Results 91 to 100 of about 1,182,283 (252)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Themes of drawing and digital context: student engagement with theory and practice using the tool of the integrated learning portfolio [PDF]
, 2012 This article presents a reflective visual narrative documenting the learning encounters of BA (Hons) Surface Design undergraduates using the Integrated Learning Portfolio (ILP) tool in Year one.
Bailey, Rowan +2 more
core
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Citizens contributing in landscape in the Netherlands [PDF]
With the continuing loss of landscape elements and open space, landscape management is gaining importance in tandem with the design of acceptable private and voluntary financing arrangements. Here, we analyze the awareness, involvement, socio-demographic
Graaff, R.P.M., de +2 more
core +1 more source
Waiheke Island : perceptions of the environment : a thesis presented in partial fulfilment of the requirements for the degree of Master of Management at Massey University at Albany, New Zealand [PDF]
, 2002 The need for the sustainable management of resources has been recognised since the early 1980s. However, the concept that the physical landscape is also a resource which needs to be managed and quantified is more recent.
Histen, Suzanne Teresa
core
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Ekológia (Bratislava), 2015 Value tightening of acceptable soil loss by wind erosion in amendment to the Act No. 220/2004 on Protection and Use of Agricultural Land in the Slovak Republic from 1st of April 2013 is necessary to reconsider wind erosion intensity in agricultural ...
Streďanský Jozef +3 more
doaj +1 more source
A Detailed Analysis of Contemporary ARM and x86 Architectures [PDF]
, 2013 RISC vs. CISC wars raged in the 1980s when chip area and processor design complexity were the primary constraints and desktops and servers exclusively dominated the computing landscape.
Blem, Emily +2 more
core +2 more sources