Results 101 to 110 of about 305,128 (260)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Spatiotemporal association of urban park characteristics and physical activity levels based on GTWR: A serial cross-sectional observational study

Journal of Urban Management
Physical inactivity poses a significant public health challenge. Numerous studies have argued that urban parks can promote physical activity (PA). However, evidence of physical activity observed over long periods of time in parks is still very lacking ...
Zheng Tao, Junqi Chen, Wenrui Wu, Jiahui Ding, Ling Wang, Zhenhua Zhu, Dan Chen   +6 more
doaj   +1 more source

Retracted: Urban Landscaping Landscape Design and Maintenance Management Method Based on Multisource Big Data Fusion. [PDF]

Comput Intell Neurosci, 2023
Intelligence And Neuroscience C.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Effect of Foliar Spraying with Boron and Ascorbic Acid on Growth and Yield Traits of Chili Pepper Grown in Plastic House

مجلة ديالى للعلوم الزراعية
This study evaluated the effect of foliar spraying with boron (0, 50, and 100 mg L-1) and ascorbic acid (0, 100, and 200 mg L-1) on the growth and yield of chili pepper plants grown in a plastic house. The treatment spraying boron at a rate of 100 mg L-1
Adnan Ghazi Salman Al-nussirawi, Wasam Habeib Altamimi, Jamal Nathir Naji   +2 more
doaj   +1 more source

Traces of health-A landscape design task as a diagnostic aid for detecting mental burden? A qualitative focus group study. [PDF]

Front Psychol, 2023
Niedermann C, Anheyer D, Seeligmüller E, Ostermann T.   +3 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Multimodal Interaction of MU Plant Landscape Design in Marine Urban Based on Computer Vision Technology. [PDF]

Plants (Basel), 2023
Yuan J, Zhang L, Kim CS.
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source