Results 41 to 50 of about 952,563 (300)

Attractor Metadynamics in Adapting Neural Networks

, 2014
Slow adaption processes, like synaptic and intrinsic plasticity, abound in the brain and shape the landscape for the neural dynamics occurring on substantially faster timescales.
C. Gros, C. Gros, C. Gros, C.J. Honey, D. Marković, E. Marder, E. Russo, E.T. Jaynes, G. Daoudal, G. Deco, G.G. Turrigiano, J. Triesch, J.J. Hopfield, J.J. Steil, M. Linkerhand, N. Ulanovsky, R.D. Beer, R.D. Beer, R.D. Beer, T. O’Leary   +19 more
core   +1 more source

Simulation and analysis of in vitro DNA evolution [PDF]

, 2003
We study theoretically the in vitro evolution of a DNA sequence by binding to a transcription factor. Using a simple model of protein-DNA binding and available binding constants for the Mnt protein, we perform large-scale, realistic simulations of ...
Chao Tang, D. A. Kessler, G. D. Stormo, L. F. Landweber, M. T. Record, Jr., Morten Kloster, T.-K. Man   +6 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Recombination dramatically speeds up evolution of finite populations

, 2004
We study the role of recombination, as practiced by genetically-competent bacteria, in speeding up Darwinian evolution. This is done by adding a new process to a previously-studied Markov model of evolution on a smooth fitness landscape; this new process
A. S. Kondrashov, B. Charlesworth, D. A. Kessler, E. Baum, Hans-Georg Beyer, I. S. Novella, J. Felsenstein, N. H. Barton, R. Miralles, R. Redfield, S. P. Otto, S. P. Otto, W. R. Rice   +12 more
core   +1 more source

Quantitative Modeling of Landscape Evolution

, 2022
This chapter reviews quantitative modeling of landscape evolution. Quantitative modeling is contrasted with conceptual or physical modeling, and four categories of model studies are presented. Procedural studies focus on model experimentation. Descriptive studies use models to learn about landscapes in general.
Temme, Arnaud, Schoorl, J.M., Claessens, L.F.G., Veldkamp, A.   +3 more
openaire   +5 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Fitness Landscapes and Evolution [PDF]

, 1996
The concept of fitness is introduced, and a simple derivation of the Fundamental Theorem of Natural Selection (which states that the average fitness of a population increases if its variance is nonzero) is given. After a short discussion of the adaptative walk model, a short review is given of the quasispecies approach to molecular evolution and to the
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Modelling the role of groundwater hydro-refugia in East African hominin evolution and dispersal

Nature Communications, 2017
Water is a fundamental resource, but its role in hominin evolution is not well explored. Here, the authors use a combination of groundwater, climate and agent-based models to show that groundwater availability may be critical to past patterns of ...
M. O. Cuthbert, T. Gleeson, S. C. Reynolds, M. R. Bennett, A. C. Newton, C. J. McCormack, G. M. Ashley   +6 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source