Results 141 to 150 of about 20,608 (229)

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 2161-2165, October 2026.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi, Enrique Gonzalez Saez‐Diez, Joshua Rong, Beril Ay, Shabbir Merchant, Kathryn Yang, Darius Ebrahimi‐Fakhari   +6 more
wiley   +1 more source

Melatonin Levels in 89 Individuals With Smith Magenis Syndrome

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2260-2272, October 2026.
ABSTRACT In patients with Smith–Magenis syndrome (SMS), an inverted circadian rhythm of melatonin (MT) contributes to the sleep disturbance. Standard treatment of sleep disturbance with MT often leads to extremely high daytime MT levels, resulting in even more sleep disorders. We therefore retrospectively evaluated the MT data of 89 SMS patients.
Wiebe Braam, Ann C. M. Smith
wiley   +1 more source

Comprehensive insights into the prescribing trends of carbamazepine, lamotrigine, lithium, and valproate in the UK Primary Care from 1995 to 2018. [PDF]

PLoS One
Samsuddin SW, Bazo-Alvarez JC, Schartau P, Petersen I.   +3 more
europepmc   +1 more source

Case‐malformed signal detection and prioritisation using EUROmediCAT data for pharmacovigilance in pregnancy

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3586-3597, October 2026.
Aim Many women take medications during pregnancy. However, the risk to the fetus from most medications is uncertain. Congenital anomalies are one of the leading causes of infant death and contribute to long‐term disability. Signal detection methods can be used to systematically identify possible medication–anomaly associations that require further ...
Hannah Johnson, Helen Dolk, Maria Loane, Christine Damase‐Michel, Joanne Given, Hedvig Nordeng, Jorieke E. H. Bergman, Iain Carey, Elly Den Hond, Ester Garne, Florence Rouget, Lea Bruneau, Isabelle Monier, Anke Rissmann, Mary O'Mahony, Miriam Gatt, Renée Lutke, Joanna Sichitiu, Elisa Ballardini, Alessio Coi, Clara Cavero Carbonell, David Tucker, Joan Morris   +22 more
wiley   +1 more source

Breath Signatures of Antiseizure Medication Response and Tolerability in Adults With Epilepsy

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Breath metabolomic profiles distinguish treatment response and adverse effects in adults with epilepsy, whereas serum antiseizure medication concentrations do not. These findings support breath analysis as a non‐invasive approach to pharmacodynamic phenotyping, capturing treatment‐related metabolic states relevant to complex human disease.
Kai Fricke, Diego Manuel Baur, Kapil Dev Singh, Felix Schmidt, Kathrin Müsch, Noriane Andrina Sievi, Marco Di Donato, Anton Schmick, Silvia Ulrich, Pablo Sinues, Marian Galovic, Malcolm Kohler   +11 more
wiley   +1 more source

Trends in Use of Antiseizure Medicines in Women With Epilepsy in Pregnancy During 2018-2023 in an Irish Maternity Hospital: A Cohort Study. [PDF]

Obstet Gynecol Int
Devin JE, O'Shaughnessy F, Cleary BJ, Donnelly JC, Maher N.   +4 more
europepmc   +1 more source

Updated Estimates of Agreement Between Dispensed Medications and Forensic Toxicology in Sweden

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 10, October 2026.
ABSTRACT Purpose To present updated estimates from a nationwide Swedish study comparing dispensed medications with forensic toxicological findings (2006–2013), following re‐evaluation of the toxicology dataset to address periods with non‐uniform analytical detection and inconsistent testing.
Heidi Taipale, Jari Tiihonen, Antti Tanskanen, Jonas Forsman   +3 more
wiley   +1 more source

Medicine Use Preceding Fatal Poisonings Among Individuals With Bipolar Disorder

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Pharmacotherapy may reduce overall suicide risk in bipolar disorder, but prescribed medicines can also be causative agents in suicidal and accidental poisonings. This nationwide, nested case–control study utilized data from several national registers in Finland in 1996–2018.
Janina Salmelainen, Miia Tiihonen, Heidi Taipale, Johannes Lieslehto, Antti Tanskanen, Jari Tiihonen, Aleksi Hamina   +6 more
wiley   +1 more source

Lamotrigin [PDF]

, 2018
C. Vidal, W.-R. Külpmann
openaire   +2 more sources