Results 61 to 70 of about 3,704,485 (249)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Three‐Dimensional Modeling of the Coevolution of Landscape and Soil Organic Carbon

Water Resources Research, 2019
Soil organic carbon (SOC) is going through rapid reorganization due to anthropogenic influences. Understanding how biogeochemical transformation and erosion‐induced SOC redistribution influence SOC profiles and stocks is critical to our food security and
Qina Yan, Phong V. V. Le, Dong K. Woo, Tingyu Hou, Timothy Filley, Praveen Kumar   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Modeling postbreakup landscape development and denudational history across the southeast African (Drakensberg Escarpment) margin [PDF]

, 2002
We employ a numerical surface processes model to study the controls on postbreakup landscape development and denudational history of the southeast African margin.
Alastair Fleming, Braun, J., Brown, R. W., Fleming, A., van der Beek, P., Peter van der Beek, Roderick W. Brown, Michael A. Summerfield, Jean Braun, Summerfield, M. A.   +9 more
core   +1 more source

A Confidence Scoring Procedure for eDNA Metabarcoding Records and Its Application to a Global Marine Fish Dataset

Environmental DNA
Environmental DNA (eDNA) metabarcoding is changing the way biodiversity is surveyed in many types of ecosystems. eDNA surveys are now commonly performed and integrated into biodiversity monitoring programs and public databases.
Andrea Polanco F., Romane Rozanski, Virginie Marques, Martin Helmkampf, David Mouillot, Stéphanie Manel, Camille Albouy, Oscar Puebla, Loïc Pellissier   +8 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Science for action at the local landscape scale

, 2013
For landscape ecology to produce knowledge relevant to society, it must include considerations of human culture and behavior, extending beyond the natural sciences to synthesize with many other disciplines.
Liu, Jianguo, Albert, C., Nassauer, JI, Liu, J. G., Swaffield, Simon, Swaffield, SR, Opdam, Paul, McAlpine, C, Castella, J-C, Sheppard, S, Sheppard, Stephen, Nassauer, Joan Iverson, Nassauer, J. I., McAlpine, Clive, McAlpine, C., Bentrup, G, Wang, Z, Albert, C, Wang, Zhifang, Opdam, P, Opdam, P., Castella, Jean-Christophe, Swaffield, S., Liu, J, Bentrup, G., Albert, Christian, Wang, Z. F., Bentrup, Gary, Sheppard, S.   +28 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source