Results 41 to 50 of about 623,540 (297)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

PfERF106, a novel key transcription factor regulating the biosynthesis of floral terpenoids in Primula forbesii Franch

BMC Plant Biology
Background Flowers can be a source of essential oils used in the manufacture of substances with high economic value. The ethylene response factor (ERF) gene family plays a key role in regulating secondary metabolite biosynthesis in plants. However, until
Xiancai Yin, Hongchen Yang, Keying Ding, Yuanzhi Luo, Wanqing Deng, Jianwei Liao, Yuanzhi Pan, Beibei Jiang, Xue Yong, Yin Jia   +9 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Effect of Landscape Structure on Land Surface Temperature in Different Essential Urban Land Use Categories: A Case Study in Jiaozuo, China

Land, 2022
Understanding the relationship between different essential urban land use categories and the urban thermal environment is essential for urban planning, resource allocation and decision support.
Xiaoli Jia, Peihao Song, Guoliang Yun, Ang Li, Kun Wang, Kaihua Zhang, Chenyu Du, Yuan Feng, Kexin Qu, Meng Wu, Shidong Ge   +10 more
doaj   +1 more source

Landscape History and Theory: from Subject Matter to Analytic Tool [PDF]

, 2004
This essay explores how landscape history can engage methodologically with the adjacent disciplines of art history and visual/cultural studies.
Birksted, Jan Kenneth
core  

The Dynamic Landscapes of RNA Architecture [PDF]

Cell, 2009
A wealth of information on RNA folding and ribonucleoprotein assembly has emerged from analyses of structures and from the use of innovative biophysical tools. Although integrating data obtained from static structures with dynamic measurements presents major challenges, such efforts are opening new vistas on the RNA folding landscape.
Cruz, José Almeida, Westhof, Eric
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Does visualisation of digital landscapes serve itself : how topographic, planning, environmental and other thematic information is integrated and disseminated via web GIS [PDF]

, 2010
Digital landscapes provide decision makers with readily-available tools that enhance the policy-to-decision process. Malta has been witness to various processes to create digital landscapes for both the professional and the general public.
Agius, Carol, Conchin, Stephen, Digital Landscape Architecture 2010, Formosa, Saviour, Rizzo Naudi, Antonello   +4 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source