Results 51 to 60 of about 623,540 (297)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
PiERF1 regulates cold tolerance in Plumbago indica L. through ethylene signalling
Scientific ReportsEthylene is a signalling factor that plays a key role in the response of plants to abiotic stresses, such as cold stress. Recent studies have shown that the exogenous application of 1-aminocyclopropane-1-carboxylate (ACC), an ethylene promoter, affects ...
Zi-An Zhao +8 more
doaj +1 more source
Chrysanthemum × grandiflora leaf and root transcript profiling in response to salinity stress
BMC Plant Biology, 2022 As high soil salinity threatens the growth and development of plants, understanding the mechanism of plants’ salt tolerance is critical. The Chrysanthemum × grandiflora is a newly developed species with a strong salt resistance that possesses multiple ...
He Liu +7 more
doaj +1 more source
Landscape architecture and health [PDF]
, 2005 Swedes are living increasingly longer lives, but the number of years lived in good health is decreasing. The present doctoral dissertation is focused on the threat to Swedish public health that is constituted by aches and pain and various types of mental
Stigsdotter, Ulrika
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Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Protected areas unevenly contribute to terrestrial vertebrate habitat conservation in China
Communications Earth & EnvironmentEnsuring habitat representativeness is fundamental to area-based conservation, yet the effectiveness and efficiency of individual protected areas in meeting this goal remain underexamined, potentially impeding targeted strategies.
Tz-Hsuan Tseng +7 more
doaj +1 more source
BMC Plant Biology, 2019 Background During tomato cultivation, tomato leaf mould is a common disease caused by Cladosporium fulvum (C. fulvum). By encoding Cf proteins, which can recognize corresponding AVR proteins produced by C. fulvum, Cf genes provide resistance to C. fulvum,
Tingting Zhao +12 more
doaj +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Portland River District park system urban design framework study [PDF]
, 2001 18 pp. Bookmarks supplied by UO. Maps, figures, illus. Published January 16, 2001. Captured September 18, 2009.The Framework Plan: creates a strong and poetic metaphor of historic Tanner Creek; it addresses the deeper meanings of the natural cycle of ...
Opsis Architecture +3 more
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source