Results 101 to 110 of about 1,182,283 (252)

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

The Effects of Youth Entrepreneurship Community Engagement on Sustainable Design: A Case Study of Guangfu Village Redevelopment

open access: yesE3S Web of Conferences, 2018
Public participation plays a decisive role in the way to achieve sustainability deign for local redevelopment. Guangfu Village, the first garden city model town in Taiwan is facing redevelopment issue when executing sustainable design with human ...
Hsu Kuo-Wei, Chao Chieh-Yu
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

Patches, Corridors, Matrix, Webs and Clouds. Expanding Richard TT Forman’s Land Mosaic Approach in the Medina of Tunis

open access: yesRi-vista: Ricerche per la Progettazione del Paesaggio
This study proposes a framework for analyzing the medina of Tunis, based on Richard T.T. Forman's theory of land mosaics. Departing from traditional preservationist methods, it views the Medina as a multifaceted landscape, integrating both tangible and ...
Gareth Doherty, Areti Kotsoni
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Analysis of ant's habitat in the Quran: potential of the adaptation for sustainable urban landscape design in Malaysia [PDF]

open access: yes, 2015
Majority of the urban dwellers will experience physical urban disarray of a climate change from the unsustainable urban landscape design. Urban landscape design concept and policies in Malaysia fail to produce optimal solution to the threat of climate ...
Ismail, Nor Atiah   +4 more
core  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

A holistic framework for the analysis of landscape changes following organic farming [PDF]

open access: yes, 2003
In this paper I reflect on the design of an appropriate methodological framework for my Ph.D.-project. Holism is widely recognised a vital concept for research on human-environment relationships.
Levin, Gregor
core  

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung   +7 more
wiley   +1 more source

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