Results 111 to 120 of about 188,104 (310)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Industrial landscape Evolution in the Devil's Valley [PDF]
The evolution of the specific characteristics of the landscape in the context under investigation, is as in other areas, strongly influenced by industrial development. In the Devil’s Valley, located in the upper Val di Cecina, with the activation of
Lorenzo Ceccarelli, Roberto Castiglia
core
The role of landscape structure in determining eco-evolutionary dynamics during environmental change [PDF]
, 2008 Climate change may produce a variety of responses in populations' ecological and evolutionary dynamics. At opposing limits of populations' ranges, the responses are expected to differ.
McInerny, Gregory John
core
Journal of Open Archaeology DataThis paper presents a collection of nine datasets developed as part of a PhD research project in Archaeology to investigate landscape transformations in the hinterland of Ravenna.
Michele Abballe
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Landscape change and its effects on the visual experience of a case study area in the Öresunds region [PDF]
The study focuses on landscape change, from an historical perspective (year 1915) and as a discussion of future changes (year 2015) for a case study area in southern Sweden.
Åsa Ode
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Continuity in morphological disparity in tropical reef fishes across evolutionary scales
Communications BiologyTropical reef fishes exhibit a large disparity of organismal morphologies contributing to their astonishing biodiversity. Morphological disparity, scaling from differences among individuals within populations to differences among species, is governed by ...
Giulia Francesca Azzurra Donati +10 more
doaj +1 more source
Isolating climatic, tectonic, and lithologic controls on mountain landscape evolution. [PDF]
Sci Adv, 2023 Leonard JS, Whipple KX, Heimsath AM.
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source