Results 61 to 70 of about 305,128 (260)

Study on the Spatiotemporal Patterns and Influencing Factors of Maize Planting in Hunan Province

Agronomy
Maize, one of the world’s three major food crops, plays a vital role in global food security. Analyzing the spatiotemporal patterns of maize cultivation in Hunan Province and their influencing factors contributes to enhancing planting quality and ...
Qinhao Xiao, Xigui Li, Jingyi Ma, Liangwei Zhu, Kequan Gong, Siting Zhan   +5 more
doaj   +1 more source

Examining the role of concrete 3D printing for housing construction on Indigenous Reserves in Canada [PDF]

Frontiers in Engineering and Built Environment
Purpose – This research explores the role of concrete 3D printing (C3DP) in the development of culturally appropriate housing in Indigenous Reserves in Canada through the design, building and evaluation of the Star Lodge project located in the Siksika ...
Mauricio Soto Rubio, Muhammad Fauzan Mirza, Mustafa Kagdi, Ahmad Ali Bisati   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Synergistic effects of boron and zinc foliar applications on growth and post-harvest storage attributes of potato (Solanum tuberosum L.) cultivar Argana

BMC Plant Biology
The current investigation considers the synergistic effects of boron (B) and zinc (Zn) on tuber development, tuber quality, and nutrient status prior to and after storage periods.
Muhanad A. Ahmad, Badran S. Agha, Ahmed I. Y. Alabade, Fathel F. R. Ibraheem, Ayad Hani Alalaf, Ayad T. Shayal Alalam, Ahmed T. Al-Abbasi, Yusra Mohammed Saleh, Esraa Abd-Alhuseein Jasim, Heidar Meftahizade   +9 more
doaj   +1 more source

Spatiotemporal Effects of Urban Park Features on Walking and Running: Evidence from a Long-Term Observational Study in Shanghai

Land
As urban parks become vital settings for public health, understanding how spatial features influence physical activity is essential. This study addresses a research gap by examining how park attributes affect walking and running across different space ...
Junqi Chen, Zheng Tao, Wenrui Wu, Yi Wen, Ling Wang, Dan Chen   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source