Results 171 to 180 of about 19,789 (243)

Drug-Metabolizing Enzymes in Human Keratinocytes and In Vitro Detection of Cytochrome P450-Mediated Phenolic Lamotrigine Metabolite. [PDF]

Chem Res Toxicol
Deck PN, Müller M, Glässner A, Vogel M, Steffens M, Heubach C, Fechner G, Becker K, Weindl G, Sachs B.   +9 more
europepmc   +1 more source

Progressive myoclonus epilepsy in Down syndrome with Alzheimer's disease: An 11‐year longitudinal study and proposed diagnostic red flags

Epilepsia Open, Volume 11, Issue 4, Page 1200-1213, August 2026.
Abstract Objective Individuals with Down syndrome (DS) face an ultra‐high risk of Alzheimer's disease (AD). Within this continuum, Progressive Myoclonus Epilepsy (PME) has emerged as a marker of advanced neurodegeneration. Building on our 2014 characterization of this syndrome, we aimed to define its long‐term natural history and pathological substrate.
Giuseppe d'Orsi, Ezio Calò, Maria Teresa Di Claudio, Carmela Pia Ferro, Umberto Costantino, Elio Perrone, Raffaela Rita Latino   +6 more
wiley   +1 more source

Did the French pregnancy pictogram change antiseizure medication use during pregnancy? [PDF]

Epilepsia
Araujo M, Damase-Michel C, Denuelle M, Boulogne S, Delteil L, Saucedo M, Deneux-Tharaux C, Lacroix I.   +7 more
europepmc   +1 more source

Effectiveness and safety of implantable vagus nerve stimulation in people with primary generalized tonic–clonic seizures

Epilepsia Open, Volume 11, Issue 4, Page 1214-1226, August 2026.
The impact of prompt diagnosis and treatment, and early predictors of outcome severity in this cohort. Abstract Objective Most therapies for drug‐resistant epilepsy (DRE) focus on focal‐onset seizures, the most common seizure types. Studying primary generalized tonic–clonic seizures (PGTCS) is more challenging due to diagnostic and recruitment ...
Katherine Eggleston, Justine Curley, Ryan Verner, Maxine Dibue, Charles Gordon, Gaia Giannicola, Kathryn Nichol   +6 more
wiley   +1 more source

Hypersensitivity reaction risk when restarting cenobamate after discontinuation: Insights from a prolonged hospitalized cohort

Epilepsia Open, Volume 11, Issue 4, Page 1255-1262, August 2026.
Abstract Objective To evaluate the risk of hypersensitivity reactions, including dermatological rashes, when cenobamate (CNB) is restarted at maintenance doses after temporary discontinuation. Methods We leveraged the natural experiment of long antiseizure medication discontinuation during intracranial EEG evaluation and conducted a retrospective ...
Marina Feldman, Andreas Alexopoulos, Juan Bulacio, Dileep Nair, Vineet Punia   +4 more
wiley   +1 more source

Trends in paediatric antiseizure-medication use and costs in France, 2014-2023: a nationwide population-based analysis. [PDF]

Lancet Reg Health Eur
Nabbout R, Santilli A, Tyvaert L, Schweitzer C, Maillard L, Kuchenbuch M.   +5 more
europepmc   +1 more source

Beyond seizures: A multidimensional approach to non‐seizure issues in Lennox–Gastaut syndrome. Insights from Italian experts

Epilepsia Open, Volume 11, Issue 4, Page 1075-1094, August 2026.
Abstract Non‐seizure issues (NSIs), including cognition, behavior/psychiatric symptoms, adaptive and social functioning, sleep, autonomic, and motor impairments, often shape day‐to‐day outcomes in Lennox–Gastaut syndrome (LGS) more than seizures, yet clinicians lack LGS‐specific, feasible assessment pathways.
Giancarlo Di Gennaro, Domenica Immacolata Battaglia, Paolo Bonanni, Gian Marco Duma, Antonietta Coppola, Edoardo Ferlazzo, Dario Pruna, Carlo Di Bonaventura   +7 more
wiley   +1 more source

Optimization of the composition of temperature-responsive polymers for spin columns. [PDF]

Sci Rep
Nagase K, Kokubun M, Kanazawa H.
europepmc   +1 more source

Occurrence and clinical correlates of depressive symptoms in adults with epilepsy: A study in Georgia

Epilepsia Open, Volume 11, Issue 4, Page 1290-1300, August 2026.
Abstract Objective To evaluate the occurrence, clinical correlates, and screening accuracy of depressive symptoms (DS) among adults with epilepsy in Georgia, a country with limited mental health resources. Methods We conducted a cross‐sectional study in adults with epilepsy attending a tertiary care center. We assessed DS using two validated tools: the
Ketevan Silagadze, Eka Burkadze, Maka Areshidze, Teimuraz Silagadze, Sofia Kasradze, Josemir W. Sander   +5 more
wiley   +1 more source

The Efficacy of Combined Lamotrigine and Levetiracetam Therapy in Epileptic Patients and Its Effects on Hippocampal Volume and Neuroinflammatory Response. [PDF]

J Inflamm Res
Li P, Qi A, Ma J, Li A, Sun Z.
europepmc   +1 more source