Results 131 to 140 of about 24,362 (263)

Intermittent fasting with medium‐chain triglycerides in drug‐resistant epilepsy: A pilot crossover trial

Epilepsia, EarlyView.
Abstract Objective Ketogenic dietary therapies can reduce seizure frequency in drug‐resistant epilepsy, but adherence to the classical ketogenic diet is often poor. Intermittent fasting supplemented with medium‐chain triglycerides (MCTs) may offer a more feasible and less restrictive alternative.
Wiebke Hahn, Emily Falk, Ayla Balzter, Tobias Foer, Shanin Maierhofer, Sophia Jaumann, Sascha Strehlau, Leona Möller, Panagiota‐Eleni Tsalouchidou, Katja Menzler, Lars Timmermann, Susanne Knake   +11 more
wiley   +1 more source

Effects of lamotrigine alone and in combination with MK-801, phenobarbital, or phenytoin on cell death in the neonatal rat brain

, 2007
The neonatal rat brain is vulnerable to neuronal apoptosis induced by antiepileptic drugs (AEDs), especially when given in combination. This study evaluated lamotrigine alone or in combination with phenobarbital, phenytoin, or the glutamate antagonist (+)
Kim, Jinsook, Kondratyev, Alexei, Gale, Karen, Katz, Irina   +3 more
core   +1 more source

SUDEP and mortality in developmental and epileptic encephalopathies: A meta‐analysis of randomized clinical trials and extension studies

Epilepsia, EarlyView.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are associated with high premature mortality and increased risk of sudden unexpected death in epilepsy (SUDEP). However, epidemiological data remain limited, particularly for specific syndromes such as Dravet syndrome (DS), Lennox–Gastaut syndrome (LGS), and infantile epileptic ...
Pierludovico Moro, Maria Sole Borioni, Adolfo Mazzeo, Enrico Cocchi, Carlo Di Bonaventura, Emanuele Cerulli Irelli   +5 more
wiley   +1 more source

The effect of raltegravir on the glucuronidation of lamotrigine.

, 2009
Contains fulltext : 81310.pdf (Publisher’s version ) (Closed access)The authors studied the effect of raltegravir on the pharmacokinetics of the antiepileptic agent lamotrigine.
Burger, D.M., Kolk, M. van der, Luin, M. van, Silva, H.G. da, Ewijk-Beneken Kolmer, E.W.J. van, Verwey-van Wissen, C.P.W.G.M., Colbers, A., Hoitsma, A.J.   +7 more
core   +1 more source

Insights into ANKRD11‐related epilepsy from 163 people

Epilepsia, EarlyView.
Abstract Objective Ankyrin repeat domain 11 gene (ANKRD11) is the key disease gene for autosomal dominant KBG syndrome, and a subset of affected individuals develop epilepsy. However, comprehensive characterization of epilepsy‐related phenotypes and genotype–phenotype correlations in ANKRD11 variant carriers remains limited.
Song Su, Jian Ma, Qi Zhang, Wandong Hu, Ying Ren, Wenchao Zhang, Hongwei Zhang   +6 more
wiley   +1 more source

Effect of Lamotrigine on Refractory Epilepsy: Clinical Outcomes and EEG Changes

Zheng Li,1,* Peng Wu,1,* Qiushuo Chen,2 Xinqiang Tong,1 Qichao Yang1 1Shijiazhuang Rongkang Hospital of Traditional Chinese Medicine Co., Ltd., Internal Medicine, Shijiazhuang, 050000, People’s Republic of China; 2Department of Neurology, Baoding
Chen Q, Li Z, Wu P, Tong X, Yang Q
core  

Lopinavir/ritonavir reduces lamotrigine plasma concentrations in healthy subjects.

, 2006
Contains fulltext : 50676.pdf (Publisher’s version ) (Open Access)BACKGROUND: Limited data are available about the effect of lopinavir and low-dose ritonavir on glucuronidation. Lamotrigine undergoes glucuronidation.
Burger, D.M., Hofstede, H.J.M. ter, Caliskan-Yassen, N., Lee, M.J. van der, Graaff, M.J.A. de, Ewijk-Beneken Kolmer, E.W.J. van, Koopmans †, P.P., Dawood, L.   +7 more
core   +1 more source

Semiology of functional/dissociative seizures in idiopathic generalized epilepsy: An inpatient video‐electroencephalographic study

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to estimate the prevalence and characterize the semiology of co‐occurring functional/dissociative seizures (FDSs) and identify clinical features potentially associated with the development of video‐electroencephalography (video‐EEG)‐diagnosed FDSs in patients with idiopathic generalized epilepsy (IGE ...
Javier Peña‐Ceballos, Kishen Radhakrishna, Tenzin Choekyi, Clodagh O'Keeffe, Mohamed Ali, Alma O'Donnell, Tudor Munteanu, Patrick B. Moloney, Hany El Naggar, Gerard Mullins, Peter Widdess‐Walsh, Ronan D. Kilbride, Norman Delanty, Nuala McNicholas   +13 more
wiley   +1 more source

Lipid‐based Nano‐delivery systems as a promising strategy for the treatment of epilepsy: Current status and challenges

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini, Arunachalam Divya, Kumar Sowndharya, Parthiban Jeevitha, Selvam Manoj, Ashiq Rahman, Athil Ahamed, Ravichandiran Abirahul, Paranthaman Subash, Sulekha Khute   +9 more
wiley   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source