Results 51 to 60 of about 1,182,283 (252)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Urban ScienceThe capacity for urban innovation is a significant symbol of contemporary urban development. In order to promote sustainable urban innovation, it is crucial to match and optimize innovation spaces, actors, and their behavioral needs.
Luhui Qi +5 more
doaj +1 more source
Climate and urban design of maritime public spaces in Mediterranean Arab cities [PDF]
, 2013 The traditional urban fabrics in Arab cities along the Mediterranean coast offer an exceptional 'urban lab' to study climatic design, urban patterns and forms applied in public realms.
Suau, Cristian
core
Assessing the value of forest landscapes: a choice experiment approach [PDF]
, 2009 Landscape planning and design occupies a major role in forest policy in the UK. Since the 1980s, UK forests have been managed increasingly for multi-purpose objectives, a policy which has been underpinned by international agreements on sustainable ...
Garrod, G., Ruto, E., Snowdon, P.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The methodology of historic town landscape preservation in China [PDF]
, 2011 This study tried to find a feasible methodology most fitting to historic town landscape preservation and town development in China. With the social, environmental, and economic development in China, historic small towns faded away gradually, either ...
Ma, Xiuwen
core
Modelling and in vitro testing of the HIV-1 Nef fitness landscape. [PDF]
, 2019 An effective vaccine is urgently required to curb the HIV-1 epidemic. We have previously described an approach to model the fitness landscape of several HIV-1 proteins, and have validated the results against experimental and clinical data.
Barton, John P +9 more
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source