrated to evaluate topology‐based compatibility between perylene diimide‐core dendrimer generations and antiviral, antioxidant, and imaging agents. Standardized structural similarity reveals generation‐dependent compatibility patterns, while Gaussian process regression uncovers key structure ...
Zainab Bibi, Jabbar Ali, Sana Irshad, Muhammad Saad Ghafar, Yasir Ali, Yilun Shang   +5 more
wiley   +1 more source

Long-term efficacy of dolutegravir plus lamivudine for maintenance of HIV viral suppression in adults with and without historical resistance to lamivudine: Week 96 results of ART-PRO pilot study

, 2021
Background: In the ART-PRO pilot trial there were no virological failures through 48 weeks of treatment with dolutegravir plus lamivudine in suppressed individuals with and without archived lamivudine resistance-associated mutations (RAMs) detected ...
Delgado Vázquez, Rafael, Pulido Ortega, Federico, Arribas JR, Rial Crestelo, David, Rubio García, Rafael   +4 more
core   +1 more source

Validação de método por cromatografia líquida de alta eficiência para determinação da lamivudina e zidovudina em comprimidos Validation of a high performace liquid chromatography method for the determina of lamivudine and zidovudine in tablets

Química Nova, 2007
An HPLC method was validated to assay lamivudine and zidovudine combined in tablets. The chromatographic separation was carried out using methanol and acetate buffer pH 6.5 (50:50 v/v) and a RP-18 column, as mobile and stationary phase, respectively. The
Ruy Carlos Ruver Beck, Simone Gonçalves Cardoso, Margareth Linde Athayd, Cristiane Codevilla, Fernanda Kreutz de Oliveira, Sérgio Luiz Dalmora   +5 more
doaj   +1 more source