Results 31 to 40 of about 623,540 (297)

Searching for improvement [PDF]

, 2006
Engineering design can be thought of as a search for the best solutions to engineering problems. To perform an effective search, one must distinguish between competing designs and establish a measure of design quality, or fitness.
Atherton, MA, Bates, RA
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Mitigating Ni and Cu ecotoxicity in the ecological restoration material and ornamental Primula forbesii Franch. with exogenous 24-epibrassinolide and melatonin

Scientific Reports
Nickel (Ni) and copper (Cu) contamination have become major threats to plant survival worldwide. 24-epibrassinolide (24-EBR) and melatonin (MT) have emerged as valuable treatments to alleviate heavy metal-induced phytotoxicity.
Hongchen Yang, Jian Zhao, Xiancai Yin, Keying Ding, Xinhui Gao, Yuxin Cai, Yuanzhi Pan, Beibei Jiang, Qinglin Liu, Yin Jia   +9 more
doaj   +1 more source

Bipolarity and Ambivalence in Landscape Architecture [PDF]

, 2010
Our discipline of landscape architecture contains bipolarity, not only in terms of landscape and architecture but also because the idea of landscape is both aesthetic and scientific.
Koh, J.
core   +1 more source

Effects of Epistasis and Pleiotropy on Fitness Landscapes

, 2013
The factors that influence genetic architecture shape the structure of the fitness landscape, and therefore play a large role in the evolutionary dynamics. Here the NK model is used to investigate how epistasis and pleiotropy -- key components of genetic
A Dawid, AI Khan, B Østman, DJ Kvitek, FJ Poelwijk, H Chou, HA Orr, MC Whitlock, MC Whitlock, MM Desai, RL Unckless, S Gavrilets, S Gavrilets, S Kauffman, S Kauffman, V Mustonen   +15 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Taxonomic status and spatial genetic pattern of Taxus in northern and central China: insights from integrative taxonomy, ecology and phylogeography

BMC Plant Biology
Background Phenotypic, ecological, and genetic differences are crucial for species delimitation and understanding speciation. However, the defining the distribution boundaries and mechanisms driving lineage differentiation of Taxus species in northern ...
Chuncheng Wang, Minqiu Wang, Shaolong Yang, Xintong Wu, Shanshan Zhu, Yadan Yan, Jing Xu, Yafeng Wen   +7 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Transcriptomics analyses reveal the key genes involved in stamen petaloid formation in Alcea rosea L.

BMC Plant Biology
Alcea rosea L. is a traditional flower with a long cultivation history. It is extensively cultivated in China and is widely planted in green belt parks or used as cut flowers and potted ornamental because of its rich colors and flower shapes.
Yuanzhi Luo, Yifeng Li, Xiancai Yin, Wanqing Deng, Jianwei Liao, Yuanzhi Pan, Beibei Jiang, Hongchen Yang, Keying Ding, Yin Jia   +9 more
doaj   +1 more source

Optimization of Green Spaces in Plain Urban Areas to Enhance Carbon Sequestration

Land, 2023
Global climate change and rapid urbanization have placed enormous pressure on the urban ecological environment worldwide. Urban green spaces, which are an important component of urban ecosystems, can maintain ecological and environmental sustainability ...
Peiyuan Tao, Ye Lin, Xing Wang, Jiayan Li, Chao Ma, Zhenkun Wang, Xinyue Dong, Peng Yao, Ming Shao   +8 more
doaj   +1 more source