Results 31 to 40 of about 305,128 (260)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Influence of Urban Park Pathway Features on the Density and Intensity of Walking and Running Activities: A Case Study of Shanghai City

Land
Walking and running activities (W&RAs), encompassing strolling, slow walking, brisk walking, jogging, and running, hold significant importance as popular forms of exercise within urban parks.
Junqi Chen, Zheng Tao, Wenrui Wu, Ling Wang, Dan Chen   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Visual effect analysis of gates at modern industrial heritage sites in China based on eye-tracking technology and the semantic difference method

Humanities & Social Sciences Communications
This study takes the entrances of three modern industrial heritage sites, including the Nanjing Jinling Arsenal, as its research subjects. By integrating AIGC image restoration technology, eye tracking analysis (ET), and the semantic difference method ...
Hao Li, Miaomiao Qi, Haomiao Tao, Yi Zhu, Ping Zhu   +4 more
doaj   +1 more source

The Spatial Pattern Evolution of Urban Innovation Actors and the Planning Response to Path Dependency: A Case Study of Guangzhou City, China

Urban Science
The capacity for urban innovation is a significant symbol of contemporary urban development. In order to promote sustainable urban innovation, it is crucial to match and optimize innovation spaces, actors, and their behavioral needs.
Luhui Qi, Yuan Zhang, Yuanyi Chen, Lu Chen, Shuli Zhou, Xiaoli Wei   +5 more
doaj   +1 more source

Effect of the Bio-stimulator Amalgerol in some Growth and Yield Properties of Two Sweet Pepper (Capsicum annuum L.) Varieties

Maǧallaẗ al-baṣraẗ al-ʻulūm al-zirāʻiyyaẗ, 2019
The field experiment was conducted during the agricultural season 2016-2017 in one of the greenhouses belonging to the Directorate of Agriculture of Basrah in Khor Al-Zubair, in order to study the effect of the bio-stimulator Amalgerol in some growth ...
Abdul Basset M. Al-Mahdi, Nawal M. Al-Bayaty, Abbas K. Abaid   +2 more
doaj   +1 more source