Results 81 to 90 of about 952,563 (300)

Three‐Dimensional Modeling of the Coevolution of Landscape and Soil Organic Carbon

Water Resources Research, 2019
Soil organic carbon (SOC) is going through rapid reorganization due to anthropogenic influences. Understanding how biogeochemical transformation and erosion‐induced SOC redistribution influence SOC profiles and stocks is critical to our food security and
Qina Yan, Phong V. V. Le, Dong K. Woo, Tingyu Hou, Timothy Filley, Praveen Kumar   +5 more
doaj   +1 more source

Effects of random pinning on the potential energy landscape of a supercooled liquid

, 2019
We use energy landscape methods to investigate the response of a supercooled liquid to random pinning. We classify the structural similarity of different energy minima using a measure of overlap.
de Souza, V. K., Jack, R. L., Niblett, S. P., Wales, D. J   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A Confidence Scoring Procedure for eDNA Metabarcoding Records and Its Application to a Global Marine Fish Dataset

Environmental DNA
Environmental DNA (eDNA) metabarcoding is changing the way biodiversity is surveyed in many types of ecosystems. eDNA surveys are now commonly performed and integrated into biodiversity monitoring programs and public databases.
Andrea Polanco F., Romane Rozanski, Virginie Marques, Martin Helmkampf, David Mouillot, Stéphanie Manel, Camille Albouy, Oscar Puebla, Loïc Pellissier   +8 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Cellular Models for River Networks

, 2000
A cellular model introduced for the evolution of the fluvial landscape is revisited using extensive numerical and scaling analyses. The basic network shapes and their recurrence especially in the aggregation structure are then addressed.
A. D. Howard, A. Maritan, A. Rinaldo, A. Rinaldo, A. Rinaldo, A. Rinaldo, A.D. Howard, B. B. Mandelbrot, D.G. Tarboton, D.R. Montgomery, D.R. Montgomery, G. Caldarelli, G.R. Willgoose, Guido Caldarelli, I. Rodriguez-Iturbe, I. Rodriguez-Iturbe, I. Rodriguez-Iturbe, I. Rodriguez-Iturbe, J. Feder, J.T. Hack, K. Sinclair, L. Band, M. Marani, P. Bak, P. La Barbera, R. Rigon, R. Rigon, V. Sapozhnikov, W.E. Dietrich   +28 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

THE CONDITIONING FEATURES OF DITCHES PROCESSES AT THE SEDIMENTARY STRUCTURES OF THE PERIPHERAL DEPRESSION IN RIO GRANDE DO SUL [PDF]

Sociedade & Natureza, 2005
Aiming to define the conditioning features responsible for the different erosionprocesses actuating at the drain heads between Jacuí and Ibicuí rivers - at PeripheralDepression in Rio Grande do Sul, we analysed the geologic/geomorphologic aspects ...
Ivaniza de Lourdes Lazzarotto Cabral, Jurandyr Luciano Sanches Ross, Luis Eduardo Robaina, Edgardo Medeiros   +3 more
doaj  

Adaptation in tunably rugged fitness landscapes: The Rough Mount Fuji Model

, 2014
Much of the current theory of adaptation is based on Gillespie's mutational landscape model (MLM), which assumes that the fitness values of genotypes linked by single mutational steps are independent random variables. On the other hand, a growing body of
Krug, Joachim, Neidhart, Johannes, Szendro, Ivan G.   +2 more
core   +1 more source

The evolution of landscapes [PDF]

Nature, 1982
Climatic Geomorphology. By Julius Budel. Pp.528. Hbk ISBN 0-691-08294-4; pbk ISBN 0-691-08295-2. (Princeton University Press: 1982.) Hbk £40.62, $65; pbk £15.31, $24.50.
openaire   +1 more source