Results 81 to 90 of about 3,704,485 (249)

Modelling the geomorphic history of the Tribeč Mts. and the Pohronský Inovec Mts. (Western Carpathians) with the CHILD model

Open Geosciences, 2016
Numerical models were developed in order to provide a suitable computational framework for exploring research questions related to long-term landscape evolution.
Staškovanová Veronika, Minár Jozef
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Birds of Berlin: Changes in communities and guilds in the urban park “Tiergarten” since 1850

Ecology and Evolution
Urbanization has far‐reaching consequences on birds, and knowledge of the impacts on taxonomic and functional diversity is necessary to make cities as compatible as possible for species.
Esther Sophie Felgentreff, Nadja Pernat, Sascha Buchholz   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Geoarchaeology and PalaeoDEMs Modelling to Assess the Archaeological Potential of Ravenna and Its Hinterland

Journal of Open Archaeology Data
This paper presents a collection of nine datasets developed as part of a PhD research project in Archaeology to investigate landscape transformations in the hinterland of Ravenna.
Michele Abballe
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Landscape science: a Russian geographical tradition [PDF]

, 2007
The Russian geographical tradition of landscape science (landshaftovedenie) is analyzed with particular reference to its initiator, Lev Semenovich Berg (1876-1950). The differences between prevailing Russian and Western concepts of landscape in geography
Oldfield, Jonathan; id_orcid, Oldfield, J., Shaw, Denis, Shaw, D.J.B.   +3 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Continuity in morphological disparity in tropical reef fishes across evolutionary scales

Communications Biology
Tropical reef fishes exhibit a large disparity of organismal morphologies contributing to their astonishing biodiversity. Morphological disparity, scaling from differences among individuals within populations to differences among species, is governed by ...
Giulia Francesca Azzurra Donati, Camille Albouy, Thomas Claverie, David Mouillot, Rodney Govinden, Oskar Hagen, Shameel Ibrahim, Julius Pagu, Irthisham Zareer, Fabien Leprieur, Loïc Pellissier   +10 more
doaj   +1 more source

The ground beneath our feet: A critical reflection on 135 years of landscape evolution models for southern Africa

South African Journal of Science
In his 1925 paper describing the Taung Child fossil, Dart makes various assertions about the landscape around Taung, inferring past climate dynamics, and the role these factors play in the evolution of our early prehuman relatives.
Rivoningo Khosa, Vela Mbele, Kelly Kirsten, Robyn Pickering   +3 more
doaj   +1 more source