Results 71 to 80 of about 305,128 (260)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
E3S Web of Conferences, 2018 Public participation plays a decisive role in the way to achieve sustainability deign for local redevelopment. Guangfu Village, the first garden city model town in Taiwan is facing redevelopment issue when executing sustainable design with human ...
Hsu Kuo-Wei, Chao Chieh-Yu
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Designer landscapes for sustainable biofuels
Trends in Ecology & Evolution, 2009 Oil palm is one of the most extensively cultivated biodiesel feedstocks worldwide, and expansion of its cultivation poses a significant threat to ecosystems, biodiversity and potentially the global climate. We evaluate the prospects of land sparing and wildlife-friendly farming, two contrasting approaches for reducing the impacts of oil palm ...
Koh, L.P., Levang, P., Ghazoul, J.
openaire +5 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Ekológia (Bratislava), 2015 Value tightening of acceptable soil loss by wind erosion in amendment to the Act No. 220/2004 on Protection and Use of Agricultural Land in the Slovak Republic from 1st of April 2013 is necessary to reconsider wind erosion intensity in agricultural ...
Streďanský Jozef +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Ri-vista: Ricerche per la Progettazione del PaesaggioThis study proposes a framework for analyzing the medina of Tunis, based on Richard T.T. Forman's theory of land mosaics. Departing from traditional preservationist methods, it views the Medina as a multifaceted landscape, integrating both tangible and ...
Gareth Doherty, Areti Kotsoni
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source