Results 41 to 50 of about 305,128 (260)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Cultural elements’ influence on visual preferences in urban waterfronts’ walkways in Malaysia

Frontiers in Built Environment
With the rapid urbanization in Malaysia, human activities have caused damage to many waterfront areas. Efforts are being made to restore the connection between the community and river waterfronts while creating attractive urban spaces.
Tun Liu, Tun Liu, Mohd Yazid Mohd Yunos, Adam Aruldewan S. Muthuveeran, Riyadh Mundher, Nor Atiah Ismail   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Optimizing strawberry (Fragaria × ananassa cv. ‘Ruby Gem’) performance and fruit quality using sorbitol and boron foliar sprays

Scientific Reports
This study evaluated the effects of foliar application of sorbitol and boron on vegetative growth, physiological traits, yield, and fruit quality of strawberry (Fragaria × ananassa Duch.) cv. ‘Ruby Gem’. The randomized complete block design (RCBD) of two-
Ahmed T. Al-Abbasi, Yusra Mohammed Sale, Ayad T. Shayal Alalam, Wisam K. Khalid, Badran S. Agha, Muhanad A. Ahmad, Amina Diyaa Al-dabbagh, Ayad Hani Alalaf, Heidar Meftahizadeh   +8 more
doaj   +1 more source

Sustainable Urban Landscape Management: An Insight Into Urban Green Space Management Practices in Three Different Countries

Journal of Landscape Ecology, 2019
To achieve high-quality urban landscape management, it is important to have a proper management system. Some developing countries like Afghanistan are facing a decline of green spaces due to lack of proper management.
Darkhani Faiza, Tahir Osman Mohd, Ibrahim Roziya   +2 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Empirical Research on Regional Revitalization: A Case of Old Urban Railways

Engineering Proceedings
Historically, railway facilities have been intertwined with daily life, communities, geography, and history, contributing to a rich cultural heritage and collective memory.
Wen-Bor Lu, Hsien-Wen Kuo, Chuan-Cheng Wang   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Diurnal Variations in Greenspace Cooling Efficiency and Their Non-Linear Responses to Meteorological Change: Hourly Analysis of Air Temperature in Changsha, China

Atmosphere
Enhancing greenspace cooling efficiency (GCE) is a cost-effective nature-based solution to improve the urban thermal environment. The spatiotemporal patterns of GCE and their driving factors have been investigated mainly based on land surface temperature
Yang Li, Weiye Wang, Xin Li, Wei Liao, Xiaoma Li   +4 more
doaj   +1 more source