Results 71 to 80 of about 1,182,283 (252)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

[Review of] Paul M. Sniderman and Thomas Piazza. The Scar of Race [PDF]

, 1994
Into the murky, politically-charged waters of contemporary racial politics shines this welcome ray of light. Paul M. Sniderman and Thomas Piazza, using clever research design and innovative techniques, clarify the changing meaning of race in today’s ...
Goldstein-Shirley, David
core   +1 more source

Learning Design: reflections on a snapshot of the current landscape [PDF]

, 2012
The mounting wealth of open and readily available information and the swift evolution of social, mobile and creative technologies warrant a re-conceptualisation of the role of educators: from providers of knowledge to designers of learning.
Berggren A, Buck G. H, Koper R, Resnick M, Ronen-Fuhrmann T.   +4 more
core   +3 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

How Highway Landscape Visual Qualities Are Being Studied: A Systematic Literature Review

Land
Highways play a vital role in the road transport system, connecting regions and cities in many parts of the world. It may sometimes offer scenic views or a visually appealing environment based on the availability of unique compositions of natural and man-
Hangyu Gao, Shamsul Abu Bakar, Suhardi Maulan, Mohd Johari Mohd Yusof, Riyadh Mundher, Benxue Chen   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Study on the Spatiotemporal Patterns and Influencing Factors of Maize Planting in Hunan Province

Agronomy
Maize, one of the world’s three major food crops, plays a vital role in global food security. Analyzing the spatiotemporal patterns of maize cultivation in Hunan Province and their influencing factors contributes to enhancing planting quality and ...
Qinhao Xiao, Xigui Li, Jingyi Ma, Liangwei Zhu, Kequan Gong, Siting Zhan   +5 more
doaj   +1 more source

Examining the role of concrete 3D printing for housing construction on Indigenous Reserves in Canada [PDF]

Frontiers in Engineering and Built Environment
Purpose – This research explores the role of concrete 3D printing (C3DP) in the development of culturally appropriate housing in Indigenous Reserves in Canada through the design, building and evaluation of the Star Lodge project located in the Siksika ...
Mauricio Soto Rubio, Muhammad Fauzan Mirza, Mustafa Kagdi, Ahmad Ali Bisati   +3 more
doaj   +1 more source

Urban agriculture and sustainable urban landscape. An applied research on two case studies (Madagascar and Senegal) [PDF]

, 2010
In developing countries, like in Madagascar and Senegal facing high rates of urbanisation, urban agriculture is progressively taken into account in urban planning.
Aubry, Christine, Ba, Awa, Dabat, Marie-Hélène, Ramamonjisoa, Josélyne   +3 more
core   +4 more sources