Results 101 to 110 of about 3,704,485 (249)

Landscape Evolution and It's Impact of Ecosystem Service Value of the Wuhan City, China. [PDF]

Int J Environ Res Public Health, 2021
Chen R, Huang C.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Climate‐Driven Topographic Asymmetry Enhanced by Glaciers: Implications for Drainage Reorganization in Glacial Landscapes

Geophysical Research Letters
Climate contrasts across drainage divides, such as orographic precipitation, are ubiquitous in mountain ranges, and as a result, mountain topography is often asymmetric.
Jingtao Lai, Kimberly Huppert
doaj   +1 more source

Dating the landscape evolution around the Chauvet-Pont d'Arc cave. [PDF]

Sci Rep, 2021
Genuite K, Delannoy JJ, Bahain JJ, Gresse M, Jaillet S, Philippe A, Pons-Branchu E, Revil A, Voinchet P.   +8 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Landscape ecology integrates pattern and process in river corridors

, 1999
Landscape ecology holds the potential for developing a truly holistic perspective of river corridors, one that rigorously integrates structure, dynamics, and function.
Tockner, K. (author), Ward, J.V. (author), Malard, F. (author)   +2 more
core   +1 more source

Multi‐Century Erosion and Landscape Evolution of Ephemeral Catchments in Response to Sub‐Daily Rainfall Distribution Changes

Geophysical Research Letters
Changes in the properties of rainfall distributions at sub‐daily scales are key to assessing soil erosion rates under climate transition. However, such changes are difficult to detect and model, especially over landscape evolution timescales.
Yuval Shmilovitz, Matthew W. Rossi, Gregory E. Tucker   +2 more
doaj   +1 more source

Holocene landscape evolution and its interaction with human activities in the southern piedmont of Taihang Mountain, Central China. [PDF]

Front Plant Sci, 2022
Zhang X, Yang S, Lu P, Li Y, Chen P, Xia Z.   +5 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The Lasting Legacy of Megaflood Boulder Deposition in Mountain Rivers

Geophysical Research Letters
Infrequent, large‐magnitude discharge (>106 m3/s) outburst floods—megafloods—can play a major role in landscape evolution. Prehistoric glacial lake outburst megafloods transported and deposited large boulders (≥4 m), yet few studies consider their ...
S. M. Morey, C. M. Shobe, K. W. Huntington, K. A. Lang, A. G. Johnson, A. R. Duvall   +5 more
doaj   +1 more source