Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Cost-Benefit Analysis of Urban Green Infrastructures: A Case Study of the LiuChuan River Corridor, Taichung City, from Linsenliu Bridge to Minquanliu Bridge [PDF]
E3S Web of ConferencesGreen infrastructure has been shown to play the role of adaptation and adjustment under the effect of harsh climate. The creation of urban green infrastructure is an important indicator of sustainable urban development, and determining the cost ...
Chao Jen-Chih, Lin Ji-Yuan
doaj +1 more source
On a landscape approach to design and eco-poetic approach to Landscape [PDF]
For Landscape Architecture to become an academic discipline it must present its own coherent theory and methodology for the planning, designing and management of (built) landscapes.
Koh, J.
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In Defiance of a Stylistic Stereotype: British Crematoria, Architecture, Design and Landscape [PDF]
, 2006 This paper presented a new critical reading of the crematorium, rendered ‘invisible’ by the taboo surrounding death and provided the first opportunity to disseminate this research to an international audience.
Grainger, Hilary J.
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
BMC Plant BiologyThe current investigation considers the synergistic effects of boron (B) and zinc (Zn) on tuber development, tuber quality, and nutrient status prior to and after storage periods.
Muhanad A. Ahmad +9 more
doaj +1 more source
Understanding changes in the landscape based on a Landsat remote sensing analysis in the Karbi Anglong hills, Assam, India [PDF]
, 2016 The landscape of the Karbi Anlong hills (State of Assam, India), south of the Kaziranga National Park, is shaped by small-scale farmers of the Karbi tribe.
Bos, Swen +4 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Participatory design and use of a simplified landscape in a simulation model for mitigating land use conflict in Northern Thailand highlands [PDF]
, 2009 Landscape modelling integrating spatial information in Geographic Information Systems has been widely used to represent knowledge and support decision-making in the field of natural resource management.
Dumrongrojwatthana, P. +3 more
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